Prenatal dexamethasone exposure does not alter blood pressure and nephron number in the young adult marmoset monkey
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Prenatal dexamethasone exposure does not alter blood pressure and nephron number in the young adult marmoset monkey. / Bramlage, Carsten Paul; Schlumbohm, Christina; Pryce, Christopher Robert; Mirza, Serkan; Schnell, Christian; Amann, Kerstin; Amstrong, Victor William; Eitner, Frank; Zapf, Antonia; Feldon, Joram; Oellerich, Michael; Fuchs, Eberhard; Müller, Gerhard Anton; Strutz, Frank.
in: HYPERTENSION, Jahrgang 54, Nr. 5, 11.2009, S. 1115-22.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Prenatal dexamethasone exposure does not alter blood pressure and nephron number in the young adult marmoset monkey
AU - Bramlage, Carsten Paul
AU - Schlumbohm, Christina
AU - Pryce, Christopher Robert
AU - Mirza, Serkan
AU - Schnell, Christian
AU - Amann, Kerstin
AU - Amstrong, Victor William
AU - Eitner, Frank
AU - Zapf, Antonia
AU - Feldon, Joram
AU - Oellerich, Michael
AU - Fuchs, Eberhard
AU - Müller, Gerhard Anton
AU - Strutz, Frank
PY - 2009/11
Y1 - 2009/11
N2 - The influence of prenatal factors on the development of arterial hypertension has gained considerable interest in recent years. Prenatal dexamethasone exposure was found to induce hypertension and to alter nephron number and size in rodents and sheep. However, it is not clear whether these findings are applicable to nonhuman primates. Thus, we examined the effects of prenatal dexamethasone treatment on blood pressure (BP) and nephron number in marmoset monkeys. Fifty-two marmosets were allotted to 3 groups according to the gestational stage during which their mothers were exposed to oral 5-mg/kg dexamethasone for 7 days (gestation period: 20 weeks): (1) the early dexamethasone group at week 7; (2) the late dexamethasone group at week 13; and (3) the control group. BP was determined by telemetric (n=12) or cuff measurements (n=30), along with cystatin C, proteinuria, and body weight. All of the animals were euthanized at the age of 24 months, and glomerular number and volume were determined. Prenatal exposure to dexamethasone did not lead to a significant difference between the groups with regard to BP, kidney morphology and function, or body weight. BP correlated significantly with body weight, relative kidney weight, and mean glomerular volume and the body weight with the glomerular volume regardless of dexamethasone treatment. In conclusion, prenatal exposure to dexamethasone in marmosets does not, in contrast to other mammals studied, result in hypertension or changes in kidney morphology. Our data support the role of body weight as a predictor of elevated glomerular volume and BP development rather than prenatal dexamethasone exposure.
AB - The influence of prenatal factors on the development of arterial hypertension has gained considerable interest in recent years. Prenatal dexamethasone exposure was found to induce hypertension and to alter nephron number and size in rodents and sheep. However, it is not clear whether these findings are applicable to nonhuman primates. Thus, we examined the effects of prenatal dexamethasone treatment on blood pressure (BP) and nephron number in marmoset monkeys. Fifty-two marmosets were allotted to 3 groups according to the gestational stage during which their mothers were exposed to oral 5-mg/kg dexamethasone for 7 days (gestation period: 20 weeks): (1) the early dexamethasone group at week 7; (2) the late dexamethasone group at week 13; and (3) the control group. BP was determined by telemetric (n=12) or cuff measurements (n=30), along with cystatin C, proteinuria, and body weight. All of the animals were euthanized at the age of 24 months, and glomerular number and volume were determined. Prenatal exposure to dexamethasone did not lead to a significant difference between the groups with regard to BP, kidney morphology and function, or body weight. BP correlated significantly with body weight, relative kidney weight, and mean glomerular volume and the body weight with the glomerular volume regardless of dexamethasone treatment. In conclusion, prenatal exposure to dexamethasone in marmosets does not, in contrast to other mammals studied, result in hypertension or changes in kidney morphology. Our data support the role of body weight as a predictor of elevated glomerular volume and BP development rather than prenatal dexamethasone exposure.
KW - Analysis of Variance
KW - Animals
KW - Blood Pressure
KW - Blood Pressure Determination
KW - Callithrix
KW - Cystatin C
KW - Dexamethasone
KW - Female
KW - Haplorhini
KW - Kidney Glomerulus
KW - Male
KW - Nephrons
KW - Organ Size
KW - Pregnancy
KW - Pregnancy, Animal
KW - Prenatal Exposure Delayed Effects
KW - Probability
KW - Proteinuria
KW - Reference Values
KW - Comparative Study
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1161/HYPERTENSIONAHA.109.136580
DO - 10.1161/HYPERTENSIONAHA.109.136580
M3 - SCORING: Journal article
C2 - 19770406
VL - 54
SP - 1115
EP - 1122
JO - HYPERTENSION
JF - HYPERTENSION
SN - 0194-911X
IS - 5
ER -
