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Preliminary evidence that ketamine inhibits spreading depolarizations in acute human brain injury

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Preliminary evidence that ketamine inhibits spreading depolarizations in acute human brain injury. / Sakowitz, Oliver W; Kiening, Karl L; Krajewski, Kara L; Sarrafzadeh, Asita S; Fabricius, Martin; Strong, Anthony J; Unterberg, Andreas W; Dreier, Jens P.

in: STROKE, Jahrgang 40, Nr. 8, 08.2009, S. e519-22.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Sakowitz, OW, Kiening, KL, Krajewski, KL, Sarrafzadeh, AS, Fabricius, M, Strong, AJ, Unterberg, AW & Dreier, JP 2009, 'Preliminary evidence that ketamine inhibits spreading depolarizations in acute human brain injury', STROKE, Jg. 40, Nr. 8, S. e519-22. https://doi.org/10.1161/STROKEAHA.109.549303

APA

Sakowitz, O. W., Kiening, K. L., Krajewski, K. L., Sarrafzadeh, A. S., Fabricius, M., Strong, A. J., Unterberg, A. W., & Dreier, J. P. (2009). Preliminary evidence that ketamine inhibits spreading depolarizations in acute human brain injury. STROKE, 40(8), e519-22. https://doi.org/10.1161/STROKEAHA.109.549303

Vancouver

Sakowitz OW, Kiening KL, Krajewski KL, Sarrafzadeh AS, Fabricius M, Strong AJ et al. Preliminary evidence that ketamine inhibits spreading depolarizations in acute human brain injury. STROKE. 2009 Aug;40(8):e519-22. https://doi.org/10.1161/STROKEAHA.109.549303

Bibtex

@article{ee0f7051c2c848d2b30ab041cb30c617,
title = "Preliminary evidence that ketamine inhibits spreading depolarizations in acute human brain injury",
abstract = "BACKGROUND AND PURPOSE: Spreading depolarizations, characterized by large propagating, slow potential changes, have been demonstrated with electrocorticography in patients with cerebral hemorrhage and ischemic stroke. Whereas spreading depolarizations are harmless under normal conditions in animals, they cause or augment damage in the ischemic brain. A fraction of spreading depolarizations is abolished by N-methyl-d-aspartate receptor antagonists. Summary of Case- In 2 patients with severe acute brain injury (traumatic and spontaneous intracranial hemorrhage), spreading depolarizations were inhibited by the noncompetitive N-methyl-d-aspartate receptor antagonist ketamine. This restored electrocorticographic activity.CONCLUSIONS: These anecdotal electrocorticographic findings suggest that ketamine has an inhibitory effect on spreading depolarizations in humans. This is of potential interest for future neuroprotective trials.",
keywords = "Adult, Brain Injuries, Cortical Spreading Depression, Humans, Ketamine, Male, Middle Aged",
author = "Sakowitz, {Oliver W} and Kiening, {Karl L} and Krajewski, {Kara L} and Sarrafzadeh, {Asita S} and Martin Fabricius and Strong, {Anthony J} and Unterberg, {Andreas W} and Dreier, {Jens P}",
year = "2009",
month = aug,
doi = "10.1161/STROKEAHA.109.549303",
language = "English",
volume = "40",
pages = "e519--22",
journal = "STROKE",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

RIS

TY - JOUR

T1 - Preliminary evidence that ketamine inhibits spreading depolarizations in acute human brain injury

AU - Sakowitz, Oliver W

AU - Kiening, Karl L

AU - Krajewski, Kara L

AU - Sarrafzadeh, Asita S

AU - Fabricius, Martin

AU - Strong, Anthony J

AU - Unterberg, Andreas W

AU - Dreier, Jens P

PY - 2009/8

Y1 - 2009/8

N2 - BACKGROUND AND PURPOSE: Spreading depolarizations, characterized by large propagating, slow potential changes, have been demonstrated with electrocorticography in patients with cerebral hemorrhage and ischemic stroke. Whereas spreading depolarizations are harmless under normal conditions in animals, they cause or augment damage in the ischemic brain. A fraction of spreading depolarizations is abolished by N-methyl-d-aspartate receptor antagonists. Summary of Case- In 2 patients with severe acute brain injury (traumatic and spontaneous intracranial hemorrhage), spreading depolarizations were inhibited by the noncompetitive N-methyl-d-aspartate receptor antagonist ketamine. This restored electrocorticographic activity.CONCLUSIONS: These anecdotal electrocorticographic findings suggest that ketamine has an inhibitory effect on spreading depolarizations in humans. This is of potential interest for future neuroprotective trials.

AB - BACKGROUND AND PURPOSE: Spreading depolarizations, characterized by large propagating, slow potential changes, have been demonstrated with electrocorticography in patients with cerebral hemorrhage and ischemic stroke. Whereas spreading depolarizations are harmless under normal conditions in animals, they cause or augment damage in the ischemic brain. A fraction of spreading depolarizations is abolished by N-methyl-d-aspartate receptor antagonists. Summary of Case- In 2 patients with severe acute brain injury (traumatic and spontaneous intracranial hemorrhage), spreading depolarizations were inhibited by the noncompetitive N-methyl-d-aspartate receptor antagonist ketamine. This restored electrocorticographic activity.CONCLUSIONS: These anecdotal electrocorticographic findings suggest that ketamine has an inhibitory effect on spreading depolarizations in humans. This is of potential interest for future neuroprotective trials.

KW - Adult

KW - Brain Injuries

KW - Cortical Spreading Depression

KW - Humans

KW - Ketamine

KW - Male

KW - Middle Aged

U2 - 10.1161/STROKEAHA.109.549303

DO - 10.1161/STROKEAHA.109.549303

M3 - SCORING: Journal article

C2 - 19520992

VL - 40

SP - e519-22

JO - STROKE

JF - STROKE

SN - 0039-2499

IS - 8

ER -