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Prehabilitation in older patients prior to elective cardiac procedures (PRECOVERY): study protocol of a multicenter randomized controlled trial

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Prehabilitation in older patients prior to elective cardiac procedures (PRECOVERY): study protocol of a multicenter randomized controlled trial. / Steinmetz, Carolin; Heinemann, Stephanie; Kutschka, Ingo; Hasenfuß, Gerd; Asendorf, Thomas; Remppis, Bjoern Andrew; Knoglinger, Ernst; Grefe, Clemens; Albes, Johannes Maximilian; Baraki, Hassina; Baumbach, Christian; Brunner, Susanne; Ernst, Susann; Harringer, Wolfgang; Heider, Dirk; Heidkamp, Daniela; Herrmann-Lingen, Christoph; Hummers, Eva; Kocar, Thomas; König, Hans-Helmut; Krieger, Simone; Liebold, Andreas; Martens, Andreas; Matzeder, Marcus; Mellert, Friedrich; Müller, Christiane; Puls, Miriam; Reiss, Nils; Schikora, Martin; Schmidt, Thomas; Vestweber, Martin; Sadlonova, Monika; von Arnim, Christine A F; PRECOVERY investigators.

in: TRIALS, Jahrgang 24, 15.08.2023, S. 533.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Steinmetz, C, Heinemann, S, Kutschka, I, Hasenfuß, G, Asendorf, T, Remppis, BA, Knoglinger, E, Grefe, C, Albes, JM, Baraki, H, Baumbach, C, Brunner, S, Ernst, S, Harringer, W, Heider, D, Heidkamp, D, Herrmann-Lingen, C, Hummers, E, Kocar, T, König, H-H, Krieger, S, Liebold, A, Martens, A, Matzeder, M, Mellert, F, Müller, C, Puls, M, Reiss, N, Schikora, M, Schmidt, T, Vestweber, M, Sadlonova, M, von Arnim, CAF & PRECOVERY investigators 2023, 'Prehabilitation in older patients prior to elective cardiac procedures (PRECOVERY): study protocol of a multicenter randomized controlled trial', TRIALS, Jg. 24, S. 533. https://doi.org/10.1186/s13063-023-07511-w

APA

Steinmetz, C., Heinemann, S., Kutschka, I., Hasenfuß, G., Asendorf, T., Remppis, B. A., Knoglinger, E., Grefe, C., Albes, J. M., Baraki, H., Baumbach, C., Brunner, S., Ernst, S., Harringer, W., Heider, D., Heidkamp, D., Herrmann-Lingen, C., Hummers, E., Kocar, T., ... PRECOVERY investigators (2023). Prehabilitation in older patients prior to elective cardiac procedures (PRECOVERY): study protocol of a multicenter randomized controlled trial. TRIALS, 24, 533. https://doi.org/10.1186/s13063-023-07511-w

Vancouver

Steinmetz C, Heinemann S, Kutschka I, Hasenfuß G, Asendorf T, Remppis BA et al. Prehabilitation in older patients prior to elective cardiac procedures (PRECOVERY): study protocol of a multicenter randomized controlled trial. TRIALS. 2023 Aug 15;24:533. https://doi.org/10.1186/s13063-023-07511-w

Bibtex

@article{4fcea15184214f848587243366e68808,
title = "Prehabilitation in older patients prior to elective cardiac procedures (PRECOVERY): study protocol of a multicenter randomized controlled trial",
abstract = "BACKGROUND: Previous studies have demonstrated the efficacy of rehabilitation after a cardiovascular procedure. Especially older and multimorbid patients benefit from rehabilitation after a cardiac procedure. Prehabilitation prior to cardiac procedures may also have positive effects on patients' pre- and postoperative outcomes. Results of a current meta-analysis show that prehabilitation prior to cardiac procedures can improve perioperative outcomes and alleviate adverse effects. Germany currently lacks a structured cardiac prehabilitation program for older patients, which is coordinated across healthcare sectors.METHODS: In a randomized, controlled, two-arm parallel group, assessor-blinded multicenter intervention trial (PRECOVERY), we will randomize 422 patients aged 75 years or older scheduled for an elective cardiac procedure (e.g., coronary artery bypass graft surgery or transcatheter aortic valve replacement). In PRECOVERY, patients randomized to the intervention group participate in a 2-week multimodal prehabilitation intervention conducted in selected cardiac-specific rehabilitation facilities. The multimodal prehabilitation includes seven modules: exercise therapy, occupational therapy, cognitive training, psychosocial intervention, disease-specific education, education with relatives, and nutritional intervention. Participants in the control group receive standard medical care. The co-primary outcomes are quality of life (QoL) and mortality after 12 months. QoL will be measured by the EuroQol 5-dimensional questionnaire (EQ-5D-5L). A health economic evaluation using health insurance data will measure cost-effectiveness. A mixed-methods process evaluation will accompany the randomized, controlled trial to evaluate dose, reach, fidelity and adaptions of the intervention.DISCUSSION: In this study, we investigate whether a tailored prehabilitation program can improve long-term survival, QoL and functional capacity. Additionally, we will analyze whether the intervention is cost-effective. This is the largest cardiac prehabilitation trial targeting the wide implementation of a new form of care for geriatric cardiac patients.TRIAL REGISTRATION: German Clinical Trials Register (DRKS; http://www.drks.de ; DRKS00030526). Registered on 30 January 2023.",
author = "Carolin Steinmetz and Stephanie Heinemann and Ingo Kutschka and Gerd Hasenfu{\ss} and Thomas Asendorf and Remppis, {Bjoern Andrew} and Ernst Knoglinger and Clemens Grefe and Albes, {Johannes Maximilian} and Hassina Baraki and Christian Baumbach and Susanne Brunner and Susann Ernst and Wolfgang Harringer and Dirk Heider and Daniela Heidkamp and Christoph Herrmann-Lingen and Eva Hummers and Thomas Kocar and Hans-Helmut K{\"o}nig and Simone Krieger and Andreas Liebold and Andreas Martens and Marcus Matzeder and Friedrich Mellert and Christiane M{\"u}ller and Miriam Puls and Nils Reiss and Martin Schikora and Thomas Schmidt and Martin Vestweber and Monika Sadlonova and {von Arnim}, {Christine A F} and {PRECOVERY investigators}",
note = "{\textcopyright} 2023. BioMed Central Ltd., part of Springer Nature.",
year = "2023",
month = aug,
day = "15",
doi = "10.1186/s13063-023-07511-w",
language = "English",
volume = "24",
pages = "533",
journal = "TRIALS",
issn = "1745-6215",
publisher = "Current Controlled Trials Ltd.",

}

RIS

TY - JOUR

T1 - Prehabilitation in older patients prior to elective cardiac procedures (PRECOVERY): study protocol of a multicenter randomized controlled trial

AU - Steinmetz, Carolin

AU - Heinemann, Stephanie

AU - Kutschka, Ingo

AU - Hasenfuß, Gerd

AU - Asendorf, Thomas

AU - Remppis, Bjoern Andrew

AU - Knoglinger, Ernst

AU - Grefe, Clemens

AU - Albes, Johannes Maximilian

AU - Baraki, Hassina

AU - Baumbach, Christian

AU - Brunner, Susanne

AU - Ernst, Susann

AU - Harringer, Wolfgang

AU - Heider, Dirk

AU - Heidkamp, Daniela

AU - Herrmann-Lingen, Christoph

AU - Hummers, Eva

AU - Kocar, Thomas

AU - König, Hans-Helmut

AU - Krieger, Simone

AU - Liebold, Andreas

AU - Martens, Andreas

AU - Matzeder, Marcus

AU - Mellert, Friedrich

AU - Müller, Christiane

AU - Puls, Miriam

AU - Reiss, Nils

AU - Schikora, Martin

AU - Schmidt, Thomas

AU - Vestweber, Martin

AU - Sadlonova, Monika

AU - von Arnim, Christine A F

AU - PRECOVERY investigators

N1 - © 2023. BioMed Central Ltd., part of Springer Nature.

PY - 2023/8/15

Y1 - 2023/8/15

N2 - BACKGROUND: Previous studies have demonstrated the efficacy of rehabilitation after a cardiovascular procedure. Especially older and multimorbid patients benefit from rehabilitation after a cardiac procedure. Prehabilitation prior to cardiac procedures may also have positive effects on patients' pre- and postoperative outcomes. Results of a current meta-analysis show that prehabilitation prior to cardiac procedures can improve perioperative outcomes and alleviate adverse effects. Germany currently lacks a structured cardiac prehabilitation program for older patients, which is coordinated across healthcare sectors.METHODS: In a randomized, controlled, two-arm parallel group, assessor-blinded multicenter intervention trial (PRECOVERY), we will randomize 422 patients aged 75 years or older scheduled for an elective cardiac procedure (e.g., coronary artery bypass graft surgery or transcatheter aortic valve replacement). In PRECOVERY, patients randomized to the intervention group participate in a 2-week multimodal prehabilitation intervention conducted in selected cardiac-specific rehabilitation facilities. The multimodal prehabilitation includes seven modules: exercise therapy, occupational therapy, cognitive training, psychosocial intervention, disease-specific education, education with relatives, and nutritional intervention. Participants in the control group receive standard medical care. The co-primary outcomes are quality of life (QoL) and mortality after 12 months. QoL will be measured by the EuroQol 5-dimensional questionnaire (EQ-5D-5L). A health economic evaluation using health insurance data will measure cost-effectiveness. A mixed-methods process evaluation will accompany the randomized, controlled trial to evaluate dose, reach, fidelity and adaptions of the intervention.DISCUSSION: In this study, we investigate whether a tailored prehabilitation program can improve long-term survival, QoL and functional capacity. Additionally, we will analyze whether the intervention is cost-effective. This is the largest cardiac prehabilitation trial targeting the wide implementation of a new form of care for geriatric cardiac patients.TRIAL REGISTRATION: German Clinical Trials Register (DRKS; http://www.drks.de ; DRKS00030526). Registered on 30 January 2023.

AB - BACKGROUND: Previous studies have demonstrated the efficacy of rehabilitation after a cardiovascular procedure. Especially older and multimorbid patients benefit from rehabilitation after a cardiac procedure. Prehabilitation prior to cardiac procedures may also have positive effects on patients' pre- and postoperative outcomes. Results of a current meta-analysis show that prehabilitation prior to cardiac procedures can improve perioperative outcomes and alleviate adverse effects. Germany currently lacks a structured cardiac prehabilitation program for older patients, which is coordinated across healthcare sectors.METHODS: In a randomized, controlled, two-arm parallel group, assessor-blinded multicenter intervention trial (PRECOVERY), we will randomize 422 patients aged 75 years or older scheduled for an elective cardiac procedure (e.g., coronary artery bypass graft surgery or transcatheter aortic valve replacement). In PRECOVERY, patients randomized to the intervention group participate in a 2-week multimodal prehabilitation intervention conducted in selected cardiac-specific rehabilitation facilities. The multimodal prehabilitation includes seven modules: exercise therapy, occupational therapy, cognitive training, psychosocial intervention, disease-specific education, education with relatives, and nutritional intervention. Participants in the control group receive standard medical care. The co-primary outcomes are quality of life (QoL) and mortality after 12 months. QoL will be measured by the EuroQol 5-dimensional questionnaire (EQ-5D-5L). A health economic evaluation using health insurance data will measure cost-effectiveness. A mixed-methods process evaluation will accompany the randomized, controlled trial to evaluate dose, reach, fidelity and adaptions of the intervention.DISCUSSION: In this study, we investigate whether a tailored prehabilitation program can improve long-term survival, QoL and functional capacity. Additionally, we will analyze whether the intervention is cost-effective. This is the largest cardiac prehabilitation trial targeting the wide implementation of a new form of care for geriatric cardiac patients.TRIAL REGISTRATION: German Clinical Trials Register (DRKS; http://www.drks.de ; DRKS00030526). Registered on 30 January 2023.

U2 - 10.1186/s13063-023-07511-w

DO - 10.1186/s13063-023-07511-w

M3 - SCORING: Journal article

C2 - 37582774

VL - 24

SP - 533

JO - TRIALS

JF - TRIALS

SN - 1745-6215

ER -