Prefrontal transcranial direct current stimulation changes connectivity of resting-state networks during fMRI.
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Prefrontal transcranial direct current stimulation changes connectivity of resting-state networks during fMRI. / Keeser, Daniel; Meindl, Thomas; Bor, Julie; Palm, Ulrich; Pogarell, Oliver; Mulert, Christoph; Brunelin, Jerome; Möller, Hans-Jürgen; Reiser, Maximilian; Padberg, Frank.
in: J NEUROSCI, Jahrgang 31, Nr. 43, 43, 2011, S. 15284-15293.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Prefrontal transcranial direct current stimulation changes connectivity of resting-state networks during fMRI.
AU - Keeser, Daniel
AU - Meindl, Thomas
AU - Bor, Julie
AU - Palm, Ulrich
AU - Pogarell, Oliver
AU - Mulert, Christoph
AU - Brunelin, Jerome
AU - Möller, Hans-Jürgen
AU - Reiser, Maximilian
AU - Padberg, Frank
PY - 2011
Y1 - 2011
N2 - Transcranial direct current stimulation (tDCS) has been proposed for experimental and therapeutic modulation of regional brain function. Specifically, anodal tDCS of the dorsolateral prefrontal cortex (DLPFC) together with cathodal tDCS of the supraorbital region have been associated with improvement of cognition and mood, and have been suggested for the treatment of several neurological and psychiatric disorders. Although modeled mathematically, the distribution, direction, and extent of tDCS-mediated effects on brain physiology are not well understood. The current study investigates whether tDCS of the human prefrontal cortex modulates resting-state network (RSN) connectivity measured by functional magnetic resonance imaging (fMRI). Thirteen healthy subjects underwent real and sham tDCS in random order on separate days. tDCS was applied for 20 min at 2 mA with the anode positioned over the left DLPFC and the cathode over the right supraorbital region. Patterns of resting-state brain connectivity were assessed before and after tDCS with 3 T fMRI, and changes were analyzed for relevant networks related to the stimulation-electrode localizations. At baseline, four RSNs were detected, corresponding to the default mode network (DMN), the left and right frontal-parietal networks (FPNs) and the self-referential network. After real tDCS and compared with sham tDCS, significant changes of regional brain connectivity were found for the DMN and the FPNs both close to the primary stimulation site and in connected brain regions. These findings show that prefrontal tDCS modulates resting-state functional connectivity in distinct functional networks of the human brain.
AB - Transcranial direct current stimulation (tDCS) has been proposed for experimental and therapeutic modulation of regional brain function. Specifically, anodal tDCS of the dorsolateral prefrontal cortex (DLPFC) together with cathodal tDCS of the supraorbital region have been associated with improvement of cognition and mood, and have been suggested for the treatment of several neurological and psychiatric disorders. Although modeled mathematically, the distribution, direction, and extent of tDCS-mediated effects on brain physiology are not well understood. The current study investigates whether tDCS of the human prefrontal cortex modulates resting-state network (RSN) connectivity measured by functional magnetic resonance imaging (fMRI). Thirteen healthy subjects underwent real and sham tDCS in random order on separate days. tDCS was applied for 20 min at 2 mA with the anode positioned over the left DLPFC and the cathode over the right supraorbital region. Patterns of resting-state brain connectivity were assessed before and after tDCS with 3 T fMRI, and changes were analyzed for relevant networks related to the stimulation-electrode localizations. At baseline, four RSNs were detected, corresponding to the default mode network (DMN), the left and right frontal-parietal networks (FPNs) and the self-referential network. After real tDCS and compared with sham tDCS, significant changes of regional brain connectivity were found for the DMN and the FPNs both close to the primary stimulation site and in connected brain regions. These findings show that prefrontal tDCS modulates resting-state functional connectivity in distinct functional networks of the human brain.
KW - Adult
KW - Humans
KW - Male
KW - Young Adult
KW - Double-Blind Method
KW - Magnetic Resonance Imaging
KW - Image Processing, Computer-Assisted
KW - Reaction Time
KW - Brain Mapping
KW - Neural Pathways/blood supply
KW - Oxygen/blood
KW - Prefrontal Cortex/blood supply/physiology
KW - Principal Component Analysis
KW - Rest/physiology
KW - Transcranial Magnetic Stimulation
KW - Adult
KW - Humans
KW - Male
KW - Young Adult
KW - Double-Blind Method
KW - Magnetic Resonance Imaging
KW - Image Processing, Computer-Assisted
KW - Reaction Time
KW - Brain Mapping
KW - Neural Pathways/blood supply
KW - Oxygen/blood
KW - Prefrontal Cortex/blood supply/physiology
KW - Principal Component Analysis
KW - Rest/physiology
KW - Transcranial Magnetic Stimulation
M3 - SCORING: Journal article
VL - 31
SP - 15284
EP - 15293
JO - J NEUROSCI
JF - J NEUROSCI
SN - 0270-6474
IS - 43
M1 - 43
ER -
