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Prefrontal cortex volume reductions and tic inhibition are unrelated in uncomplicated GTS adults

Standard

Prefrontal cortex volume reductions and tic inhibition are unrelated in uncomplicated GTS adults. / Ganos, Christos; Kühn, Simone; Kahl, Ursula; Schunke, Odette; Brandt, Valerie; Bäumer, Tobias; Thomalla, Götz; Haggard, Patrick; Münchau, Alexander.

in: J PSYCHOSOM RES, Jahrgang 76, Nr. 1, 2014, S. 84-7.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Ganos, C, Kühn, S, Kahl, U, Schunke, O, Brandt, V, Bäumer, T, Thomalla, G, Haggard, P & Münchau, A 2014, 'Prefrontal cortex volume reductions and tic inhibition are unrelated in uncomplicated GTS adults', J PSYCHOSOM RES, Jg. 76, Nr. 1, S. 84-7. https://doi.org/10.1016/j.jpsychores.2013.10.014

APA

Ganos, C., Kühn, S., Kahl, U., Schunke, O., Brandt, V., Bäumer, T., Thomalla, G., Haggard, P., & Münchau, A. (2014). Prefrontal cortex volume reductions and tic inhibition are unrelated in uncomplicated GTS adults. J PSYCHOSOM RES, 76(1), 84-7. https://doi.org/10.1016/j.jpsychores.2013.10.014

Vancouver

Ganos C, Kühn S, Kahl U, Schunke O, Brandt V, Bäumer T et al. Prefrontal cortex volume reductions and tic inhibition are unrelated in uncomplicated GTS adults. J PSYCHOSOM RES. 2014;76(1):84-7. https://doi.org/10.1016/j.jpsychores.2013.10.014

Bibtex

@article{9292a0fc54414e9db48526ad3046fa54,
title = "Prefrontal cortex volume reductions and tic inhibition are unrelated in uncomplicated GTS adults",
abstract = "BACKGROUND: Tics in Gilles de la Tourette syndrome (GTS) are repetitive patterned movements, resembling spontaneous motor behaviour, but escaping voluntary control. Previous studies hypothesised relations between structural alterations in prefrontal cortex of GTS adults and tic severity using voxel-based morphometry (VBM), but could not demonstrate a significant association. The relation between prefrontal cortex structure and tic inhibition has not been investigated.METHODS: Here, we used VBM to examine 14 GTS adults without associated comorbidities, and 15 healthy controls. We related structural alterations in GTS to clinical measures of tic severity and tic control.RESULTS: Grey matter volumes in the right inferior frontal gyrus and the left frontal pole were reduced in patients relative to healthy controls. These changes were not related to tic severity and tic inhibition.CONCLUSION: Prefrontal grey matter volume reductions in GTS adults are not related to state measures of tic phenomenology.",
author = "Christos Ganos and Simone K{\"u}hn and Ursula Kahl and Odette Schunke and Valerie Brandt and Tobias B{\"a}umer and G{\"o}tz Thomalla and Patrick Haggard and Alexander M{\"u}nchau",
note = "{\textcopyright} 2013.",
year = "2014",
doi = "10.1016/j.jpsychores.2013.10.014",
language = "English",
volume = "76",
pages = "84--7",
journal = "J PSYCHOSOM RES",
issn = "0022-3999",
publisher = "Elsevier Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Prefrontal cortex volume reductions and tic inhibition are unrelated in uncomplicated GTS adults

AU - Ganos, Christos

AU - Kühn, Simone

AU - Kahl, Ursula

AU - Schunke, Odette

AU - Brandt, Valerie

AU - Bäumer, Tobias

AU - Thomalla, Götz

AU - Haggard, Patrick

AU - Münchau, Alexander

N1 - © 2013.

PY - 2014

Y1 - 2014

N2 - BACKGROUND: Tics in Gilles de la Tourette syndrome (GTS) are repetitive patterned movements, resembling spontaneous motor behaviour, but escaping voluntary control. Previous studies hypothesised relations between structural alterations in prefrontal cortex of GTS adults and tic severity using voxel-based morphometry (VBM), but could not demonstrate a significant association. The relation between prefrontal cortex structure and tic inhibition has not been investigated.METHODS: Here, we used VBM to examine 14 GTS adults without associated comorbidities, and 15 healthy controls. We related structural alterations in GTS to clinical measures of tic severity and tic control.RESULTS: Grey matter volumes in the right inferior frontal gyrus and the left frontal pole were reduced in patients relative to healthy controls. These changes were not related to tic severity and tic inhibition.CONCLUSION: Prefrontal grey matter volume reductions in GTS adults are not related to state measures of tic phenomenology.

AB - BACKGROUND: Tics in Gilles de la Tourette syndrome (GTS) are repetitive patterned movements, resembling spontaneous motor behaviour, but escaping voluntary control. Previous studies hypothesised relations between structural alterations in prefrontal cortex of GTS adults and tic severity using voxel-based morphometry (VBM), but could not demonstrate a significant association. The relation between prefrontal cortex structure and tic inhibition has not been investigated.METHODS: Here, we used VBM to examine 14 GTS adults without associated comorbidities, and 15 healthy controls. We related structural alterations in GTS to clinical measures of tic severity and tic control.RESULTS: Grey matter volumes in the right inferior frontal gyrus and the left frontal pole were reduced in patients relative to healthy controls. These changes were not related to tic severity and tic inhibition.CONCLUSION: Prefrontal grey matter volume reductions in GTS adults are not related to state measures of tic phenomenology.

U2 - 10.1016/j.jpsychores.2013.10.014

DO - 10.1016/j.jpsychores.2013.10.014

M3 - SCORING: Journal article

C2 - 24360147

VL - 76

SP - 84

EP - 87

JO - J PSYCHOSOM RES

JF - J PSYCHOSOM RES

SN - 0022-3999

IS - 1

ER -