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Predictors of survival in patients with soft tissue surgical margin involvement at radical cystectomy.

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Predictors of survival in patients with soft tissue surgical margin involvement at radical cystectomy. / Xylinas, Evanguelos; Rink, Michael; Novara, Giacomo; Green, David A; Clozel, Thomas; Fritsche, Hans-Martin; Guillonneau, Bertrand; Lotan, Yair; Kassouf, Wassim; Tilki, Derya; Babjuk, Marek; Karakiewicz, Pierre I; Montorsi, Francesco; Abdennabi, Joual; Trinh, Quoc D; Svatek, Robert S; Scherr, Douglas S; Zerbib, Marc; Shariat, Shahrokh F.

in: ANN SURG ONCOL, Jahrgang 20, Nr. 3, 3, 2013, S. 1027-1034.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Xylinas, E, Rink, M, Novara, G, Green, DA, Clozel, T, Fritsche, H-M, Guillonneau, B, Lotan, Y, Kassouf, W, Tilki, D, Babjuk, M, Karakiewicz, PI, Montorsi, F, Abdennabi, J, Trinh, QD, Svatek, RS, Scherr, DS, Zerbib, M & Shariat, SF 2013, 'Predictors of survival in patients with soft tissue surgical margin involvement at radical cystectomy.', ANN SURG ONCOL, Jg. 20, Nr. 3, 3, S. 1027-1034. https://doi.org/10.1245/s10434-012-2708-5

APA

Xylinas, E., Rink, M., Novara, G., Green, D. A., Clozel, T., Fritsche, H-M., Guillonneau, B., Lotan, Y., Kassouf, W., Tilki, D., Babjuk, M., Karakiewicz, P. I., Montorsi, F., Abdennabi, J., Trinh, Q. D., Svatek, R. S., Scherr, D. S., Zerbib, M., & Shariat, S. F. (2013). Predictors of survival in patients with soft tissue surgical margin involvement at radical cystectomy. ANN SURG ONCOL, 20(3), 1027-1034. [3]. https://doi.org/10.1245/s10434-012-2708-5

Vancouver

Xylinas E, Rink M, Novara G, Green DA, Clozel T, Fritsche H-M et al. Predictors of survival in patients with soft tissue surgical margin involvement at radical cystectomy. ANN SURG ONCOL. 2013;20(3):1027-1034. 3. https://doi.org/10.1245/s10434-012-2708-5

Bibtex

@article{ace2d9e8f97f4c76a63dacab8e627ae7,
title = "Predictors of survival in patients with soft tissue surgical margin involvement at radical cystectomy.",
abstract = "BACKGROUND: The presence of positive soft tissue surgical margins (STSM) at radical cystectomy (RC) is rare. Although some patients with STSM experience disease recurrence rapidly, some have long-term local disease control. We sought to describe the oncologic outcomes, identify predictors, and assess the impact of location and multifocality in patients with positive STSMs at RC.METHODS: We retrospectively collected the data of 4,335 patients treated with RC and pelvic lymphadenectomy at 11 academic centers from 1981 to 2008. STSM was defined as the presence of tumor at inked areas of soft tissue on the RC specimen. Univariate and multivariate Cox regression models addressed recurrence-free survival and cancer-specific survival after surgery.RESULTS: STSM were identified in 231 patients (5%). Actuarial recurrence-free survival estimates at 2 and 5 years after RC were 26 ± 3 and 21 ± 3%, respectively. Actuarial cancer-specific survival estimates at 2 and 5 years after RC were 33 ± 3 and 25 ± 4%, respectively. Higher body mass index (p = 0.050), higher tumor stage (p = 0.017), presence of grade 3 disease (p = 0.046), lymphovascular invasion (p = 0.003), and lymph node involvement (p = 0.003) were all independently associated with disease recurrence. Furthermore, higher tumor stage (p = 0.015), lymphovascular invasion (p = 0.006), and lymph node involvement (p = 0.006) were independently associated with cancer specific mortality. Location and multifocality of STSM were not associated with outcomes.CONCLUSIONS: Although most patients with STSM at RC had poor outcomes, more than one-fifth had durable cancer control. Pathologic features associated with disease recurrence in the general RC population also stratify patients with STSM into differential risk groups.",
keywords = "Aged, Carcinoma, Transitional Cell, Cystectomy, Female, Follow-Up Studies, Humans, Lymph Node Excision, Lymphatic Metastasis, Male, Neoplasm Grading, Neoplasm Recurrence, Local, Neoplasm Staging, Prognosis, Retrospective Studies, Survival Rate, Urinary Bladder Neoplasms",
author = "Evanguelos Xylinas and Michael Rink and Giacomo Novara and Green, {David A} and Thomas Clozel and Hans-Martin Fritsche and Bertrand Guillonneau and Yair Lotan and Wassim Kassouf and Derya Tilki and Marek Babjuk and Karakiewicz, {Pierre I} and Francesco Montorsi and Joual Abdennabi and Trinh, {Quoc D} and Svatek, {Robert S} and Scherr, {Douglas S} and Marc Zerbib and Shariat, {Shahrokh F}",
year = "2013",
doi = "10.1245/s10434-012-2708-5",
language = "English",
volume = "20",
pages = "1027--1034",
journal = "ANN SURG ONCOL",
issn = "1068-9265",
publisher = "Springer New York",
number = "3",

}

RIS

TY - JOUR

T1 - Predictors of survival in patients with soft tissue surgical margin involvement at radical cystectomy.

AU - Xylinas, Evanguelos

AU - Rink, Michael

AU - Novara, Giacomo

AU - Green, David A

AU - Clozel, Thomas

AU - Fritsche, Hans-Martin

AU - Guillonneau, Bertrand

AU - Lotan, Yair

AU - Kassouf, Wassim

AU - Tilki, Derya

AU - Babjuk, Marek

AU - Karakiewicz, Pierre I

AU - Montorsi, Francesco

AU - Abdennabi, Joual

AU - Trinh, Quoc D

AU - Svatek, Robert S

AU - Scherr, Douglas S

AU - Zerbib, Marc

AU - Shariat, Shahrokh F

PY - 2013

Y1 - 2013

N2 - BACKGROUND: The presence of positive soft tissue surgical margins (STSM) at radical cystectomy (RC) is rare. Although some patients with STSM experience disease recurrence rapidly, some have long-term local disease control. We sought to describe the oncologic outcomes, identify predictors, and assess the impact of location and multifocality in patients with positive STSMs at RC.METHODS: We retrospectively collected the data of 4,335 patients treated with RC and pelvic lymphadenectomy at 11 academic centers from 1981 to 2008. STSM was defined as the presence of tumor at inked areas of soft tissue on the RC specimen. Univariate and multivariate Cox regression models addressed recurrence-free survival and cancer-specific survival after surgery.RESULTS: STSM were identified in 231 patients (5%). Actuarial recurrence-free survival estimates at 2 and 5 years after RC were 26 ± 3 and 21 ± 3%, respectively. Actuarial cancer-specific survival estimates at 2 and 5 years after RC were 33 ± 3 and 25 ± 4%, respectively. Higher body mass index (p = 0.050), higher tumor stage (p = 0.017), presence of grade 3 disease (p = 0.046), lymphovascular invasion (p = 0.003), and lymph node involvement (p = 0.003) were all independently associated with disease recurrence. Furthermore, higher tumor stage (p = 0.015), lymphovascular invasion (p = 0.006), and lymph node involvement (p = 0.006) were independently associated with cancer specific mortality. Location and multifocality of STSM were not associated with outcomes.CONCLUSIONS: Although most patients with STSM at RC had poor outcomes, more than one-fifth had durable cancer control. Pathologic features associated with disease recurrence in the general RC population also stratify patients with STSM into differential risk groups.

AB - BACKGROUND: The presence of positive soft tissue surgical margins (STSM) at radical cystectomy (RC) is rare. Although some patients with STSM experience disease recurrence rapidly, some have long-term local disease control. We sought to describe the oncologic outcomes, identify predictors, and assess the impact of location and multifocality in patients with positive STSMs at RC.METHODS: We retrospectively collected the data of 4,335 patients treated with RC and pelvic lymphadenectomy at 11 academic centers from 1981 to 2008. STSM was defined as the presence of tumor at inked areas of soft tissue on the RC specimen. Univariate and multivariate Cox regression models addressed recurrence-free survival and cancer-specific survival after surgery.RESULTS: STSM were identified in 231 patients (5%). Actuarial recurrence-free survival estimates at 2 and 5 years after RC were 26 ± 3 and 21 ± 3%, respectively. Actuarial cancer-specific survival estimates at 2 and 5 years after RC were 33 ± 3 and 25 ± 4%, respectively. Higher body mass index (p = 0.050), higher tumor stage (p = 0.017), presence of grade 3 disease (p = 0.046), lymphovascular invasion (p = 0.003), and lymph node involvement (p = 0.003) were all independently associated with disease recurrence. Furthermore, higher tumor stage (p = 0.015), lymphovascular invasion (p = 0.006), and lymph node involvement (p = 0.006) were independently associated with cancer specific mortality. Location and multifocality of STSM were not associated with outcomes.CONCLUSIONS: Although most patients with STSM at RC had poor outcomes, more than one-fifth had durable cancer control. Pathologic features associated with disease recurrence in the general RC population also stratify patients with STSM into differential risk groups.

KW - Aged

KW - Carcinoma, Transitional Cell

KW - Cystectomy

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Lymph Node Excision

KW - Lymphatic Metastasis

KW - Male

KW - Neoplasm Grading

KW - Neoplasm Recurrence, Local

KW - Neoplasm Staging

KW - Prognosis

KW - Retrospective Studies

KW - Survival Rate

KW - Urinary Bladder Neoplasms

U2 - 10.1245/s10434-012-2708-5

DO - 10.1245/s10434-012-2708-5

M3 - SCORING: Journal article

C2 - 23099729

VL - 20

SP - 1027

EP - 1034

JO - ANN SURG ONCOL

JF - ANN SURG ONCOL

SN - 1068-9265

IS - 3

M1 - 3

ER -