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Predictors of paravalvular regurgitation and permanent pacemaker implantation after TAVR with a next-generation self-expanding device

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Predictors of paravalvular regurgitation and permanent pacemaker implantation after TAVR with a next-generation self-expanding device. / Mauri, Victor; Deuschl, Florian; Frohn, Thomas; Schofer, Niklas; Linder, Matthias; Kuhn, Elmar; Schaefer, Andreas; Rudolph, Volker; Madershahian, Navid; Conradi, Lenard; Rudolph, Tanja K; Schäfer, Ulrich.

in: CLIN RES CARDIOL, Jahrgang 107, Nr. 8, 08.2018, S. 688-697.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Mauri, V, Deuschl, F, Frohn, T, Schofer, N, Linder, M, Kuhn, E, Schaefer, A, Rudolph, V, Madershahian, N, Conradi, L, Rudolph, TK & Schäfer, U 2018, 'Predictors of paravalvular regurgitation and permanent pacemaker implantation after TAVR with a next-generation self-expanding device', CLIN RES CARDIOL, Jg. 107, Nr. 8, S. 688-697. https://doi.org/10.1007/s00392-018-1235-1

APA

Mauri, V., Deuschl, F., Frohn, T., Schofer, N., Linder, M., Kuhn, E., Schaefer, A., Rudolph, V., Madershahian, N., Conradi, L., Rudolph, T. K., & Schäfer, U. (2018). Predictors of paravalvular regurgitation and permanent pacemaker implantation after TAVR with a next-generation self-expanding device. CLIN RES CARDIOL, 107(8), 688-697. https://doi.org/10.1007/s00392-018-1235-1

Vancouver

Mauri V, Deuschl F, Frohn T, Schofer N, Linder M, Kuhn E et al. Predictors of paravalvular regurgitation and permanent pacemaker implantation after TAVR with a next-generation self-expanding device. CLIN RES CARDIOL. 2018 Aug;107(8):688-697. https://doi.org/10.1007/s00392-018-1235-1

Bibtex

@article{e98d73a6290b41118f3035e386e1f8f5,
title = "Predictors of paravalvular regurgitation and permanent pacemaker implantation after TAVR with a next-generation self-expanding device",
abstract = "AIMS: To identify predictors of paravalvular regurgitation (PVR) and permanent pacemaker implantation (PPI) following TAVR with a next-generation self-expanding device.METHODS AND RESULTS: Device landing zone (DLZ) calcification, angiographic implantation depth, and baseline and procedural characteristics were analyzed in 212 patients being treated with the ACURATE neo aortic bioprosthesis. PVR was none/trace in 57.1% and ≥ mild in 42.9% (37% mild, 6% moderate). DLZ calcification (705 (IQR 240-624) vs. 382 (IQR 240-624) mm3; P < 0.001) as well as absolute calcium asymmetry (233 ± 159 vs. 151 ± 151 mm3; P < 0.001) was significantly higher in patients with PVR ≥ mild. On multivariate analysis, calcification of the aortic valve cusps (AVC) > 410.6 mm3 was independently associated with PVR ≥ mild. PPI rate was 10.3% (n = 20). Patients with and without need for PPI had similar total DLZ calcium volume (740 (IQR 378-920) vs. 536 (IQR 315-822) mm3; P = 0.263), but exhibited different calcium distribution patterns: LVOT calcium > 41.4 mm3 in the sector below the left coronary cusp (LVOTLC) was associated with increased PPI risk (26.9 vs. 7.7%; P = 0.008).CONCLUSIONS: The quantity of AVC calcium predicts residual PVR. Multivariable analysis identified LVOTLC calcium, pre-existing RBBB, and age > 82.7 years as independent predictors of PPI. Based on these risk factors, a patient's individual PPI risk can be stratified ranging from 3.8 to 100%.",
keywords = "Aged, 80 and over, Aortic Valve/diagnostic imaging, Aortic Valve Insufficiency/etiology, Aortic Valve Stenosis/diagnosis, Female, Humans, Male, Multidetector Computed Tomography, Pacemaker, Artificial, Retrospective Studies, Risk Factors, Self Expandable Metallic Stents/adverse effects, Severity of Illness Index, Transcatheter Aortic Valve Replacement/adverse effects",
author = "Victor Mauri and Florian Deuschl and Thomas Frohn and Niklas Schofer and Matthias Linder and Elmar Kuhn and Andreas Schaefer and Volker Rudolph and Navid Madershahian and Lenard Conradi and Rudolph, {Tanja K} and Ulrich Sch{\"a}fer",
year = "2018",
month = aug,
doi = "10.1007/s00392-018-1235-1",
language = "English",
volume = "107",
pages = "688--697",
journal = "CLIN RES CARDIOL",
issn = "1861-0684",
publisher = "D. Steinkopff-Verlag",
number = "8",

}

RIS

TY - JOUR

T1 - Predictors of paravalvular regurgitation and permanent pacemaker implantation after TAVR with a next-generation self-expanding device

AU - Mauri, Victor

AU - Deuschl, Florian

AU - Frohn, Thomas

AU - Schofer, Niklas

AU - Linder, Matthias

AU - Kuhn, Elmar

AU - Schaefer, Andreas

AU - Rudolph, Volker

AU - Madershahian, Navid

AU - Conradi, Lenard

AU - Rudolph, Tanja K

AU - Schäfer, Ulrich

PY - 2018/8

Y1 - 2018/8

N2 - AIMS: To identify predictors of paravalvular regurgitation (PVR) and permanent pacemaker implantation (PPI) following TAVR with a next-generation self-expanding device.METHODS AND RESULTS: Device landing zone (DLZ) calcification, angiographic implantation depth, and baseline and procedural characteristics were analyzed in 212 patients being treated with the ACURATE neo aortic bioprosthesis. PVR was none/trace in 57.1% and ≥ mild in 42.9% (37% mild, 6% moderate). DLZ calcification (705 (IQR 240-624) vs. 382 (IQR 240-624) mm3; P < 0.001) as well as absolute calcium asymmetry (233 ± 159 vs. 151 ± 151 mm3; P < 0.001) was significantly higher in patients with PVR ≥ mild. On multivariate analysis, calcification of the aortic valve cusps (AVC) > 410.6 mm3 was independently associated with PVR ≥ mild. PPI rate was 10.3% (n = 20). Patients with and without need for PPI had similar total DLZ calcium volume (740 (IQR 378-920) vs. 536 (IQR 315-822) mm3; P = 0.263), but exhibited different calcium distribution patterns: LVOT calcium > 41.4 mm3 in the sector below the left coronary cusp (LVOTLC) was associated with increased PPI risk (26.9 vs. 7.7%; P = 0.008).CONCLUSIONS: The quantity of AVC calcium predicts residual PVR. Multivariable analysis identified LVOTLC calcium, pre-existing RBBB, and age > 82.7 years as independent predictors of PPI. Based on these risk factors, a patient's individual PPI risk can be stratified ranging from 3.8 to 100%.

AB - AIMS: To identify predictors of paravalvular regurgitation (PVR) and permanent pacemaker implantation (PPI) following TAVR with a next-generation self-expanding device.METHODS AND RESULTS: Device landing zone (DLZ) calcification, angiographic implantation depth, and baseline and procedural characteristics were analyzed in 212 patients being treated with the ACURATE neo aortic bioprosthesis. PVR was none/trace in 57.1% and ≥ mild in 42.9% (37% mild, 6% moderate). DLZ calcification (705 (IQR 240-624) vs. 382 (IQR 240-624) mm3; P < 0.001) as well as absolute calcium asymmetry (233 ± 159 vs. 151 ± 151 mm3; P < 0.001) was significantly higher in patients with PVR ≥ mild. On multivariate analysis, calcification of the aortic valve cusps (AVC) > 410.6 mm3 was independently associated with PVR ≥ mild. PPI rate was 10.3% (n = 20). Patients with and without need for PPI had similar total DLZ calcium volume (740 (IQR 378-920) vs. 536 (IQR 315-822) mm3; P = 0.263), but exhibited different calcium distribution patterns: LVOT calcium > 41.4 mm3 in the sector below the left coronary cusp (LVOTLC) was associated with increased PPI risk (26.9 vs. 7.7%; P = 0.008).CONCLUSIONS: The quantity of AVC calcium predicts residual PVR. Multivariable analysis identified LVOTLC calcium, pre-existing RBBB, and age > 82.7 years as independent predictors of PPI. Based on these risk factors, a patient's individual PPI risk can be stratified ranging from 3.8 to 100%.

KW - Aged, 80 and over

KW - Aortic Valve/diagnostic imaging

KW - Aortic Valve Insufficiency/etiology

KW - Aortic Valve Stenosis/diagnosis

KW - Female

KW - Humans

KW - Male

KW - Multidetector Computed Tomography

KW - Pacemaker, Artificial

KW - Retrospective Studies

KW - Risk Factors

KW - Self Expandable Metallic Stents/adverse effects

KW - Severity of Illness Index

KW - Transcatheter Aortic Valve Replacement/adverse effects

U2 - 10.1007/s00392-018-1235-1

DO - 10.1007/s00392-018-1235-1

M3 - SCORING: Journal article

C2 - 29667013

VL - 107

SP - 688

EP - 697

JO - CLIN RES CARDIOL

JF - CLIN RES CARDIOL

SN - 1861-0684

IS - 8

ER -