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Predictors of complications in therapeutic plasma exchange

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Predictors of complications in therapeutic plasma exchange. / Bramlage, Carsten P; Schröder, Katharina; Bramlage, Peter; Ahrens, Katharina; Zapf, Antonia; Müller, Gerhard Anton; Koziolek, Michael J.

in: J CLIN APHERESIS, Jahrgang 24, Nr. 6, 2009, S. 225-231.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Bramlage, CP, Schröder, K, Bramlage, P, Ahrens, K, Zapf, A, Müller, GA & Koziolek, MJ 2009, 'Predictors of complications in therapeutic plasma exchange', J CLIN APHERESIS, Jg. 24, Nr. 6, S. 225-231. https://doi.org/10.1002/jca.20217

APA

Bramlage, C. P., Schröder, K., Bramlage, P., Ahrens, K., Zapf, A., Müller, G. A., & Koziolek, M. J. (2009). Predictors of complications in therapeutic plasma exchange. J CLIN APHERESIS, 24(6), 225-231. https://doi.org/10.1002/jca.20217

Vancouver

Bramlage CP, Schröder K, Bramlage P, Ahrens K, Zapf A, Müller GA et al. Predictors of complications in therapeutic plasma exchange. J CLIN APHERESIS. 2009;24(6):225-231. https://doi.org/10.1002/jca.20217

Bibtex

@article{ce257b0bcb8340df9c810dca1c6f9d79,
title = "Predictors of complications in therapeutic plasma exchange",
abstract = "Plasma exchange (PE) is used for blood purification to modulate proteins involved in pathological processes. As the number of patients receiving PE treatment and the heterogeneity of the underlying diseases is steadily increasing, we evaluated the most frequent complications and analyzed causes leading to adverse reactions. 883 PE procedures in 113 patients between the years 2000 to 2006 were retrospectively analyzed with respect to complications. Additionally, underlying diseases and settings of PE procedure were analyzed to identify high-risk patients and respective PE settings. A total of 226 adverse reactions were recorded (25.6% of all PE procedures). Most complications were mild (n = 121, 13.7%) or moderate (n = 98, 11.0%). In seven cases (n = 7, 0.7%), severe, life-threatening adverse events were induced by PE either due to severe allergic reactions (n = 4, 0.5%) or to sepsis (n = 3, 0.3%). Patients with neurologic diseases had a significantly higher risk to develop complications compared to those with internal diseases (P = 0.013). This was due to a higher rate of PE associated adverse events (in particular hypotension) and complications associated with vascular access. Among patients from internal medicine those with hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) had the highest risk to develop complications. Patients with neurological diseases compared to those with medical conditions and patients with HUS/TTP compared to those with other diseases had a higher risk to develop complications. However, severe adverse events are rare. Thus, PE seems to be a safe and recommendable procedure.",
keywords = "Adult, Aged, Female, Hemolytic-Uremic Syndrome, Humans, Hypersensitivity, Hypotension, Male, Middle Aged, Plasma Exchange, Purpura, Thrombotic Thrombocytopenic, Retrospective Studies, Risk Factors, Journal Article",
author = "Bramlage, {Carsten P} and Katharina Schr{\"o}der and Peter Bramlage and Katharina Ahrens and Antonia Zapf and M{\"u}ller, {Gerhard Anton} and Koziolek, {Michael J}",
year = "2009",
doi = "10.1002/jca.20217",
language = "English",
volume = "24",
pages = "225--231",
journal = "J CLIN APHERESIS",
issn = "0733-2459",
publisher = "Wiley-Liss Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - Predictors of complications in therapeutic plasma exchange

AU - Bramlage, Carsten P

AU - Schröder, Katharina

AU - Bramlage, Peter

AU - Ahrens, Katharina

AU - Zapf, Antonia

AU - Müller, Gerhard Anton

AU - Koziolek, Michael J

PY - 2009

Y1 - 2009

N2 - Plasma exchange (PE) is used for blood purification to modulate proteins involved in pathological processes. As the number of patients receiving PE treatment and the heterogeneity of the underlying diseases is steadily increasing, we evaluated the most frequent complications and analyzed causes leading to adverse reactions. 883 PE procedures in 113 patients between the years 2000 to 2006 were retrospectively analyzed with respect to complications. Additionally, underlying diseases and settings of PE procedure were analyzed to identify high-risk patients and respective PE settings. A total of 226 adverse reactions were recorded (25.6% of all PE procedures). Most complications were mild (n = 121, 13.7%) or moderate (n = 98, 11.0%). In seven cases (n = 7, 0.7%), severe, life-threatening adverse events were induced by PE either due to severe allergic reactions (n = 4, 0.5%) or to sepsis (n = 3, 0.3%). Patients with neurologic diseases had a significantly higher risk to develop complications compared to those with internal diseases (P = 0.013). This was due to a higher rate of PE associated adverse events (in particular hypotension) and complications associated with vascular access. Among patients from internal medicine those with hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) had the highest risk to develop complications. Patients with neurological diseases compared to those with medical conditions and patients with HUS/TTP compared to those with other diseases had a higher risk to develop complications. However, severe adverse events are rare. Thus, PE seems to be a safe and recommendable procedure.

AB - Plasma exchange (PE) is used for blood purification to modulate proteins involved in pathological processes. As the number of patients receiving PE treatment and the heterogeneity of the underlying diseases is steadily increasing, we evaluated the most frequent complications and analyzed causes leading to adverse reactions. 883 PE procedures in 113 patients between the years 2000 to 2006 were retrospectively analyzed with respect to complications. Additionally, underlying diseases and settings of PE procedure were analyzed to identify high-risk patients and respective PE settings. A total of 226 adverse reactions were recorded (25.6% of all PE procedures). Most complications were mild (n = 121, 13.7%) or moderate (n = 98, 11.0%). In seven cases (n = 7, 0.7%), severe, life-threatening adverse events were induced by PE either due to severe allergic reactions (n = 4, 0.5%) or to sepsis (n = 3, 0.3%). Patients with neurologic diseases had a significantly higher risk to develop complications compared to those with internal diseases (P = 0.013). This was due to a higher rate of PE associated adverse events (in particular hypotension) and complications associated with vascular access. Among patients from internal medicine those with hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) had the highest risk to develop complications. Patients with neurological diseases compared to those with medical conditions and patients with HUS/TTP compared to those with other diseases had a higher risk to develop complications. However, severe adverse events are rare. Thus, PE seems to be a safe and recommendable procedure.

KW - Adult

KW - Aged

KW - Female

KW - Hemolytic-Uremic Syndrome

KW - Humans

KW - Hypersensitivity

KW - Hypotension

KW - Male

KW - Middle Aged

KW - Plasma Exchange

KW - Purpura, Thrombotic Thrombocytopenic

KW - Retrospective Studies

KW - Risk Factors

KW - Journal Article

U2 - 10.1002/jca.20217

DO - 10.1002/jca.20217

M3 - SCORING: Journal article

C2 - 19890911

VL - 24

SP - 225

EP - 231

JO - J CLIN APHERESIS

JF - J CLIN APHERESIS

SN - 0733-2459

IS - 6

ER -