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Predictive timing functions of cortical beta oscillations are impaired in Parkinson´s disease and influenced by L-DOPA and deep brain stimulation of the subthalamic nucleus

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Predictive timing functions of cortical beta oscillations are impaired in Parkinson´s disease and influenced by L-DOPA and deep brain stimulation of the subthalamic nucleus. / Gulberti, Alessandro; Moll, Christian; Hamel, Wolfgang; Buhmann, Carsten; Köppen, Johannes; Boelmans, Kai; Zittel-Dirks, Simone; Gerloff, Christian; Westphal, Manfred; Schneider, Till R.; Engel, Andreas Karl.

in: NEUROIMAGE-CLIN, Nr. 9, 09.2015, S. 436-449.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Gulberti, A, Moll, C, Hamel, W, Buhmann, C, Köppen, J, Boelmans, K, Zittel-Dirks, S, Gerloff, C, Westphal, M, Schneider, TR & Engel, AK 2015, 'Predictive timing functions of cortical beta oscillations are impaired in Parkinson´s disease and influenced by L-DOPA and deep brain stimulation of the subthalamic nucleus', NEUROIMAGE-CLIN, Nr. 9, S. 436-449. https://doi.org/10.1016/j.nicl.2015.09.013

APA

Gulberti, A., Moll, C., Hamel, W., Buhmann, C., Köppen, J., Boelmans, K., Zittel-Dirks, S., Gerloff, C., Westphal, M., Schneider, T. R., & Engel, A. K. (2015). Predictive timing functions of cortical beta oscillations are impaired in Parkinson´s disease and influenced by L-DOPA and deep brain stimulation of the subthalamic nucleus. NEUROIMAGE-CLIN, (9), 436-449. https://doi.org/10.1016/j.nicl.2015.09.013

Vancouver

Gulberti A, Moll C, Hamel W, Buhmann C, Köppen J, Boelmans K et al. Predictive timing functions of cortical beta oscillations are impaired in Parkinson´s disease and influenced by L-DOPA and deep brain stimulation of the subthalamic nucleus. NEUROIMAGE-CLIN. 2015 Sep;(9):436-449. https://doi.org/10.1016/j.nicl.2015.09.013

Bibtex

@article{483964a9451b4899b93ecf6deb659648,
title = "Predictive timing functions of cortical beta oscillations are impaired in Parkinson´s disease and influenced by L-DOPA and deep brain stimulation of the subthalamic nucleus",
abstract = "Cortex-basal ganglia circuits participate in motor timing and temporal perception, and are important for the dynamic configuration of sensorimotor networks in response to exogenous demands. In Parkinson's disease (PD) patients, rhythmic auditory stimulation (RAS) induces motor performance benefits. Hitherto, little is known concerning contributions of the basal ganglia to sensory facilitation and cortical responses to RAS in PD. Therefore, we conducted an EEG study in 12 PD patients before and after surgery for subthalamic nucleus deep brain stimulation (STN-DBS) and in 12 age-matched controls. Here we investigated the effects of levodopa and STN-DBS on resting-state EEG and on the cortical-response profile to slow and fast RAS in a passive-listening paradigm focusing on beta-band oscillations, which are important for auditory–motor coupling. The beta-modulation profile to RAS in healthy participants was characterized by local peaks preceding and following auditory stimuli. In PD patients RAS failed to induce pre-stimulus beta increases. The absence of pre-stimulus beta-band modulation may contribute to impaired rhythm perception in PD. Moreover, post-stimulus beta-band responses were highly abnormal during fast RAS in PD patients. Treatment with levodopa and STN-DBS reinstated a post-stimulus beta-modulation profile similar to controls, while STN-DBS reduced beta-band power in the resting-state. The treatment-sensitivity of beta oscillations suggests that STN-DBS may specifically improve timekeeping functions of cortical beta oscillations during fast auditory pacing.",
author = "Alessandro Gulberti and Christian Moll and Wolfgang Hamel and Carsten Buhmann and Johannes K{\"o}ppen and Kai Boelmans and Simone Zittel-Dirks and Christian Gerloff and Manfred Westphal and Schneider, {Till R.} and Engel, {Andreas Karl}",
year = "2015",
month = sep,
doi = "10.1016/j.nicl.2015.09.013",
language = "Deutsch",
pages = "436--449",
journal = "NEUROIMAGE-CLIN",
issn = "2213-1582",
publisher = "Elsevier BV",
number = "9",

}

RIS

TY - JOUR

T1 - Predictive timing functions of cortical beta oscillations are impaired in Parkinson´s disease and influenced by L-DOPA and deep brain stimulation of the subthalamic nucleus

AU - Gulberti, Alessandro

AU - Moll, Christian

AU - Hamel, Wolfgang

AU - Buhmann, Carsten

AU - Köppen, Johannes

AU - Boelmans, Kai

AU - Zittel-Dirks, Simone

AU - Gerloff, Christian

AU - Westphal, Manfred

AU - Schneider, Till R.

AU - Engel, Andreas Karl

PY - 2015/9

Y1 - 2015/9

N2 - Cortex-basal ganglia circuits participate in motor timing and temporal perception, and are important for the dynamic configuration of sensorimotor networks in response to exogenous demands. In Parkinson's disease (PD) patients, rhythmic auditory stimulation (RAS) induces motor performance benefits. Hitherto, little is known concerning contributions of the basal ganglia to sensory facilitation and cortical responses to RAS in PD. Therefore, we conducted an EEG study in 12 PD patients before and after surgery for subthalamic nucleus deep brain stimulation (STN-DBS) and in 12 age-matched controls. Here we investigated the effects of levodopa and STN-DBS on resting-state EEG and on the cortical-response profile to slow and fast RAS in a passive-listening paradigm focusing on beta-band oscillations, which are important for auditory–motor coupling. The beta-modulation profile to RAS in healthy participants was characterized by local peaks preceding and following auditory stimuli. In PD patients RAS failed to induce pre-stimulus beta increases. The absence of pre-stimulus beta-band modulation may contribute to impaired rhythm perception in PD. Moreover, post-stimulus beta-band responses were highly abnormal during fast RAS in PD patients. Treatment with levodopa and STN-DBS reinstated a post-stimulus beta-modulation profile similar to controls, while STN-DBS reduced beta-band power in the resting-state. The treatment-sensitivity of beta oscillations suggests that STN-DBS may specifically improve timekeeping functions of cortical beta oscillations during fast auditory pacing.

AB - Cortex-basal ganglia circuits participate in motor timing and temporal perception, and are important for the dynamic configuration of sensorimotor networks in response to exogenous demands. In Parkinson's disease (PD) patients, rhythmic auditory stimulation (RAS) induces motor performance benefits. Hitherto, little is known concerning contributions of the basal ganglia to sensory facilitation and cortical responses to RAS in PD. Therefore, we conducted an EEG study in 12 PD patients before and after surgery for subthalamic nucleus deep brain stimulation (STN-DBS) and in 12 age-matched controls. Here we investigated the effects of levodopa and STN-DBS on resting-state EEG and on the cortical-response profile to slow and fast RAS in a passive-listening paradigm focusing on beta-band oscillations, which are important for auditory–motor coupling. The beta-modulation profile to RAS in healthy participants was characterized by local peaks preceding and following auditory stimuli. In PD patients RAS failed to induce pre-stimulus beta increases. The absence of pre-stimulus beta-band modulation may contribute to impaired rhythm perception in PD. Moreover, post-stimulus beta-band responses were highly abnormal during fast RAS in PD patients. Treatment with levodopa and STN-DBS reinstated a post-stimulus beta-modulation profile similar to controls, while STN-DBS reduced beta-band power in the resting-state. The treatment-sensitivity of beta oscillations suggests that STN-DBS may specifically improve timekeeping functions of cortical beta oscillations during fast auditory pacing.

U2 - 10.1016/j.nicl.2015.09.013

DO - 10.1016/j.nicl.2015.09.013

M3 - SCORING: Zeitschriftenaufsatz

SP - 436

EP - 449

JO - NEUROIMAGE-CLIN

JF - NEUROIMAGE-CLIN

SN - 2213-1582

IS - 9

ER -