Predictive factors for lymph node metastases in vulvar cancer. An analysis of the AGO-CaRE-1 multicenter study
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Predictive factors for lymph node metastases in vulvar cancer. An analysis of the AGO-CaRE-1 multicenter study. / Klapdor, Rüdiger; Wölber, Linn; Hanker, Lars; Schmalfeldt, Barbara; Canzler, Ulrich; Fehm, Tanja; Luyten, Alexander; Hellriegel, Martin; Kosse, Jens; Heiss, Christoph; Hantschmann, Peer; Mallmann, Peter; Tanner, Berno; Pfisterer, Jacobus; Jückstock, Julia; Hilpert, Felix; de Gregorio, Nikolaus; Hillemanns, Peter; Fürst, Sophie Teresa; Mahner, Sven.
in: GYNECOL ONCOL, Jahrgang 154, Nr. 3, 09.2019, S. 565-570.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Predictive factors for lymph node metastases in vulvar cancer. An analysis of the AGO-CaRE-1 multicenter study
AU - Klapdor, Rüdiger
AU - Wölber, Linn
AU - Hanker, Lars
AU - Schmalfeldt, Barbara
AU - Canzler, Ulrich
AU - Fehm, Tanja
AU - Luyten, Alexander
AU - Hellriegel, Martin
AU - Kosse, Jens
AU - Heiss, Christoph
AU - Hantschmann, Peer
AU - Mallmann, Peter
AU - Tanner, Berno
AU - Pfisterer, Jacobus
AU - Jückstock, Julia
AU - Hilpert, Felix
AU - de Gregorio, Nikolaus
AU - Hillemanns, Peter
AU - Fürst, Sophie Teresa
AU - Mahner, Sven
N1 - Copyright © 2019 Elsevier Inc. All rights reserved.
PY - 2019/9
Y1 - 2019/9
N2 - BACKGROUND: Lymph node (LN) metastasis is the most important prognostic factor in primary vulvar cancer. Assessing risk factors for the incidence and extent of LN metastases may help to select the optimal treatment strategy for each individual patient.METHODS: In a subgroup analysis of the large multicenter AGO-CaRE-1 study we included all patients treated with radical groin dissection. Univariate and multivariate regression analyses were performed in order to detect factors associated with the prevalence and extent of nodal involvement.RESULTS: In total, 1162 patients were analyzed. Univariate analyses detected age, ECOG as well as multiple tumor characteristics such as FIGO stage, grading, depth of invasion, tumor diameter, and (lymph)vascular space invasion to be related with the prevalence of LN metastases. Interestingly, only tumor stage, tumor diameter and depth of infiltration were found to be significantly associated with the number of LN metastases. In multivariate analysis, age (OR 1.03), lymphvascular space invasion (OR 4.97), tumor stage (OR 2.22) and depth of infiltration (OR 1.08) showed an association with the prevalence of LN metastases. Regarding the number of metastatic LNs, only tumor stage (OR 2.21) or, if excluded, tumor diameter (OR 1.02) were tested significant.CONCLUSION: This large analysis of the multicenter AGO-CaRE-1-study identified lymphvascular space invasion, tumor stage, and depth of infiltration as factors with the strongest association regarding the prevalence of LN metastasis. Interestingly, tumor stage or, if excluded, tumor diameter were the only factors associated with the prevalence as well as the extent of LN metastases.
AB - BACKGROUND: Lymph node (LN) metastasis is the most important prognostic factor in primary vulvar cancer. Assessing risk factors for the incidence and extent of LN metastases may help to select the optimal treatment strategy for each individual patient.METHODS: In a subgroup analysis of the large multicenter AGO-CaRE-1 study we included all patients treated with radical groin dissection. Univariate and multivariate regression analyses were performed in order to detect factors associated with the prevalence and extent of nodal involvement.RESULTS: In total, 1162 patients were analyzed. Univariate analyses detected age, ECOG as well as multiple tumor characteristics such as FIGO stage, grading, depth of invasion, tumor diameter, and (lymph)vascular space invasion to be related with the prevalence of LN metastases. Interestingly, only tumor stage, tumor diameter and depth of infiltration were found to be significantly associated with the number of LN metastases. In multivariate analysis, age (OR 1.03), lymphvascular space invasion (OR 4.97), tumor stage (OR 2.22) and depth of infiltration (OR 1.08) showed an association with the prevalence of LN metastases. Regarding the number of metastatic LNs, only tumor stage (OR 2.21) or, if excluded, tumor diameter (OR 1.02) were tested significant.CONCLUSION: This large analysis of the multicenter AGO-CaRE-1-study identified lymphvascular space invasion, tumor stage, and depth of infiltration as factors with the strongest association regarding the prevalence of LN metastasis. Interestingly, tumor stage or, if excluded, tumor diameter were the only factors associated with the prevalence as well as the extent of LN metastases.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Analysis of Variance
KW - Cohort Studies
KW - Female
KW - Groin/surgery
KW - Humans
KW - Lymph Node Excision
KW - Lymph Nodes/pathology
KW - Lymphatic Metastasis
KW - Middle Aged
KW - Multivariate Analysis
KW - Neoplasm Invasiveness
KW - Neoplasm Staging
KW - Predictive Value of Tests
KW - Retrospective Studies
KW - Vulvar Neoplasms/pathology
U2 - 10.1016/j.ygyno.2019.06.013
DO - 10.1016/j.ygyno.2019.06.013
M3 - SCORING: Journal article
C2 - 31227222
VL - 154
SP - 565
EP - 570
JO - GYNECOL ONCOL
JF - GYNECOL ONCOL
SN - 0090-8258
IS - 3
ER -
