Predicting infarction within the diffusion-weighted imaging lesion: does the mean transit time have added value?
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Predicting infarction within the diffusion-weighted imaging lesion: does the mean transit time have added value? / Carrera, Emmanuel; Jones, P Simon; Alawneh, Josef A; Irene, Klærke Mikkelsen; Cho, Tae-Hee; Siemonsen, Suzanne; Guadagno, Joseph V; Mouridsen, Kim; Ribe, Lars; Hjort, Niels; Fryer, Tim D; Carpenter, T Adrian; Aigbirhio, Franklin I; Fiehler, Jens; Nighoghossian, Norbert; Warburton, Elizabeth A; Ostergaard, Leif; Baron, Jean-Claude.
in: STROKE, Jahrgang 42, Nr. 6, 6, 01.06.2011, S. 1602-1607.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Predicting infarction within the diffusion-weighted imaging lesion: does the mean transit time have added value?
AU - Carrera, Emmanuel
AU - Jones, P Simon
AU - Alawneh, Josef A
AU - Irene, Klærke Mikkelsen
AU - Cho, Tae-Hee
AU - Siemonsen, Suzanne
AU - Guadagno, Joseph V
AU - Mouridsen, Kim
AU - Ribe, Lars
AU - Hjort, Niels
AU - Fryer, Tim D
AU - Carpenter, T Adrian
AU - Aigbirhio, Franklin I
AU - Fiehler, Jens
AU - Nighoghossian, Norbert
AU - Warburton, Elizabeth A
AU - Ostergaard, Leif
AU - Baron, Jean-Claude
PY - 2011/6/1
Y1 - 2011/6/1
N2 - There is ample evidence that in anterior circulation stroke, the diffusion-weighted imaging (DWI) lesion may escape infarction and thus is not a reliable infarct predictor. In this study, we assessed the predictive value of the mean transit time (MTT) for final infarction within the DWI lesion, first in patients scanned back-to-back with 15O-positron emission tomography and MR (DWI and perfusion-weighted imaging; "Cambridge sample") within 7 to 21 hours of clinical onset, then in a large sample of patients with anterior circulation stroke receiving DWI and perfusion-weighted imaging within 12 hours (85% within 6 hours; "I-KNOW sample").
AB - There is ample evidence that in anterior circulation stroke, the diffusion-weighted imaging (DWI) lesion may escape infarction and thus is not a reliable infarct predictor. In this study, we assessed the predictive value of the mean transit time (MTT) for final infarction within the DWI lesion, first in patients scanned back-to-back with 15O-positron emission tomography and MR (DWI and perfusion-weighted imaging; "Cambridge sample") within 7 to 21 hours of clinical onset, then in a large sample of patients with anterior circulation stroke receiving DWI and perfusion-weighted imaging within 12 hours (85% within 6 hours; "I-KNOW sample").
KW - Humans
KW - Prospective Studies
KW - Time Factors
KW - ROC Curve
KW - Cerebral Infarction/pathology
KW - Cerebrovascular Circulation/physiology
KW - Diffusion Magnetic Resonance Imaging/methods
KW - Humans
KW - Prospective Studies
KW - Time Factors
KW - ROC Curve
KW - Cerebral Infarction/pathology
KW - Cerebrovascular Circulation/physiology
KW - Diffusion Magnetic Resonance Imaging/methods
U2 - 10.1161/STROKEAHA.110.606970
DO - 10.1161/STROKEAHA.110.606970
M3 - SCORING: Journal article
C2 - 21512183
VL - 42
SP - 1602
EP - 1607
JO - STROKE
JF - STROKE
SN - 0039-2499
IS - 6
M1 - 6
ER -