Preclinical models to study patient-derived circulating tumor cells and metastasis
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Preclinical models to study patient-derived circulating tumor cells and metastasis. / Suvilesh, Kanve N; Manjunath, Yariswamy; Pantel, Klaus; Kaifi, Jussuf T.
in: TRENDS CANCER, Jahrgang 9, Nr. 4, 04.2023, S. 355-371.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Preclinical models to study patient-derived circulating tumor cells and metastasis
AU - Suvilesh, Kanve N
AU - Manjunath, Yariswamy
AU - Pantel, Klaus
AU - Kaifi, Jussuf T
N1 - Published by Elsevier Inc.
PY - 2023/4
Y1 - 2023/4
N2 - Circulating tumor cells (CTCs) that are detached from the tumor can be precursors of metastasis. The majority of studies focus on enumeration of CTCs from patient blood to predict recurrence and therapy outcomes. Very few studies have managed to expand CTCs to investigate their functional dynamics with respect to genetic changes, tumorigenic potential, and response to drug treatment. A growing amount of evidence based on successful CTC expansion has revealed novel therapeutic targets that are associated with the process of metastasis. In this review, we summarize the successes, challenges, and limitations that collectively contribute to the better understanding of metastasis using patient-derived CTCs as blood-borne seeds of metastasis. The roadblocks and future avenues to move CTC-based scientific discoveries forward are also discussed.
AB - Circulating tumor cells (CTCs) that are detached from the tumor can be precursors of metastasis. The majority of studies focus on enumeration of CTCs from patient blood to predict recurrence and therapy outcomes. Very few studies have managed to expand CTCs to investigate their functional dynamics with respect to genetic changes, tumorigenic potential, and response to drug treatment. A growing amount of evidence based on successful CTC expansion has revealed novel therapeutic targets that are associated with the process of metastasis. In this review, we summarize the successes, challenges, and limitations that collectively contribute to the better understanding of metastasis using patient-derived CTCs as blood-borne seeds of metastasis. The roadblocks and future avenues to move CTC-based scientific discoveries forward are also discussed.
U2 - 10.1016/j.trecan.2023.01.004
DO - 10.1016/j.trecan.2023.01.004
M3 - SCORING: Review article
C2 - 36759267
VL - 9
SP - 355
EP - 371
JO - TRENDS CANCER
JF - TRENDS CANCER
SN - 2405-8025
IS - 4
ER -