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Potentiation of beta-adrenergic inotropic response by pyruvate in failing human myocardium.

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Potentiation of beta-adrenergic inotropic response by pyruvate in failing human myocardium. / Hermann, Hans Peter; Zeitz, Oliver; Lehnart, Stephan E; Keweloh, Boris; Datz, Nicolin; Hasenfuss, Gerd; Janssen, Paul M L.

in: CARDIOVASC RES, Jahrgang 53, Nr. 1, 1, 2002, S. 116-123.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Hermann, HP, Zeitz, O, Lehnart, SE, Keweloh, B, Datz, N, Hasenfuss, G & Janssen, PML 2002, 'Potentiation of beta-adrenergic inotropic response by pyruvate in failing human myocardium.', CARDIOVASC RES, Jg. 53, Nr. 1, 1, S. 116-123. <http://www.ncbi.nlm.nih.gov/pubmed/11744019?dopt=Citation>

APA

Hermann, H. P., Zeitz, O., Lehnart, S. E., Keweloh, B., Datz, N., Hasenfuss, G., & Janssen, P. M. L. (2002). Potentiation of beta-adrenergic inotropic response by pyruvate in failing human myocardium. CARDIOVASC RES, 53(1), 116-123. [1]. http://www.ncbi.nlm.nih.gov/pubmed/11744019?dopt=Citation

Vancouver

Hermann HP, Zeitz O, Lehnart SE, Keweloh B, Datz N, Hasenfuss G et al. Potentiation of beta-adrenergic inotropic response by pyruvate in failing human myocardium. CARDIOVASC RES. 2002;53(1):116-123. 1.

Bibtex

@article{ec061b4a12b34b169b4f82e7f0a9c312,
title = "Potentiation of beta-adrenergic inotropic response by pyruvate in failing human myocardium.",
abstract = "BACKGROUND: Pyruvate has been shown to increase contractile function in isolated myocardium and to improve hemodynamics in patients with congestive heart failure. We tested the hypothesis that pyruvate potentiates the inotropic response to beta-adrenergic stimulation and to elevated extracellular calcium, since this may be of potential therapeutic value in the clinical setting of acute heart failure in order to circumvent deleterious effects on energy demand as can occur during catecholamine therapy. METHODS AND RESULTS: We investigated isometrically contracting isolated multicellular muscle preparations from terminal failing human hearts at 37 degrees C, pH 7.4, and a stimulation frequency of 1 Hz. At an extracellular calcium concentration of 1.25 mM, pyruvate (10 mM) alone increased developed force (F(dev)) from 9.0+/-2.3 to 21.1+/-4.3 mN/mm(2) (n=9, P",
author = "Hermann, {Hans Peter} and Oliver Zeitz and Lehnart, {Stephan E} and Boris Keweloh and Nicolin Datz and Gerd Hasenfuss and Janssen, {Paul M L}",
year = "2002",
language = "Deutsch",
volume = "53",
pages = "116--123",
journal = "CARDIOVASC RES",
issn = "0008-6363",
publisher = "Oxford University Press",
number = "1",

}

RIS

TY - JOUR

T1 - Potentiation of beta-adrenergic inotropic response by pyruvate in failing human myocardium.

AU - Hermann, Hans Peter

AU - Zeitz, Oliver

AU - Lehnart, Stephan E

AU - Keweloh, Boris

AU - Datz, Nicolin

AU - Hasenfuss, Gerd

AU - Janssen, Paul M L

PY - 2002

Y1 - 2002

N2 - BACKGROUND: Pyruvate has been shown to increase contractile function in isolated myocardium and to improve hemodynamics in patients with congestive heart failure. We tested the hypothesis that pyruvate potentiates the inotropic response to beta-adrenergic stimulation and to elevated extracellular calcium, since this may be of potential therapeutic value in the clinical setting of acute heart failure in order to circumvent deleterious effects on energy demand as can occur during catecholamine therapy. METHODS AND RESULTS: We investigated isometrically contracting isolated multicellular muscle preparations from terminal failing human hearts at 37 degrees C, pH 7.4, and a stimulation frequency of 1 Hz. At an extracellular calcium concentration of 1.25 mM, pyruvate (10 mM) alone increased developed force (F(dev)) from 9.0+/-2.3 to 21.1+/-4.3 mN/mm(2) (n=9, P

AB - BACKGROUND: Pyruvate has been shown to increase contractile function in isolated myocardium and to improve hemodynamics in patients with congestive heart failure. We tested the hypothesis that pyruvate potentiates the inotropic response to beta-adrenergic stimulation and to elevated extracellular calcium, since this may be of potential therapeutic value in the clinical setting of acute heart failure in order to circumvent deleterious effects on energy demand as can occur during catecholamine therapy. METHODS AND RESULTS: We investigated isometrically contracting isolated multicellular muscle preparations from terminal failing human hearts at 37 degrees C, pH 7.4, and a stimulation frequency of 1 Hz. At an extracellular calcium concentration of 1.25 mM, pyruvate (10 mM) alone increased developed force (F(dev)) from 9.0+/-2.3 to 21.1+/-4.3 mN/mm(2) (n=9, P

M3 - SCORING: Zeitschriftenaufsatz

VL - 53

SP - 116

EP - 123

JO - CARDIOVASC RES

JF - CARDIOVASC RES

SN - 0008-6363

IS - 1

M1 - 1

ER -