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Potentially inappropriate medication: Association between the use of antidepressant drugs and the subsequent risk for dementia

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Potentially inappropriate medication: Association between the use of antidepressant drugs and the subsequent risk for dementia. / Heser, Kathrin; Luck, Tobias; Röhr, Susanne; Wiese, Birgitt; Kaduszkiewicz, Hanna; Oey, Anke; Bickel, Horst; Mösch, Edelgard; Weyerer, Siegfried; Werle, Jochen; Brettschneider, Christian; König, Hans-Helmut; Fuchs, Angela; Pentzek, Michael; van den Bussche, Hendrik; Scherer, Martin; Maier, Wolfgang; Riedel-Heller, Steffi G; Wagner, Michael; AgeCoDe & AgeQualiDe study group.

in: J AFFECT DISORDERS, Jahrgang 226, 15.01.2018, S. 28-35.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Heser, K, Luck, T, Röhr, S, Wiese, B, Kaduszkiewicz, H, Oey, A, Bickel, H, Mösch, E, Weyerer, S, Werle, J, Brettschneider, C, König, H-H, Fuchs, A, Pentzek, M, van den Bussche, H, Scherer, M, Maier, W, Riedel-Heller, SG, Wagner, M & AgeCoDe & AgeQualiDe study group 2018, 'Potentially inappropriate medication: Association between the use of antidepressant drugs and the subsequent risk for dementia', J AFFECT DISORDERS, Jg. 226, S. 28-35. https://doi.org/10.1016/j.jad.2017.09.016

APA

Heser, K., Luck, T., Röhr, S., Wiese, B., Kaduszkiewicz, H., Oey, A., Bickel, H., Mösch, E., Weyerer, S., Werle, J., Brettschneider, C., König, H-H., Fuchs, A., Pentzek, M., van den Bussche, H., Scherer, M., Maier, W., Riedel-Heller, S. G., Wagner, M., & AgeCoDe & AgeQualiDe study group (2018). Potentially inappropriate medication: Association between the use of antidepressant drugs and the subsequent risk for dementia. J AFFECT DISORDERS, 226, 28-35. https://doi.org/10.1016/j.jad.2017.09.016

Vancouver

Heser K, Luck T, Röhr S, Wiese B, Kaduszkiewicz H, Oey A et al. Potentially inappropriate medication: Association between the use of antidepressant drugs and the subsequent risk for dementia. J AFFECT DISORDERS. 2018 Jan 15;226:28-35. https://doi.org/10.1016/j.jad.2017.09.016

Bibtex

@article{bd7d6d0a63f74f81aba85e9d93be227a,
title = "Potentially inappropriate medication: Association between the use of antidepressant drugs and the subsequent risk for dementia",
abstract = "BACKGROUND: Potentially inappropriate medication (PIM) is associated with an increased risk for detrimental health outcomes in elderly patients. Some antidepressant drugs are considered as PIM, but previous research on the association between antidepressants and subsequent dementia has been inconclusive. Therefore, we investigated whether the intake of antidepressants, particularly of those considered as PIM according to the Priscus list, would predict incident dementia.METHODS: We used data of a prospective cohort study of non-demented primary care patients (n = 3239, mean age = 79.62) to compute Cox proportional hazards models. The risk for subsequent dementia was estimated over eight follow-ups up to 12 years depending on antidepressant intake and covariates.RESULTS: The intake of antidepressants was associated with an increased risk for subsequent dementia (HR = 1.53, 95% CI: 1.16-2.02, p = .003; age-, sex-, education-adjusted). PIM antidepressants (HR = 1.49, 95% CI: 1.06-2.10, p = .021), but not other antidepressants (HR = 1.04, 95% CI: 0.66-1.66, p = .863), were associated with an increased risk for subsequent dementia (in age-, sex-, education-, and depressive symptoms adjusted models). Significant associations disappeared after global cognition at baseline was controlled for.LIMITATIONS: Methodological limitations such as selection biases and self-reported drug assessments might have influenced the results.CONCLUSIONS: Only antidepressants considered as PIM were associated with an increased subsequent dementia risk. Anticholinergic effects might explain this relationship. The association disappeared after the statistical control for global cognition at baseline. Nonetheless, physicians should avoid the prescription of PIM antidepressants in elderly patients whenever possible.",
keywords = "Journal Article",
author = "Kathrin Heser and Tobias Luck and Susanne R{\"o}hr and Birgitt Wiese and Hanna Kaduszkiewicz and Anke Oey and Horst Bickel and Edelgard M{\"o}sch and Siegfried Weyerer and Jochen Werle and Christian Brettschneider and Hans-Helmut K{\"o}nig and Angela Fuchs and Michael Pentzek and {van den Bussche}, Hendrik and Martin Scherer and Wolfgang Maier and Riedel-Heller, {Steffi G} and Michael Wagner and {AgeCoDe & AgeQualiDe study group}",
note = "Copyright {\textcopyright} 2017 Elsevier B.V. All rights reserved.",
year = "2018",
month = jan,
day = "15",
doi = "10.1016/j.jad.2017.09.016",
language = "English",
volume = "226",
pages = "28--35",
journal = "J AFFECT DISORDERS",
issn = "0165-0327",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Potentially inappropriate medication: Association between the use of antidepressant drugs and the subsequent risk for dementia

AU - Heser, Kathrin

AU - Luck, Tobias

AU - Röhr, Susanne

AU - Wiese, Birgitt

AU - Kaduszkiewicz, Hanna

AU - Oey, Anke

AU - Bickel, Horst

AU - Mösch, Edelgard

AU - Weyerer, Siegfried

AU - Werle, Jochen

AU - Brettschneider, Christian

AU - König, Hans-Helmut

AU - Fuchs, Angela

AU - Pentzek, Michael

AU - van den Bussche, Hendrik

AU - Scherer, Martin

AU - Maier, Wolfgang

AU - Riedel-Heller, Steffi G

AU - Wagner, Michael

AU - AgeCoDe & AgeQualiDe study group

N1 - Copyright © 2017 Elsevier B.V. All rights reserved.

PY - 2018/1/15

Y1 - 2018/1/15

N2 - BACKGROUND: Potentially inappropriate medication (PIM) is associated with an increased risk for detrimental health outcomes in elderly patients. Some antidepressant drugs are considered as PIM, but previous research on the association between antidepressants and subsequent dementia has been inconclusive. Therefore, we investigated whether the intake of antidepressants, particularly of those considered as PIM according to the Priscus list, would predict incident dementia.METHODS: We used data of a prospective cohort study of non-demented primary care patients (n = 3239, mean age = 79.62) to compute Cox proportional hazards models. The risk for subsequent dementia was estimated over eight follow-ups up to 12 years depending on antidepressant intake and covariates.RESULTS: The intake of antidepressants was associated with an increased risk for subsequent dementia (HR = 1.53, 95% CI: 1.16-2.02, p = .003; age-, sex-, education-adjusted). PIM antidepressants (HR = 1.49, 95% CI: 1.06-2.10, p = .021), but not other antidepressants (HR = 1.04, 95% CI: 0.66-1.66, p = .863), were associated with an increased risk for subsequent dementia (in age-, sex-, education-, and depressive symptoms adjusted models). Significant associations disappeared after global cognition at baseline was controlled for.LIMITATIONS: Methodological limitations such as selection biases and self-reported drug assessments might have influenced the results.CONCLUSIONS: Only antidepressants considered as PIM were associated with an increased subsequent dementia risk. Anticholinergic effects might explain this relationship. The association disappeared after the statistical control for global cognition at baseline. Nonetheless, physicians should avoid the prescription of PIM antidepressants in elderly patients whenever possible.

AB - BACKGROUND: Potentially inappropriate medication (PIM) is associated with an increased risk for detrimental health outcomes in elderly patients. Some antidepressant drugs are considered as PIM, but previous research on the association between antidepressants and subsequent dementia has been inconclusive. Therefore, we investigated whether the intake of antidepressants, particularly of those considered as PIM according to the Priscus list, would predict incident dementia.METHODS: We used data of a prospective cohort study of non-demented primary care patients (n = 3239, mean age = 79.62) to compute Cox proportional hazards models. The risk for subsequent dementia was estimated over eight follow-ups up to 12 years depending on antidepressant intake and covariates.RESULTS: The intake of antidepressants was associated with an increased risk for subsequent dementia (HR = 1.53, 95% CI: 1.16-2.02, p = .003; age-, sex-, education-adjusted). PIM antidepressants (HR = 1.49, 95% CI: 1.06-2.10, p = .021), but not other antidepressants (HR = 1.04, 95% CI: 0.66-1.66, p = .863), were associated with an increased risk for subsequent dementia (in age-, sex-, education-, and depressive symptoms adjusted models). Significant associations disappeared after global cognition at baseline was controlled for.LIMITATIONS: Methodological limitations such as selection biases and self-reported drug assessments might have influenced the results.CONCLUSIONS: Only antidepressants considered as PIM were associated with an increased subsequent dementia risk. Anticholinergic effects might explain this relationship. The association disappeared after the statistical control for global cognition at baseline. Nonetheless, physicians should avoid the prescription of PIM antidepressants in elderly patients whenever possible.

KW - Journal Article

U2 - 10.1016/j.jad.2017.09.016

DO - 10.1016/j.jad.2017.09.016

M3 - SCORING: Journal article

C2 - 28942203

VL - 226

SP - 28

EP - 35

JO - J AFFECT DISORDERS

JF - J AFFECT DISORDERS

SN - 0165-0327

ER -