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Population-Based External Validation of the Updated 2012 Partin Tables in Contemporary North American Prostate Cancer Patients

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Population-Based External Validation of the Updated 2012 Partin Tables in Contemporary North American Prostate Cancer Patients. / Leyh-Bannurah, Sami-Ramzi; Gazdovich, Stéphanie; Budäus, Lars; Zaffuto, Emanuele; Dell'Oglio, Paolo; Briganti, Alberto; Abdollah, Firas; Montorsi, Francesco; Schiffmann, Jonas; Menon, Mani; Shariat, Shahrokh F; Fisch, Margit; Chun, Felix; Graefen, Markus; Karakiewicz, Pierre I.

in: PROSTATE, Jahrgang 77, Nr. 1, 01.2017, S. 105-113.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Leyh-Bannurah, S-R, Gazdovich, S, Budäus, L, Zaffuto, E, Dell'Oglio, P, Briganti, A, Abdollah, F, Montorsi, F, Schiffmann, J, Menon, M, Shariat, SF, Fisch, M, Chun, F, Graefen, M & Karakiewicz, PI 2017, 'Population-Based External Validation of the Updated 2012 Partin Tables in Contemporary North American Prostate Cancer Patients', PROSTATE, Jg. 77, Nr. 1, S. 105-113. https://doi.org/10.1002/pros.23253

APA

Leyh-Bannurah, S-R., Gazdovich, S., Budäus, L., Zaffuto, E., Dell'Oglio, P., Briganti, A., Abdollah, F., Montorsi, F., Schiffmann, J., Menon, M., Shariat, S. F., Fisch, M., Chun, F., Graefen, M., & Karakiewicz, P. I. (2017). Population-Based External Validation of the Updated 2012 Partin Tables in Contemporary North American Prostate Cancer Patients. PROSTATE, 77(1), 105-113. https://doi.org/10.1002/pros.23253

Vancouver

Leyh-Bannurah S-R, Gazdovich S, Budäus L, Zaffuto E, Dell'Oglio P, Briganti A et al. Population-Based External Validation of the Updated 2012 Partin Tables in Contemporary North American Prostate Cancer Patients. PROSTATE. 2017 Jan;77(1):105-113. https://doi.org/10.1002/pros.23253

Bibtex

@article{0a2dd809293a48a0a13a430acbfc0e1a,
title = "Population-Based External Validation of the Updated 2012 Partin Tables in Contemporary North American Prostate Cancer Patients",
abstract = "OBJECTIVE: To externally validate the updated 2012 Partin Tables in contemporary North American patients treated with radical prostatectomy (RP) for localized prostate cancer (PCa) at community institutions.MATERIALS AND METHODS: We examined records of 25,254 patients treated with RP and pelvic lymph node dissection (PLND) between 2010 and 2013, within the surveillance, epidemiology, and end results database. The ROC derived AUC assessed discriminant properties of the updated 2012 Partin Tables of organ confined disease (OC), extracapsular extension (ECE), seminal vesical invasion (SVI), and lymph node invasion (LNI). Calibration plots focused on calibration between predicted and observed rates.RESULTS: Proportions of OC, ECE, SVI, and LNI at RP were 69.8%, 18.4%, 7.4%, and 4.4%, respectively. Accuracy for prediction of OC, ECE, SVI, and LNI was 70.4%, 59.9%, 72.9%, and 77.1%, respectively. In subgroup analyses in patients with nodal yield >10, accuracy for LNI prediction was 76.0%. Subgroup analyses in elderly patients and in African American patients revealed decreased accuracy for prediction of all four endpoints. Last but not least, SVI and LNI calibration plots showed excellent agreement, versus good agreement for OC (maximum underestimation of 10%) and poor agreement for ECE (maximum overestimation of 12%).CONCLUSION: Taken together, the updated 2012 Partin Tables can be unequivocally endorsed for prediction of OC, SVI, and LNI in community-based patients with localized PCa. Conversely, ECE predictions failed to reach the minimum accuracy requirements of 70%. Prostate 77:105-113, 2017. {\textcopyright} 2016 Wiley Periodicals, Inc.",
keywords = "Adult, Aged, Aged, 80 and over, Humans, Lymph Node Excision, Male, Middle Aged, Nomograms, North America, Population Surveillance, Prostatectomy, Prostatic Neoplasms, SEER Program, United States, Journal Article, Validation Studies",
author = "Sami-Ramzi Leyh-Bannurah and St{\'e}phanie Gazdovich and Lars Bud{\"a}us and Emanuele Zaffuto and Paolo Dell'Oglio and Alberto Briganti and Firas Abdollah and Francesco Montorsi and Jonas Schiffmann and Mani Menon and Shariat, {Shahrokh F} and Margit Fisch and Felix Chun and Markus Graefen and Karakiewicz, {Pierre I}",
note = "{\textcopyright} 2016 Wiley Periodicals, Inc.",
year = "2017",
month = jan,
doi = "10.1002/pros.23253",
language = "English",
volume = "77",
pages = "105--113",
journal = "PROSTATE",
issn = "0270-4137",
publisher = "Wiley-Liss Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Population-Based External Validation of the Updated 2012 Partin Tables in Contemporary North American Prostate Cancer Patients

AU - Leyh-Bannurah, Sami-Ramzi

AU - Gazdovich, Stéphanie

AU - Budäus, Lars

AU - Zaffuto, Emanuele

AU - Dell'Oglio, Paolo

AU - Briganti, Alberto

AU - Abdollah, Firas

AU - Montorsi, Francesco

AU - Schiffmann, Jonas

AU - Menon, Mani

AU - Shariat, Shahrokh F

AU - Fisch, Margit

AU - Chun, Felix

AU - Graefen, Markus

AU - Karakiewicz, Pierre I

N1 - © 2016 Wiley Periodicals, Inc.

PY - 2017/1

Y1 - 2017/1

N2 - OBJECTIVE: To externally validate the updated 2012 Partin Tables in contemporary North American patients treated with radical prostatectomy (RP) for localized prostate cancer (PCa) at community institutions.MATERIALS AND METHODS: We examined records of 25,254 patients treated with RP and pelvic lymph node dissection (PLND) between 2010 and 2013, within the surveillance, epidemiology, and end results database. The ROC derived AUC assessed discriminant properties of the updated 2012 Partin Tables of organ confined disease (OC), extracapsular extension (ECE), seminal vesical invasion (SVI), and lymph node invasion (LNI). Calibration plots focused on calibration between predicted and observed rates.RESULTS: Proportions of OC, ECE, SVI, and LNI at RP were 69.8%, 18.4%, 7.4%, and 4.4%, respectively. Accuracy for prediction of OC, ECE, SVI, and LNI was 70.4%, 59.9%, 72.9%, and 77.1%, respectively. In subgroup analyses in patients with nodal yield >10, accuracy for LNI prediction was 76.0%. Subgroup analyses in elderly patients and in African American patients revealed decreased accuracy for prediction of all four endpoints. Last but not least, SVI and LNI calibration plots showed excellent agreement, versus good agreement for OC (maximum underestimation of 10%) and poor agreement for ECE (maximum overestimation of 12%).CONCLUSION: Taken together, the updated 2012 Partin Tables can be unequivocally endorsed for prediction of OC, SVI, and LNI in community-based patients with localized PCa. Conversely, ECE predictions failed to reach the minimum accuracy requirements of 70%. Prostate 77:105-113, 2017. © 2016 Wiley Periodicals, Inc.

AB - OBJECTIVE: To externally validate the updated 2012 Partin Tables in contemporary North American patients treated with radical prostatectomy (RP) for localized prostate cancer (PCa) at community institutions.MATERIALS AND METHODS: We examined records of 25,254 patients treated with RP and pelvic lymph node dissection (PLND) between 2010 and 2013, within the surveillance, epidemiology, and end results database. The ROC derived AUC assessed discriminant properties of the updated 2012 Partin Tables of organ confined disease (OC), extracapsular extension (ECE), seminal vesical invasion (SVI), and lymph node invasion (LNI). Calibration plots focused on calibration between predicted and observed rates.RESULTS: Proportions of OC, ECE, SVI, and LNI at RP were 69.8%, 18.4%, 7.4%, and 4.4%, respectively. Accuracy for prediction of OC, ECE, SVI, and LNI was 70.4%, 59.9%, 72.9%, and 77.1%, respectively. In subgroup analyses in patients with nodal yield >10, accuracy for LNI prediction was 76.0%. Subgroup analyses in elderly patients and in African American patients revealed decreased accuracy for prediction of all four endpoints. Last but not least, SVI and LNI calibration plots showed excellent agreement, versus good agreement for OC (maximum underestimation of 10%) and poor agreement for ECE (maximum overestimation of 12%).CONCLUSION: Taken together, the updated 2012 Partin Tables can be unequivocally endorsed for prediction of OC, SVI, and LNI in community-based patients with localized PCa. Conversely, ECE predictions failed to reach the minimum accuracy requirements of 70%. Prostate 77:105-113, 2017. © 2016 Wiley Periodicals, Inc.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Humans

KW - Lymph Node Excision

KW - Male

KW - Middle Aged

KW - Nomograms

KW - North America

KW - Population Surveillance

KW - Prostatectomy

KW - Prostatic Neoplasms

KW - SEER Program

KW - United States

KW - Journal Article

KW - Validation Studies

U2 - 10.1002/pros.23253

DO - 10.1002/pros.23253

M3 - SCORING: Journal article

C2 - 27683103

VL - 77

SP - 105

EP - 113

JO - PROSTATE

JF - PROSTATE

SN - 0270-4137

IS - 1

ER -