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Popeye-domain-containing proteins modulate the voltage-gated cardiac sodium channel Nav1.5

Standard

Popeye-domain-containing proteins modulate the voltage-gated cardiac sodium channel Nav1.5. / Rinné, Susanne; Kiper, Aytug K.; Jacob, Ralf; Ortiz-Bonnin, Beatriz; Schindler, Roland F.R.; Fischer, Sabine; Komadowski, Marlene; deMartino, Emilia; Schäfer, Martin K.-H.; Cornelius, Tamina; Fabritz, Larissa; Helker, Christian S.M.; Brand, Thomas; Decher, Niels.

in: ISCIENCE, Jahrgang 27, Nr. 5, 17.05.2024, S. 109696.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Rinné, S, Kiper, AK, Jacob, R, Ortiz-Bonnin, B, Schindler, RFR, Fischer, S, Komadowski, M, deMartino, E, Schäfer, MK-H, Cornelius, T, Fabritz, L, Helker, CSM, Brand, T & Decher, N 2024, 'Popeye-domain-containing proteins modulate the voltage-gated cardiac sodium channel Nav1.5', ISCIENCE, Jg. 27, Nr. 5, S. 109696. https://doi.org/10.1016/j.isci.2024.109696

APA

Rinné, S., Kiper, A. K., Jacob, R., Ortiz-Bonnin, B., Schindler, R. F. R., Fischer, S., Komadowski, M., deMartino, E., Schäfer, M. K-H., Cornelius, T., Fabritz, L., Helker, C. S. M., Brand, T., & Decher, N. (2024). Popeye-domain-containing proteins modulate the voltage-gated cardiac sodium channel Nav1.5. ISCIENCE, 27(5), 109696. https://doi.org/10.1016/j.isci.2024.109696

Vancouver

Rinné S, Kiper AK, Jacob R, Ortiz-Bonnin B, Schindler RFR, Fischer S et al. Popeye-domain-containing proteins modulate the voltage-gated cardiac sodium channel Nav1.5. ISCIENCE. 2024 Mai 17;27(5):109696. https://doi.org/10.1016/j.isci.2024.109696

Bibtex

@article{0cbcd1b1d4ed4a78812228238f632aad,
title = "Popeye-domain-containing proteins modulate the voltage-gated cardiac sodium channel Nav1.5",
abstract = "Popeye domain containing (POPDC) proteins are predominantly expressed in the heart and skeletal muscle, modulating the K2P potassium channel TREK-1 in a cAMP-dependent manner. POPDC1 and POPDC2 variants cause cardiac conduction disorders with or without muscular dystrophy. Searching for POPDC2-modulated ion channels using a functional co-expression screen in Xenopus oocytes, we found POPDC proteins to modulate the cardiac sodium channel Nav1.5. POPDC proteins downregulate Nav1.5 currents in a cAMP-dependent manner by reducing the surface expression of the channel. POPDC2 and Nav1.5 are both expressed in different regions of the murine heart and consistently POPDC2 co-immunoprecipitates with Nav1.5 from native cardiac tissue. Strikingly, the knock-down of popdc2 in embryonic zebrafish caused an increased upstroke velocity and overshoot of cardiac action potentials. The POPDC modulation of Nav1.5 provides a new mechanism to regulate cardiac sodium channel densities under sympathetic stimulation, which is likely to have a functional impact on cardiac physiology and inherited arrhythmias.",
keywords = "ion channel, Nav1.5, POPDC, Popeye-domain-containing proteins, sodium channel",
author = "Susanne Rinn{\'e} and Kiper, {Aytug K.} and Ralf Jacob and Beatriz Ortiz-Bonnin and Schindler, {Roland F.R.} and Sabine Fischer and Marlene Komadowski and Emilia deMartino and Sch{\"a}fer, {Martin K.-H.} and Tamina Cornelius and Larissa Fabritz and Helker, {Christian S.M.} and Thomas Brand and Niels Decher",
year = "2024",
month = may,
day = "17",
doi = "10.1016/j.isci.2024.109696",
language = "English",
volume = "27",
pages = "109696",
journal = "ISCIENCE",
issn = "2589-0042",
publisher = "Elsevier Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - Popeye-domain-containing proteins modulate the voltage-gated cardiac sodium channel Nav1.5

AU - Rinné, Susanne

AU - Kiper, Aytug K.

AU - Jacob, Ralf

AU - Ortiz-Bonnin, Beatriz

AU - Schindler, Roland F.R.

AU - Fischer, Sabine

AU - Komadowski, Marlene

AU - deMartino, Emilia

AU - Schäfer, Martin K.-H.

AU - Cornelius, Tamina

AU - Fabritz, Larissa

AU - Helker, Christian S.M.

AU - Brand, Thomas

AU - Decher, Niels

PY - 2024/5/17

Y1 - 2024/5/17

N2 - Popeye domain containing (POPDC) proteins are predominantly expressed in the heart and skeletal muscle, modulating the K2P potassium channel TREK-1 in a cAMP-dependent manner. POPDC1 and POPDC2 variants cause cardiac conduction disorders with or without muscular dystrophy. Searching for POPDC2-modulated ion channels using a functional co-expression screen in Xenopus oocytes, we found POPDC proteins to modulate the cardiac sodium channel Nav1.5. POPDC proteins downregulate Nav1.5 currents in a cAMP-dependent manner by reducing the surface expression of the channel. POPDC2 and Nav1.5 are both expressed in different regions of the murine heart and consistently POPDC2 co-immunoprecipitates with Nav1.5 from native cardiac tissue. Strikingly, the knock-down of popdc2 in embryonic zebrafish caused an increased upstroke velocity and overshoot of cardiac action potentials. The POPDC modulation of Nav1.5 provides a new mechanism to regulate cardiac sodium channel densities under sympathetic stimulation, which is likely to have a functional impact on cardiac physiology and inherited arrhythmias.

AB - Popeye domain containing (POPDC) proteins are predominantly expressed in the heart and skeletal muscle, modulating the K2P potassium channel TREK-1 in a cAMP-dependent manner. POPDC1 and POPDC2 variants cause cardiac conduction disorders with or without muscular dystrophy. Searching for POPDC2-modulated ion channels using a functional co-expression screen in Xenopus oocytes, we found POPDC proteins to modulate the cardiac sodium channel Nav1.5. POPDC proteins downregulate Nav1.5 currents in a cAMP-dependent manner by reducing the surface expression of the channel. POPDC2 and Nav1.5 are both expressed in different regions of the murine heart and consistently POPDC2 co-immunoprecipitates with Nav1.5 from native cardiac tissue. Strikingly, the knock-down of popdc2 in embryonic zebrafish caused an increased upstroke velocity and overshoot of cardiac action potentials. The POPDC modulation of Nav1.5 provides a new mechanism to regulate cardiac sodium channel densities under sympathetic stimulation, which is likely to have a functional impact on cardiac physiology and inherited arrhythmias.

KW - ion channel

KW - Nav1.5

KW - POPDC

KW - Popeye-domain-containing proteins

KW - sodium channel

U2 - 10.1016/j.isci.2024.109696

DO - 10.1016/j.isci.2024.109696

M3 - SCORING: Journal article

C2 - 38689644

VL - 27

SP - 109696

JO - ISCIENCE

JF - ISCIENCE

SN - 2589-0042

IS - 5

ER -