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Polysaccharide intercellular adhesin or protein factors in biofilm accumulation of Staphylococcus epidermidis and Staphylococcus aureus isolated from prosthetic hip and knee joint infections.

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Polysaccharide intercellular adhesin or protein factors in biofilm accumulation of Staphylococcus epidermidis and Staphylococcus aureus isolated from prosthetic hip and knee joint infections. / Rohde, Holger; Burandt, Eike Christian; Siemssen, Nicolaus; Frommelt, Lars; Burdelski, Christoph; Wurster, Sabine; Scherpe, Stefanie; Davies, Angharad P; Harris, Llinos G; Horstkotte, Matthias A; Knobloch, Johannes K-M; Ragunath, Chandran; Kaplan, Jeffrey B; Mack, Dietrich.

in: BIOMATERIALS, Jahrgang 28, Nr. 9, 9, 2007, S. 1711-1720.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Rohde, H, Burandt, EC, Siemssen, N, Frommelt, L, Burdelski, C, Wurster, S, Scherpe, S, Davies, AP, Harris, LG, Horstkotte, MA, Knobloch, JK-M, Ragunath, C, Kaplan, JB & Mack, D 2007, 'Polysaccharide intercellular adhesin or protein factors in biofilm accumulation of Staphylococcus epidermidis and Staphylococcus aureus isolated from prosthetic hip and knee joint infections.', BIOMATERIALS, Jg. 28, Nr. 9, 9, S. 1711-1720. https://doi.org/10.1016/j.biomaterials.2006.11.046

APA

Rohde, H., Burandt, E. C., Siemssen, N., Frommelt, L., Burdelski, C., Wurster, S., Scherpe, S., Davies, A. P., Harris, L. G., Horstkotte, M. A., Knobloch, J. K-M., Ragunath, C., Kaplan, J. B., & Mack, D. (2007). Polysaccharide intercellular adhesin or protein factors in biofilm accumulation of Staphylococcus epidermidis and Staphylococcus aureus isolated from prosthetic hip and knee joint infections. BIOMATERIALS, 28(9), 1711-1720. [9]. https://doi.org/10.1016/j.biomaterials.2006.11.046

Vancouver

Rohde H, Burandt EC, Siemssen N, Frommelt L, Burdelski C, Wurster S et al. Polysaccharide intercellular adhesin or protein factors in biofilm accumulation of Staphylococcus epidermidis and Staphylococcus aureus isolated from prosthetic hip and knee joint infections. BIOMATERIALS. 2007;28(9):1711-1720. 9. https://doi.org/10.1016/j.biomaterials.2006.11.046

Bibtex

@article{0e6bd69e141a4c86a09b16172222e587,
title = "Polysaccharide intercellular adhesin or protein factors in biofilm accumulation of Staphylococcus epidermidis and Staphylococcus aureus isolated from prosthetic hip and knee joint infections.",
abstract = "Nosocomial staphylococcal foreign-body infections related to biofilm formation are a serious threat, demanding new therapeutic and preventive strategies. As the use of biofilm-associated factors as vaccines is critically restricted by their prevalence in natural staphylococcal populations we studied the distribution of genes involved in biofilm formation, the biofilm phenotype and production of polysaccharide intercellular adhesin (PIA) in clonally independent Staphylococcus aureus and Staphylococcus epidermidis strains isolated from prosthetic joint infections after total hip or total knee arthroplasty. Biofilm formation was detected in all S. aureus and 69.2% of S. epidermidis strains. Importantly, 27% of biofilm-positive S. epidermidis produced PIA-independent biofilms, in part mediated by the accumulation associated protein (Aap). Protein-dependent biofilms were exclusively found in S. epidermidis strains from total hip arthroplasty (THA). In S. aureus PIA and proteins act cooperatively in biofilm formation regardless of the infection site. PIA and protein factors like Aap are of differential importance for the pathogenesis of S. epidermidis in prosthetic joint infections (PJI) after THA and total knee arthroplasty (TKA), implicating that icaADBC cannot serve as a general virulence marker in this species. In S. aureus biofilm formation proteins are of overall importance and future work should focus on the identification of functionally active molecules.",
author = "Holger Rohde and Burandt, {Eike Christian} and Nicolaus Siemssen and Lars Frommelt and Christoph Burdelski and Sabine Wurster and Stefanie Scherpe and Davies, {Angharad P} and Harris, {Llinos G} and Horstkotte, {Matthias A} and Knobloch, {Johannes K-M} and Chandran Ragunath and Kaplan, {Jeffrey B} and Dietrich Mack",
year = "2007",
doi = "10.1016/j.biomaterials.2006.11.046",
language = "Deutsch",
volume = "28",
pages = "1711--1720",
journal = "BIOMATERIALS",
issn = "0142-9612",
publisher = "Elsevier BV",
number = "9",

}

RIS

TY - JOUR

T1 - Polysaccharide intercellular adhesin or protein factors in biofilm accumulation of Staphylococcus epidermidis and Staphylococcus aureus isolated from prosthetic hip and knee joint infections.

AU - Rohde, Holger

AU - Burandt, Eike Christian

AU - Siemssen, Nicolaus

AU - Frommelt, Lars

AU - Burdelski, Christoph

AU - Wurster, Sabine

AU - Scherpe, Stefanie

AU - Davies, Angharad P

AU - Harris, Llinos G

AU - Horstkotte, Matthias A

AU - Knobloch, Johannes K-M

AU - Ragunath, Chandran

AU - Kaplan, Jeffrey B

AU - Mack, Dietrich

PY - 2007

Y1 - 2007

N2 - Nosocomial staphylococcal foreign-body infections related to biofilm formation are a serious threat, demanding new therapeutic and preventive strategies. As the use of biofilm-associated factors as vaccines is critically restricted by their prevalence in natural staphylococcal populations we studied the distribution of genes involved in biofilm formation, the biofilm phenotype and production of polysaccharide intercellular adhesin (PIA) in clonally independent Staphylococcus aureus and Staphylococcus epidermidis strains isolated from prosthetic joint infections after total hip or total knee arthroplasty. Biofilm formation was detected in all S. aureus and 69.2% of S. epidermidis strains. Importantly, 27% of biofilm-positive S. epidermidis produced PIA-independent biofilms, in part mediated by the accumulation associated protein (Aap). Protein-dependent biofilms were exclusively found in S. epidermidis strains from total hip arthroplasty (THA). In S. aureus PIA and proteins act cooperatively in biofilm formation regardless of the infection site. PIA and protein factors like Aap are of differential importance for the pathogenesis of S. epidermidis in prosthetic joint infections (PJI) after THA and total knee arthroplasty (TKA), implicating that icaADBC cannot serve as a general virulence marker in this species. In S. aureus biofilm formation proteins are of overall importance and future work should focus on the identification of functionally active molecules.

AB - Nosocomial staphylococcal foreign-body infections related to biofilm formation are a serious threat, demanding new therapeutic and preventive strategies. As the use of biofilm-associated factors as vaccines is critically restricted by their prevalence in natural staphylococcal populations we studied the distribution of genes involved in biofilm formation, the biofilm phenotype and production of polysaccharide intercellular adhesin (PIA) in clonally independent Staphylococcus aureus and Staphylococcus epidermidis strains isolated from prosthetic joint infections after total hip or total knee arthroplasty. Biofilm formation was detected in all S. aureus and 69.2% of S. epidermidis strains. Importantly, 27% of biofilm-positive S. epidermidis produced PIA-independent biofilms, in part mediated by the accumulation associated protein (Aap). Protein-dependent biofilms were exclusively found in S. epidermidis strains from total hip arthroplasty (THA). In S. aureus PIA and proteins act cooperatively in biofilm formation regardless of the infection site. PIA and protein factors like Aap are of differential importance for the pathogenesis of S. epidermidis in prosthetic joint infections (PJI) after THA and total knee arthroplasty (TKA), implicating that icaADBC cannot serve as a general virulence marker in this species. In S. aureus biofilm formation proteins are of overall importance and future work should focus on the identification of functionally active molecules.

U2 - 10.1016/j.biomaterials.2006.11.046

DO - 10.1016/j.biomaterials.2006.11.046

M3 - SCORING: Zeitschriftenaufsatz

VL - 28

SP - 1711

EP - 1720

JO - BIOMATERIALS

JF - BIOMATERIALS

SN - 0142-9612

IS - 9

M1 - 9

ER -