Polyketides metabolites from the marine sediment-derived fungus Thermomyces lanuginosus Tsikl. KMM 4681
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Polyketides metabolites from the marine sediment-derived fungus Thermomyces lanuginosus Tsikl. KMM 4681. / Sobolevskaya, Maria P.; Berdyshev, Dmitrii V.; Zhuravleva, Olesya I.; Denisenko, Vladimir A.; Dyshlovoy, Sergey A.; von Amsberg, Gunhild; Khudyakova, Yuliya V.; Kirichuk, Natalya N.; Afiyatullov, Shamil Sh.
in: PHYTOCHEM LETT, Jahrgang 41, 02.2021, S. 114-118.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Polyketides metabolites from the marine sediment-derived fungus Thermomyces lanuginosus Tsikl. KMM 4681
AU - Sobolevskaya, Maria P.
AU - Berdyshev, Dmitrii V.
AU - Zhuravleva, Olesya I.
AU - Denisenko, Vladimir A.
AU - Dyshlovoy, Sergey A.
AU - von Amsberg, Gunhild
AU - Khudyakova, Yuliya V.
AU - Kirichuk, Natalya N.
AU - Afiyatullov, Shamil Sh
N1 - Funding Information: We thank the Collective Facilities Center “The Far Eastern Center for Structural Molecular Research (NMR/MS) PIBOC FEB RAS” (Dr. Natalya. Yu. Kim, Dr. Roman.S. Popov and Dr. Valery. P. Glazunov) for recording MS, CD, UV, and IR data. The study was carried out using the Collective Facilities Center “Collection of Marine Microorganisms PIBOC FEB RAS”. The study was supported by Russian Foundation for Basic Research (grant № 19-53-54002 ). Publisher Copyright: © 2020 Phytochemical Society of Europe Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2021/2
Y1 - 2021/2
N2 - New 1,3,6-trihydroxy-7-(dihydroxypropyl)-anthraquinone (1) and 6-(3′-hydroxybutan-2′-yl)-3,5-dimethyltetrahydro-2H-pyran-2-one (2), along with three previously known compounds, 1,3-dihydroxy-6-hydroxymethyl-7-methoxyanthraquinone (3), 1,3-dihydroxy-6-methyl-7-methoxyanthraquinone (4) and biphenyl-2,2′-diyl-diacetate (5) were isolated from the lipophilic extract of the marine sediment-derived fungus Thermomyces lanuginosus KMM 4681. The structures of the isolated compounds were established based on spectroscopic data. The absolute configurations of the stereocentres of 1 were determined using the time-dependent density functional theory (TD-DFT) calculation of ECD spectra. The effects of 1-4 on viability and colony formation of drug-resistant prostate cancer 22Rv1 and human PNT-2 cells were examined.
AB - New 1,3,6-trihydroxy-7-(dihydroxypropyl)-anthraquinone (1) and 6-(3′-hydroxybutan-2′-yl)-3,5-dimethyltetrahydro-2H-pyran-2-one (2), along with three previously known compounds, 1,3-dihydroxy-6-hydroxymethyl-7-methoxyanthraquinone (3), 1,3-dihydroxy-6-methyl-7-methoxyanthraquinone (4) and biphenyl-2,2′-diyl-diacetate (5) were isolated from the lipophilic extract of the marine sediment-derived fungus Thermomyces lanuginosus KMM 4681. The structures of the isolated compounds were established based on spectroscopic data. The absolute configurations of the stereocentres of 1 were determined using the time-dependent density functional theory (TD-DFT) calculation of ECD spectra. The effects of 1-4 on viability and colony formation of drug-resistant prostate cancer 22Rv1 and human PNT-2 cells were examined.
KW - Acetonide
KW - Anthraquinone
KW - Derivative
KW - HPLC
KW - NMR
KW - Prostate cancer
KW - Spectroscopy
KW - Thermomyces lanuginosus
KW - Time-dependent density functional theory (TD-DFT)
UR - http://www.scopus.com/inward/record.url?scp=85097448098&partnerID=8YFLogxK
U2 - 10.1016/j.phytol.2020.11.014
DO - 10.1016/j.phytol.2020.11.014
M3 - SCORING: Journal article
AN - SCOPUS:85097448098
VL - 41
SP - 114
EP - 118
JO - PHYTOCHEM LETT
JF - PHYTOCHEM LETT
SN - 1874-3900
ER -