Podocyte polarity signalling
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Podocyte polarity signalling. / Simons, Matias; Hartleben, Björn; Huber, Tobias B.
in: CURR OPIN NEPHROL HY, Jahrgang 18, Nr. 4, 07.2009, S. 324-30.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Podocyte polarity signalling
AU - Simons, Matias
AU - Hartleben, Björn
AU - Huber, Tobias B
PY - 2009/7
Y1 - 2009/7
N2 - PURPOSE OF REVIEW: The glomerular filtration barrier is a unique structure characterized by a specialized three-dimensional framework of podocytes. This review is aimed at describing the latest advances made in the understanding of polarity signalling pathways regulating the formation and the maintenance of the complex podocyte architecture.RECENT FINDINGS: Podocytes are composed of a large cell body that extends primary and secondary processes. An apicobasal polarity axis allows for podocyte orientation between the urinary space and the glomerular basement membrane. Recent studies document that conserved polarity protein complexes such as the partitioning defective 3 (Par3), partitioning defective 6 (Par6) and atypical protein kinase C (aPKC) complex are essential regulators of podocyte morphology. Glomerular development, slit diaphragm targeting and apicobasolateral distribution of molecules seem to be tightly regulated by these polarity signalling pathways.SUMMARY: Accumulating evidence indicates that conserved polarity protein complexes are essential for normal podocyte morphology and differentiation. The diseased podocyte, which typically presents with foot process effacement, might require these molecular guideposts when recovering from stress and when restoring normal podocyte morphology.
AB - PURPOSE OF REVIEW: The glomerular filtration barrier is a unique structure characterized by a specialized three-dimensional framework of podocytes. This review is aimed at describing the latest advances made in the understanding of polarity signalling pathways regulating the formation and the maintenance of the complex podocyte architecture.RECENT FINDINGS: Podocytes are composed of a large cell body that extends primary and secondary processes. An apicobasal polarity axis allows for podocyte orientation between the urinary space and the glomerular basement membrane. Recent studies document that conserved polarity protein complexes such as the partitioning defective 3 (Par3), partitioning defective 6 (Par6) and atypical protein kinase C (aPKC) complex are essential regulators of podocyte morphology. Glomerular development, slit diaphragm targeting and apicobasolateral distribution of molecules seem to be tightly regulated by these polarity signalling pathways.SUMMARY: Accumulating evidence indicates that conserved polarity protein complexes are essential for normal podocyte morphology and differentiation. The diseased podocyte, which typically presents with foot process effacement, might require these molecular guideposts when recovering from stress and when restoring normal podocyte morphology.
KW - Adaptor Proteins, Signal Transducing
KW - Animals
KW - Cell Cycle Proteins
KW - Cell Differentiation
KW - Cell Polarity
KW - Cell Shape
KW - Humans
KW - Kidney Glomerulus
KW - Membrane Proteins
KW - Morphogenesis
KW - Podocytes
KW - Protein Kinase C
KW - Signal Transduction
KW - Transforming Growth Factor beta
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
KW - Review
U2 - 10.1097/MNH.0b013e32832e316d
DO - 10.1097/MNH.0b013e32832e316d
M3 - SCORING: Review article
C2 - 19542980
VL - 18
SP - 324
EP - 330
IS - 4
ER -
