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Platelet-mediated shedding of NKG2D ligands impairs NK cell immune-surveillance of tumor cells

Standard

Platelet-mediated shedding of NKG2D ligands impairs NK cell immune-surveillance of tumor cells. / Maurer, Stefanie; Kropp, Korbinian Nepomuk; Klein, Gerd; Steinle, Alexander; Haen, Sebastian P; Walz, Juliane S; Hinterleitner, Clemens; Märklin, Melanie; Kopp, Hans-Georg; Salih, Helmut Rainer.

in: ONCOIMMUNOLOGY, Jahrgang 7, Nr. 2, 2018, S. e1364827.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Maurer, S, Kropp, KN, Klein, G, Steinle, A, Haen, SP, Walz, JS, Hinterleitner, C, Märklin, M, Kopp, H-G & Salih, HR 2018, 'Platelet-mediated shedding of NKG2D ligands impairs NK cell immune-surveillance of tumor cells', ONCOIMMUNOLOGY, Jg. 7, Nr. 2, S. e1364827. https://doi.org/10.1080/2162402X.2017.1364827

APA

Maurer, S., Kropp, K. N., Klein, G., Steinle, A., Haen, S. P., Walz, J. S., Hinterleitner, C., Märklin, M., Kopp, H-G., & Salih, H. R. (2018). Platelet-mediated shedding of NKG2D ligands impairs NK cell immune-surveillance of tumor cells. ONCOIMMUNOLOGY, 7(2), e1364827. https://doi.org/10.1080/2162402X.2017.1364827

Vancouver

Maurer S, Kropp KN, Klein G, Steinle A, Haen SP, Walz JS et al. Platelet-mediated shedding of NKG2D ligands impairs NK cell immune-surveillance of tumor cells. ONCOIMMUNOLOGY. 2018;7(2):e1364827. https://doi.org/10.1080/2162402X.2017.1364827

Bibtex

@article{6b20bd0848d94597945434988499f4d4,
title = "Platelet-mediated shedding of NKG2D ligands impairs NK cell immune-surveillance of tumor cells",
abstract = "Platelets promote metastasis, among others by coating cancer cells traveling through the blood, which results in protection from NK cell immune-surveillance. The underlying mechanisms, however, remain to be fully elucidated. Here we report that platelet-coating reduces surface expression of NKG2D ligands, in particular MICA and MICB, on tumor cells, which was mirrored by enhanced release of their soluble ectodomains. Similar results were obtained upon exposure of tumor cells to platelet-releasate and can be attributed to the sheddases ADAM10 and ADAM17 that are detectable on the platelet surface and in releasate following activation and at higher levels on platelets of patients with metastasized lung cancer compared with healthy controls. Platelet-mediated NKG2DL-shedding in turn resulted in impaired {"}induced self{"} recognition by NK cells as revealed by diminished NKG2D-dependent lysis of tumor cells. Our results indicate that platelet-mediated NKG2DL-shedding may be involved in immune-evasion of (metastasizing) tumor cells from NK cell reactivity.",
author = "Stefanie Maurer and Kropp, {Korbinian Nepomuk} and Gerd Klein and Alexander Steinle and Haen, {Sebastian P} and Walz, {Juliane S} and Clemens Hinterleitner and Melanie M{\"a}rklin and Hans-Georg Kopp and Salih, {Helmut Rainer}",
year = "2018",
doi = "10.1080/2162402X.2017.1364827",
language = "English",
volume = "7",
pages = "e1364827",
journal = "ONCOIMMUNOLOGY",
issn = "2162-402X",
publisher = "Taylor & Francis",
number = "2",

}

RIS

TY - JOUR

T1 - Platelet-mediated shedding of NKG2D ligands impairs NK cell immune-surveillance of tumor cells

AU - Maurer, Stefanie

AU - Kropp, Korbinian Nepomuk

AU - Klein, Gerd

AU - Steinle, Alexander

AU - Haen, Sebastian P

AU - Walz, Juliane S

AU - Hinterleitner, Clemens

AU - Märklin, Melanie

AU - Kopp, Hans-Georg

AU - Salih, Helmut Rainer

PY - 2018

Y1 - 2018

N2 - Platelets promote metastasis, among others by coating cancer cells traveling through the blood, which results in protection from NK cell immune-surveillance. The underlying mechanisms, however, remain to be fully elucidated. Here we report that platelet-coating reduces surface expression of NKG2D ligands, in particular MICA and MICB, on tumor cells, which was mirrored by enhanced release of their soluble ectodomains. Similar results were obtained upon exposure of tumor cells to platelet-releasate and can be attributed to the sheddases ADAM10 and ADAM17 that are detectable on the platelet surface and in releasate following activation and at higher levels on platelets of patients with metastasized lung cancer compared with healthy controls. Platelet-mediated NKG2DL-shedding in turn resulted in impaired "induced self" recognition by NK cells as revealed by diminished NKG2D-dependent lysis of tumor cells. Our results indicate that platelet-mediated NKG2DL-shedding may be involved in immune-evasion of (metastasizing) tumor cells from NK cell reactivity.

AB - Platelets promote metastasis, among others by coating cancer cells traveling through the blood, which results in protection from NK cell immune-surveillance. The underlying mechanisms, however, remain to be fully elucidated. Here we report that platelet-coating reduces surface expression of NKG2D ligands, in particular MICA and MICB, on tumor cells, which was mirrored by enhanced release of their soluble ectodomains. Similar results were obtained upon exposure of tumor cells to platelet-releasate and can be attributed to the sheddases ADAM10 and ADAM17 that are detectable on the platelet surface and in releasate following activation and at higher levels on platelets of patients with metastasized lung cancer compared with healthy controls. Platelet-mediated NKG2DL-shedding in turn resulted in impaired "induced self" recognition by NK cells as revealed by diminished NKG2D-dependent lysis of tumor cells. Our results indicate that platelet-mediated NKG2DL-shedding may be involved in immune-evasion of (metastasizing) tumor cells from NK cell reactivity.

U2 - 10.1080/2162402X.2017.1364827

DO - 10.1080/2162402X.2017.1364827

M3 - SCORING: Journal article

C2 - 29308299

VL - 7

SP - e1364827

JO - ONCOIMMUNOLOGY

JF - ONCOIMMUNOLOGY

SN - 2162-402X

IS - 2

ER -