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Plasma ubiquinol-10 as a marker for disease: is the assay worthwhile?

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Plasma ubiquinol-10 as a marker for disease: is the assay worthwhile? / Kontush, A; Schippling, Sven; Spranger, T; Beisiegel, U.

in: BIOFACTORS, Jahrgang 9, Nr. 2-4, 2-4, 1999, S. 225-229.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kontush, A, Schippling, S, Spranger, T & Beisiegel, U 1999, 'Plasma ubiquinol-10 as a marker for disease: is the assay worthwhile?', BIOFACTORS, Jg. 9, Nr. 2-4, 2-4, S. 225-229. <http://www.ncbi.nlm.nih.gov/pubmed/10416034?dopt=Citation>

APA

Kontush, A., Schippling, S., Spranger, T., & Beisiegel, U. (1999). Plasma ubiquinol-10 as a marker for disease: is the assay worthwhile? BIOFACTORS, 9(2-4), 225-229. [2-4]. http://www.ncbi.nlm.nih.gov/pubmed/10416034?dopt=Citation

Vancouver

Kontush A, Schippling S, Spranger T, Beisiegel U. Plasma ubiquinol-10 as a marker for disease: is the assay worthwhile? BIOFACTORS. 1999;9(2-4):225-229. 2-4.

Bibtex

@article{df3a84fa5a914ff8bbcd48ec752c7a3b,
title = "Plasma ubiquinol-10 as a marker for disease: is the assay worthwhile?",
abstract = "Ubiquinol-10 and ubiquinone-10 were measured in plasma of patients with several pathologies known to be associated with increased oxidative stress. Plasma ubiquinol-10, expressed as a percentage of total ubiquinol-10 + ubiquinone-10, was found to be significantly lower in hyperlipidaemic patients and in patients with liver diseases than in age-matched control subjects. In contrast, no decrease in ubiquinol-10 was detected in plasma of patients with coronary heart disease and Alzheimer's disease. Except for ubiquinol-10, no other lipophilic antioxidant was found to be decreased in patients with liver diseases. These data suggest that the level of ubiquinol-10 in human plasma may serve as a marker for liver dysfunction, reflecting its diminished reduction by the liver rather than increased consumption by oxidants.",
author = "A Kontush and Sven Schippling and T Spranger and U Beisiegel",
year = "1999",
language = "Deutsch",
volume = "9",
pages = "225--229",
journal = "BIOFACTORS",
issn = "0951-6433",
publisher = "Wiley-Blackwell",
number = "2-4",

}

RIS

TY - JOUR

T1 - Plasma ubiquinol-10 as a marker for disease: is the assay worthwhile?

AU - Kontush, A

AU - Schippling, Sven

AU - Spranger, T

AU - Beisiegel, U

PY - 1999

Y1 - 1999

N2 - Ubiquinol-10 and ubiquinone-10 were measured in plasma of patients with several pathologies known to be associated with increased oxidative stress. Plasma ubiquinol-10, expressed as a percentage of total ubiquinol-10 + ubiquinone-10, was found to be significantly lower in hyperlipidaemic patients and in patients with liver diseases than in age-matched control subjects. In contrast, no decrease in ubiquinol-10 was detected in plasma of patients with coronary heart disease and Alzheimer's disease. Except for ubiquinol-10, no other lipophilic antioxidant was found to be decreased in patients with liver diseases. These data suggest that the level of ubiquinol-10 in human plasma may serve as a marker for liver dysfunction, reflecting its diminished reduction by the liver rather than increased consumption by oxidants.

AB - Ubiquinol-10 and ubiquinone-10 were measured in plasma of patients with several pathologies known to be associated with increased oxidative stress. Plasma ubiquinol-10, expressed as a percentage of total ubiquinol-10 + ubiquinone-10, was found to be significantly lower in hyperlipidaemic patients and in patients with liver diseases than in age-matched control subjects. In contrast, no decrease in ubiquinol-10 was detected in plasma of patients with coronary heart disease and Alzheimer's disease. Except for ubiquinol-10, no other lipophilic antioxidant was found to be decreased in patients with liver diseases. These data suggest that the level of ubiquinol-10 in human plasma may serve as a marker for liver dysfunction, reflecting its diminished reduction by the liver rather than increased consumption by oxidants.

M3 - SCORING: Zeitschriftenaufsatz

VL - 9

SP - 225

EP - 229

JO - BIOFACTORS

JF - BIOFACTORS

SN - 0951-6433

IS - 2-4

M1 - 2-4

ER -