Plasma oxidized low-density lipoprotein, a strong predictor for acute coronary heart disease events in apparently healthy, middle-aged men from the general population

TY - JOUR

T1 - Plasma oxidized low-density lipoprotein, a strong predictor for acute coronary heart disease events in apparently healthy, middle-aged men from the general population

AU - Meisinger, Christa

AU - Baumert, Jens

AU - Khuseyinova, Natalie

AU - Loewel, Hannelore

AU - Koenig, Wolfgang

PY - 2005/8/2

Y1 - 2005/8/2

N2 - BACKGROUND: Oxidized LDL (oxLDL) is thought to play a key role in the inflammatory response in the arterial vessel wall.METHODS AND RESULTS: In a prospective, nested, case-control study, the association between plasma oxLDL and risk of an acute coronary heart disease (CHD) event was investigated in men without prevalent CHD or diabetes mellitus at baseline. Subjects came from 2 population-based MONICA/KORA Augsburg surveys conducted in the years 1989-1990 and 1994-1995 with follow-up in 1998 (mean+/-SD follow-up time, 5.6+/-2.6 years). OxLDL was determined by ELISA in 88 men with incident CHD and in 258 age- and survey-matched controls. Hazard ratios (HRs) were estimated from conditional logistic-regression models with matching for age and survey. Baseline mean plasma oxLDL concentrations were significantly higher in subjects who subsequently experienced an event compared with controls (mean+/-SD, 110+/-32 versus 93+/-28 U/L; P< or =0.001). After adjustment for smoking, hypertension, obesity, physical activity, education, and alcohol consumption, the HR for a future CHD event in a comparison of the upper tertile of the oxLDL distribution with the lower tertile was 4.25 (95% confidence interval, 2.09 to 8.63; P<0.001). Plasma oxLDL was the strongest predictor of CHD events compared with a conventional lipoprotein profile and other traditional risk factors for CHD. When both oxLDL and C-reactive protein were simultaneously assessed in the same model, they still predicted future CHD events even after multivariable adjustment.CONCLUSIONS: Elevated concentrations of oxLDL are predictive of future CHD events in apparently healthy men. Thus, oxLDL may represent a promising risk marker for clinical CHD complications and should be evaluated in further studies.

AB - BACKGROUND: Oxidized LDL (oxLDL) is thought to play a key role in the inflammatory response in the arterial vessel wall.METHODS AND RESULTS: In a prospective, nested, case-control study, the association between plasma oxLDL and risk of an acute coronary heart disease (CHD) event was investigated in men without prevalent CHD or diabetes mellitus at baseline. Subjects came from 2 population-based MONICA/KORA Augsburg surveys conducted in the years 1989-1990 and 1994-1995 with follow-up in 1998 (mean+/-SD follow-up time, 5.6+/-2.6 years). OxLDL was determined by ELISA in 88 men with incident CHD and in 258 age- and survey-matched controls. Hazard ratios (HRs) were estimated from conditional logistic-regression models with matching for age and survey. Baseline mean plasma oxLDL concentrations were significantly higher in subjects who subsequently experienced an event compared with controls (mean+/-SD, 110+/-32 versus 93+/-28 U/L; P< or =0.001). After adjustment for smoking, hypertension, obesity, physical activity, education, and alcohol consumption, the HR for a future CHD event in a comparison of the upper tertile of the oxLDL distribution with the lower tertile was 4.25 (95% confidence interval, 2.09 to 8.63; P<0.001). Plasma oxLDL was the strongest predictor of CHD events compared with a conventional lipoprotein profile and other traditional risk factors for CHD. When both oxLDL and C-reactive protein were simultaneously assessed in the same model, they still predicted future CHD events even after multivariable adjustment.CONCLUSIONS: Elevated concentrations of oxLDL are predictive of future CHD events in apparently healthy men. Thus, oxLDL may represent a promising risk marker for clinical CHD complications and should be evaluated in further studies.

KW - Acute Disease

KW - Biomarkers/blood

KW - Coronary Disease/blood

KW - Humans

KW - Lipoproteins, LDL/blood

KW - Male

KW - Middle Aged

KW - Predictive Value of Tests

KW - Prospective Studies

KW - Reference Values

KW - Regression Analysis

U2 - 10.1161/CIRCULATIONAHA.104.529297

DO - 10.1161/CIRCULATIONAHA.104.529297

M3 - SCORING: Journal article

C2 - 16043640

VL - 112

SP - 651

EP - 657

JO - CIRCULATION

JF - CIRCULATION

SN - 0009-7322

IS - 5

ER -