Plasma microRNA signature is associated with risk stratification in prostate cancer patients
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Plasma microRNA signature is associated with risk stratification in prostate cancer patients. / Al-Qatati, Abeer; Akrong, Christine; Stevic, Ines; Pantel, Klaus; Awe, Julius; Saranchuk, Jeff; Drachenberg, Darrel; Mai, Sabine; Schwarzenbach, Heidi.
in: INT J CANCER, Jahrgang 141, Nr. 6, 15.09.2017, S. 1231-1239.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Plasma microRNA signature is associated with risk stratification in prostate cancer patients
AU - Al-Qatati, Abeer
AU - Akrong, Christine
AU - Stevic, Ines
AU - Pantel, Klaus
AU - Awe, Julius
AU - Saranchuk, Jeff
AU - Drachenberg, Darrel
AU - Mai, Sabine
AU - Schwarzenbach, Heidi
N1 - © 2017 UICC.
PY - 2017/9/15
Y1 - 2017/9/15
N2 - The aim of this study was to establish a unique expression profile of circulating cell-free microRNAs (miRNAs) capable of differentiating between prostate cancer (PCa) patients with high-risk and intermediate-risk Gleason scores. MiRNA expression profiles were determined in plasma samples from 79 treatment-naïve PCa patients, 1-2 follow-up samples after radical prostatectomy (RP) from 51 out of the 79 PCa patients, and 33 healthy men, using a quantitative real-time PCR-based array containing 48 selected miRNAs. We identified 27 up- and 2 downregulated plasma miRNAs in PCa patients compared with healthy men. Most of the upregulated miRNA levels were also associated with increasing PSA levels and Gleason scores. Particularly, the levels of miR-16 (p = 0.002), miR-148a (p = 0.006) and miR-195 (p = 0.006) significantly correlated with high-risk Gleason scores, whereby miR-148a (p = 0.003) was also significantly associated with increasing PSA values. The high miRNA levels before RP remained increased in the postsurgical plasma samples. Our findings show a network of deregulated plasma miRNAs. In particular, miR-16, miR-148a and miR-195 are involved in the regulation of the PI3K/Akt signaling pathway. These miRNAs may be promising therapeutic targets for high-risk PCa stratification.
AB - The aim of this study was to establish a unique expression profile of circulating cell-free microRNAs (miRNAs) capable of differentiating between prostate cancer (PCa) patients with high-risk and intermediate-risk Gleason scores. MiRNA expression profiles were determined in plasma samples from 79 treatment-naïve PCa patients, 1-2 follow-up samples after radical prostatectomy (RP) from 51 out of the 79 PCa patients, and 33 healthy men, using a quantitative real-time PCR-based array containing 48 selected miRNAs. We identified 27 up- and 2 downregulated plasma miRNAs in PCa patients compared with healthy men. Most of the upregulated miRNA levels were also associated with increasing PSA levels and Gleason scores. Particularly, the levels of miR-16 (p = 0.002), miR-148a (p = 0.006) and miR-195 (p = 0.006) significantly correlated with high-risk Gleason scores, whereby miR-148a (p = 0.003) was also significantly associated with increasing PSA values. The high miRNA levels before RP remained increased in the postsurgical plasma samples. Our findings show a network of deregulated plasma miRNAs. In particular, miR-16, miR-148a and miR-195 are involved in the regulation of the PI3K/Akt signaling pathway. These miRNAs may be promising therapeutic targets for high-risk PCa stratification.
KW - Journal Article
U2 - 10.1002/ijc.30815
DO - 10.1002/ijc.30815
M3 - SCORING: Journal article
C2 - 28571116
VL - 141
SP - 1231
EP - 1239
JO - INT J CANCER
JF - INT J CANCER
SN - 0020-7136
IS - 6
ER -
