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Plasma concentrations of N-terminal brain natriuretic peptide in healthy children, adolescents, and young adults: effect of age and gender.

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Plasma concentrations of N-terminal brain natriuretic peptide in healthy children, adolescents, and young adults: effect of age and gender. / Mir, T S; Flato, M; Falkenberg, J; Haddad, M; Budden, R; Weil, J; Albers, S; Laer, S.

in: PEDIATR CARDIOL, Jahrgang 27, Nr. 1, 1, 01.09.2005, S. 73-77.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Mir, TS, Flato, M, Falkenberg, J, Haddad, M, Budden, R, Weil, J, Albers, S & Laer, S 2005, 'Plasma concentrations of N-terminal brain natriuretic peptide in healthy children, adolescents, and young adults: effect of age and gender.', PEDIATR CARDIOL, Jg. 27, Nr. 1, 1, S. 73-77. https://doi.org/10.1007/s00246-005-1022-4

APA

Mir, T. S., Flato, M., Falkenberg, J., Haddad, M., Budden, R., Weil, J., Albers, S., & Laer, S. (2005). Plasma concentrations of N-terminal brain natriuretic peptide in healthy children, adolescents, and young adults: effect of age and gender. PEDIATR CARDIOL, 27(1), 73-77. [1]. https://doi.org/10.1007/s00246-005-1022-4

Vancouver

Mir TS, Flato M, Falkenberg J, Haddad M, Budden R, Weil J et al. Plasma concentrations of N-terminal brain natriuretic peptide in healthy children, adolescents, and young adults: effect of age and gender. PEDIATR CARDIOL. 2005 Sep 1;27(1):73-77. 1. https://doi.org/10.1007/s00246-005-1022-4

Bibtex

@article{11aa1fd4149d454ba1dfc0e8469d134a,
title = "Plasma concentrations of N-terminal brain natriuretic peptide in healthy children, adolescents, and young adults: effect of age and gender.",
abstract = "Children with congenital heart disease need adequate diagnostic classification regarding their cardiovascular status (CVS). N-terminal brain natriuretic peptide (N-BNP) plasma concentration indicates dysfunction of the cardiovascular system and guides decisions concerning treatment and prognosis. Reference values are established for adults, with age-dependent increasing values and higher values in women. To avoid misclassification concerning the CVS, a large group of healthy children and adolescents can be used show the relationship between gender, age, and N-BNP and these can serve as reference values. N-BNP was measured in 434 healthy subjects (240 female and 194 male) with ages ranging from 0 to 32 years without any cardiovascular disease or renal or hepatic impairment. Measurements were performed with an electrochemiluminescence immunoassay from Roche Diagnostics. Mean N-BNP decreased from 12.6 fmol/ml (0-9 years; n = 79) to 9.41 fmol/ml (10-14 years; n = 154) and in adolescents from 6.1 (15-19 years; n = 99) to 4.8 fmol/ml (> 19 years; n = 102) in adults (p <0.05). Mean N-BNP concerning gender did not differ in any age group younger than 19 years. In contrast, the adult female group had 78% higher N-BNP compared to the male group (p <0.05). There was a significant peak in N-BNP at the age of 12-14 years. This study shows that reference values for N-BNP differed profoundly in children compared to adults and were up to 260% higher in children without any gender difference. Therefore, these reference values will help to avoid CVS misclassification in children for the biomarker N-BNP.",
keywords = "Adolescent, Adult, Age Factors, Child, Child, Preschool, Female, Humans, Infant, Male, Natriuretic Peptide, Brain/blood, Peptide Fragments/blood, Reference Values, Sex Factors",
author = "Mir, {T S} and M Flato and J Falkenberg and M Haddad and R Budden and J Weil and S Albers and S Laer",
year = "2005",
month = sep,
day = "1",
doi = "10.1007/s00246-005-1022-4",
language = "English",
volume = "27",
pages = "73--77",
journal = "PEDIATR CARDIOL",
issn = "0172-0643",
publisher = "Springer New York",
number = "1",

}

RIS

TY - JOUR

T1 - Plasma concentrations of N-terminal brain natriuretic peptide in healthy children, adolescents, and young adults: effect of age and gender.

AU - Mir, T S

AU - Flato, M

AU - Falkenberg, J

AU - Haddad, M

AU - Budden, R

AU - Weil, J

AU - Albers, S

AU - Laer, S

PY - 2005/9/1

Y1 - 2005/9/1

N2 - Children with congenital heart disease need adequate diagnostic classification regarding their cardiovascular status (CVS). N-terminal brain natriuretic peptide (N-BNP) plasma concentration indicates dysfunction of the cardiovascular system and guides decisions concerning treatment and prognosis. Reference values are established for adults, with age-dependent increasing values and higher values in women. To avoid misclassification concerning the CVS, a large group of healthy children and adolescents can be used show the relationship between gender, age, and N-BNP and these can serve as reference values. N-BNP was measured in 434 healthy subjects (240 female and 194 male) with ages ranging from 0 to 32 years without any cardiovascular disease or renal or hepatic impairment. Measurements were performed with an electrochemiluminescence immunoassay from Roche Diagnostics. Mean N-BNP decreased from 12.6 fmol/ml (0-9 years; n = 79) to 9.41 fmol/ml (10-14 years; n = 154) and in adolescents from 6.1 (15-19 years; n = 99) to 4.8 fmol/ml (> 19 years; n = 102) in adults (p <0.05). Mean N-BNP concerning gender did not differ in any age group younger than 19 years. In contrast, the adult female group had 78% higher N-BNP compared to the male group (p <0.05). There was a significant peak in N-BNP at the age of 12-14 years. This study shows that reference values for N-BNP differed profoundly in children compared to adults and were up to 260% higher in children without any gender difference. Therefore, these reference values will help to avoid CVS misclassification in children for the biomarker N-BNP.

AB - Children with congenital heart disease need adequate diagnostic classification regarding their cardiovascular status (CVS). N-terminal brain natriuretic peptide (N-BNP) plasma concentration indicates dysfunction of the cardiovascular system and guides decisions concerning treatment and prognosis. Reference values are established for adults, with age-dependent increasing values and higher values in women. To avoid misclassification concerning the CVS, a large group of healthy children and adolescents can be used show the relationship between gender, age, and N-BNP and these can serve as reference values. N-BNP was measured in 434 healthy subjects (240 female and 194 male) with ages ranging from 0 to 32 years without any cardiovascular disease or renal or hepatic impairment. Measurements were performed with an electrochemiluminescence immunoassay from Roche Diagnostics. Mean N-BNP decreased from 12.6 fmol/ml (0-9 years; n = 79) to 9.41 fmol/ml (10-14 years; n = 154) and in adolescents from 6.1 (15-19 years; n = 99) to 4.8 fmol/ml (> 19 years; n = 102) in adults (p <0.05). Mean N-BNP concerning gender did not differ in any age group younger than 19 years. In contrast, the adult female group had 78% higher N-BNP compared to the male group (p <0.05). There was a significant peak in N-BNP at the age of 12-14 years. This study shows that reference values for N-BNP differed profoundly in children compared to adults and were up to 260% higher in children without any gender difference. Therefore, these reference values will help to avoid CVS misclassification in children for the biomarker N-BNP.

KW - Adolescent

KW - Adult

KW - Age Factors

KW - Child

KW - Child, Preschool

KW - Female

KW - Humans

KW - Infant

KW - Male

KW - Natriuretic Peptide, Brain/blood

KW - Peptide Fragments/blood

KW - Reference Values

KW - Sex Factors

U2 - 10.1007/s00246-005-1022-4

DO - 10.1007/s00246-005-1022-4

M3 - SCORING: Journal article

C2 - 16132298

VL - 27

SP - 73

EP - 77

JO - PEDIATR CARDIOL

JF - PEDIATR CARDIOL

SN - 0172-0643

IS - 1

M1 - 1

ER -