Plasma concentrations of asymmetric dimethylarginine (ADMA) in metabolic syndrome.
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Plasma concentrations of asymmetric dimethylarginine (ADMA) in metabolic syndrome. / Garcia, Ronald G; Perez, Maritza; Maas, Renke; Schwedhelm, Edzard; Böger, Rainer; López-Jaramillo, Patricio.
in: INT J CARDIOL, Jahrgang 122, Nr. 2, 2, 2007, S. 176-178.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Plasma concentrations of asymmetric dimethylarginine (ADMA) in metabolic syndrome.
AU - Garcia, Ronald G
AU - Perez, Maritza
AU - Maas, Renke
AU - Schwedhelm, Edzard
AU - Böger, Rainer
AU - López-Jaramillo, Patricio
PY - 2007
Y1 - 2007
N2 - Elevated circulating ADMA levels have been proposed as the pivotal link between insulin resistance, cardiovascular disease, and endothelial dysfunction in Caucasian population. To evaluate whether there is an association between plasma ADMA concentrations and insulin resistance in Hispanic population, we identified metabolic syndrome NCEP-ATP III criteria and measured ADMA and L-arginine plasma concentrations in 147 Colombian young males consecutively included in a cross-sectional study. In contrast to inflammatory markers, ADMA was not found to be elevated in subjects with metabolic syndrome, furthermore, no significant association between ADMA concentrations and insulin resistance degree was found. In conclusion, our results suggest that at least in our population, ADMA does not seem to be implicated in the pathophysiology of metabolic syndrome. Ethnic-specific or environmental differences in the etiologic mechanisms of metabolic syndrome need to be elucidated in further studies.
AB - Elevated circulating ADMA levels have been proposed as the pivotal link between insulin resistance, cardiovascular disease, and endothelial dysfunction in Caucasian population. To evaluate whether there is an association between plasma ADMA concentrations and insulin resistance in Hispanic population, we identified metabolic syndrome NCEP-ATP III criteria and measured ADMA and L-arginine plasma concentrations in 147 Colombian young males consecutively included in a cross-sectional study. In contrast to inflammatory markers, ADMA was not found to be elevated in subjects with metabolic syndrome, furthermore, no significant association between ADMA concentrations and insulin resistance degree was found. In conclusion, our results suggest that at least in our population, ADMA does not seem to be implicated in the pathophysiology of metabolic syndrome. Ethnic-specific or environmental differences in the etiologic mechanisms of metabolic syndrome need to be elucidated in further studies.
M3 - SCORING: Zeitschriftenaufsatz
VL - 122
SP - 176
EP - 178
JO - INT J CARDIOL
JF - INT J CARDIOL
SN - 0167-5273
IS - 2
M1 - 2
ER -
