Plasma 25-hydroxyvitamin D3, folate and vitamin B12 biomarkers among international colorectal cancer patients: a pilot study
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Plasma 25-hydroxyvitamin D3, folate and vitamin B12 biomarkers among international colorectal cancer patients: a pilot study. / Ulrich, Cornelia M; Toriola, Adetunji T; Siegel, Erin M; Brenner, Hermann; Chang-Claude, Jenny; Abbenhardt, Clare; Kotzmann, Jana; Song, Xiaoling; Owen, Robert W; Hoffmeister, Michael; Becher, Heiko; Shibata, David; Vickers, Kathy; Rush, Shannon K; Makar, Karen; Würtele, Gerd; Haubner, Roswitha; Sellers, Thomas A; Grady, William; ColoCare Consortium.
in: J Nutr Sci, Jahrgang 2, Nr. e9, 2013, S. 1-6.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Plasma 25-hydroxyvitamin D3, folate and vitamin B12 biomarkers among international colorectal cancer patients: a pilot study
AU - Ulrich, Cornelia M
AU - Toriola, Adetunji T
AU - Siegel, Erin M
AU - Brenner, Hermann
AU - Chang-Claude, Jenny
AU - Abbenhardt, Clare
AU - Kotzmann, Jana
AU - Song, Xiaoling
AU - Owen, Robert W
AU - Hoffmeister, Michael
AU - Becher, Heiko
AU - Shibata, David
AU - Vickers, Kathy
AU - Rush, Shannon K
AU - Makar, Karen
AU - Würtele, Gerd
AU - Haubner, Roswitha
AU - Sellers, Thomas A
AU - Grady, William
AU - ColoCare Consortium
PY - 2013
Y1 - 2013
N2 - Vitamin D and folate are associated with decreased colorectal cancer risk and their association with colorectal cancer prognosis is under investigation. Weassessed the levels of plasma 25-hydroxyvitamin D3 (25(OH)D3), folate and vitamin B12 in an international pilot study in order to determine variability ofthese biomarkers based on geographical location. Plasma 25(OH)D3, folate and vitamin B12 concentrations were measured in 149 invasive, newlydiagnosed colorectal cancer cases from Heidelberg (Germany), Seattle (WA, USA), and Tampa (FL, USA) and in ninety-one age- and sex-matched controls.Their associations with potential predictors were assessed using multivariate linear regression analyses. Plasma 25(OH)D3, folate and vitamin B12 concentrationsdiffered by location. Other predictors were season for 25(OH)D3 and tumour stage (vitamin B12). Season-corrected average 25(OH)D3 concentrationswere higher in Heidelberg (31·7 ng/ml; range 11·0–83·0 ng/ml) than in Seattle (23·3 ng/ml; range 4·0–80·0 ng/ml) and Tampa (21·1 ng/ml; range4·6–51·6 ng/ml). In Heidelberg, a strong seasonal variation was observed. Folate (11·1 ng/ml) and vitamin B12 (395 pg/ml) concentrations in Heidelbergwere lower than those in Seattle (25·3 ng/ml and 740 pg/ml, respectively) and Tampa (23·8 ng/ml and 522 pg/ml, respectively). Differences in plasma 25(OH)D3 and folate concentrations between Heidelberg and the US sites were observed, probably reflecting variation in outdoor activities and sun-avoidancebehaviour during summer as well as in folic acid fortification and supplement use. Intra-site differences at each study location were greater thanbetween-location variability, suggesting that individual health behaviours play a significant role. Nevertheless, the intra-site differences we observed maybe due to chance because of the limited sample size. Our pilot study illustrates the value of an international cohort in studying colorectal cancer prognosisto discern geographical differences in a broad range of exposures.
AB - Vitamin D and folate are associated with decreased colorectal cancer risk and their association with colorectal cancer prognosis is under investigation. Weassessed the levels of plasma 25-hydroxyvitamin D3 (25(OH)D3), folate and vitamin B12 in an international pilot study in order to determine variability ofthese biomarkers based on geographical location. Plasma 25(OH)D3, folate and vitamin B12 concentrations were measured in 149 invasive, newlydiagnosed colorectal cancer cases from Heidelberg (Germany), Seattle (WA, USA), and Tampa (FL, USA) and in ninety-one age- and sex-matched controls.Their associations with potential predictors were assessed using multivariate linear regression analyses. Plasma 25(OH)D3, folate and vitamin B12 concentrationsdiffered by location. Other predictors were season for 25(OH)D3 and tumour stage (vitamin B12). Season-corrected average 25(OH)D3 concentrationswere higher in Heidelberg (31·7 ng/ml; range 11·0–83·0 ng/ml) than in Seattle (23·3 ng/ml; range 4·0–80·0 ng/ml) and Tampa (21·1 ng/ml; range4·6–51·6 ng/ml). In Heidelberg, a strong seasonal variation was observed. Folate (11·1 ng/ml) and vitamin B12 (395 pg/ml) concentrations in Heidelbergwere lower than those in Seattle (25·3 ng/ml and 740 pg/ml, respectively) and Tampa (23·8 ng/ml and 522 pg/ml, respectively). Differences in plasma 25(OH)D3 and folate concentrations between Heidelberg and the US sites were observed, probably reflecting variation in outdoor activities and sun-avoidancebehaviour during summer as well as in folic acid fortification and supplement use. Intra-site differences at each study location were greater thanbetween-location variability, suggesting that individual health behaviours play a significant role. Nevertheless, the intra-site differences we observed maybe due to chance because of the limited sample size. Our pilot study illustrates the value of an international cohort in studying colorectal cancer prognosisto discern geographical differences in a broad range of exposures.
U2 - 10.1017/jns.2012.28
DO - 10.1017/jns.2012.28
M3 - SCORING: Zeitschriftenaufsatz
VL - 2
SP - 1
EP - 6
JO - J Nutr Sci
JF - J Nutr Sci
SN - 2048-6790
IS - e9
ER -
