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PITX1 Is a Regulator of TERT Expression in Prostate Cancer with Prognostic Power

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PITX1 Is a Regulator of TERT Expression in Prostate Cancer with Prognostic Power. / Poos, Alexandra M; Schroeder, Cornelia; Jaishankar, Neeraja; Röll, Daniela; Oswald, Marcus; Meiners, Jan; Braun, Delia M; Knotz, Caroline; Frank, Lukas; Gunkel, Manuel; Spilger, Roman; Wollmann, Thomas; Polonski, Adam; Makrypidi-Fraune, Georgia; Fraune, Christoph; Graefen, Markus; Chung, Inn; Stenzel, Alexander; Erfle, Holger; Rohr, Karl; Baniahmad, Aria; Sauter, Guido; Rippe, Karsten; Simon, Ronald; Koenig, Rainer.

in: CANCERS, Jahrgang 14, Nr. 5, 1267, 01.03.2022.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Poos, AM, Schroeder, C, Jaishankar, N, Röll, D, Oswald, M, Meiners, J, Braun, DM, Knotz, C, Frank, L, Gunkel, M, Spilger, R, Wollmann, T, Polonski, A, Makrypidi-Fraune, G, Fraune, C, Graefen, M, Chung, I, Stenzel, A, Erfle, H, Rohr, K, Baniahmad, A, Sauter, G, Rippe, K, Simon, R & Koenig, R 2022, 'PITX1 Is a Regulator of TERT Expression in Prostate Cancer with Prognostic Power', CANCERS, Jg. 14, Nr. 5, 1267. https://doi.org/10.3390/cancers14051267

APA

Poos, A. M., Schroeder, C., Jaishankar, N., Röll, D., Oswald, M., Meiners, J., Braun, D. M., Knotz, C., Frank, L., Gunkel, M., Spilger, R., Wollmann, T., Polonski, A., Makrypidi-Fraune, G., Fraune, C., Graefen, M., Chung, I., Stenzel, A., Erfle, H., ... Koenig, R. (2022). PITX1 Is a Regulator of TERT Expression in Prostate Cancer with Prognostic Power. CANCERS, 14(5), [1267]. https://doi.org/10.3390/cancers14051267

Vancouver

Poos AM, Schroeder C, Jaishankar N, Röll D, Oswald M, Meiners J et al. PITX1 Is a Regulator of TERT Expression in Prostate Cancer with Prognostic Power. CANCERS. 2022 Mär 1;14(5). 1267. https://doi.org/10.3390/cancers14051267

Bibtex

@article{e8ac83e825e54c38a154a5e15553580d,
title = "PITX1 Is a Regulator of TERT Expression in Prostate Cancer with Prognostic Power",
abstract = "The current risk stratification in prostate cancer (PCa) is frequently insufficient to adequately predict disease development and outcome. One hallmark of cancer is telomere maintenance. For telomere maintenance, PCa cells exclusively employ telomerase, making it essential for this cancer entity. However, TERT, the catalytic protein component of the reverse transcriptase telomerase, itself does not suit as a prognostic marker for prostate cancer as it is rather low expressed. We investigated if, instead of TERT, transcription factors regulating TERT may suit as prognostic markers. To identify transcription factors regulating TERT, we developed and applied a new gene regulatory modeling strategy to a comprehensive transcriptome dataset of 445 primary PCa. Six transcription factors were predicted as TERT regulators, and most prominently, the developmental morphogenic factor PITX1. PITX1 expression positively correlated with telomere staining intensity in PCa tumor samples. Functional assays and chromatin immune-precipitation showed that PITX1 activates TERT expression in PCa cells. Clinically, we observed that PITX1 is an excellent prognostic marker, as concluded from an analysis of more than 15,000 PCa samples. PITX1 expression in tumor samples associated with (i) increased Ki67 expression indicating increased tumor growth, (ii) a worse prognosis, and (iii) correlated with telomere length.",
author = "Poos, {Alexandra M} and Cornelia Schroeder and Neeraja Jaishankar and Daniela R{\"o}ll and Marcus Oswald and Jan Meiners and Braun, {Delia M} and Caroline Knotz and Lukas Frank and Manuel Gunkel and Roman Spilger and Thomas Wollmann and Adam Polonski and Georgia Makrypidi-Fraune and Christoph Fraune and Markus Graefen and Inn Chung and Alexander Stenzel and Holger Erfle and Karl Rohr and Aria Baniahmad and Guido Sauter and Karsten Rippe and Ronald Simon and Rainer Koenig",
year = "2022",
month = mar,
day = "1",
doi = "10.3390/cancers14051267",
language = "English",
volume = "14",
journal = "CANCERS",
issn = "2072-6694",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "5",

}

RIS

TY - JOUR

T1 - PITX1 Is a Regulator of TERT Expression in Prostate Cancer with Prognostic Power

AU - Poos, Alexandra M

AU - Schroeder, Cornelia

AU - Jaishankar, Neeraja

AU - Röll, Daniela

AU - Oswald, Marcus

AU - Meiners, Jan

AU - Braun, Delia M

AU - Knotz, Caroline

AU - Frank, Lukas

AU - Gunkel, Manuel

AU - Spilger, Roman

AU - Wollmann, Thomas

AU - Polonski, Adam

AU - Makrypidi-Fraune, Georgia

AU - Fraune, Christoph

AU - Graefen, Markus

AU - Chung, Inn

AU - Stenzel, Alexander

AU - Erfle, Holger

AU - Rohr, Karl

AU - Baniahmad, Aria

AU - Sauter, Guido

AU - Rippe, Karsten

AU - Simon, Ronald

AU - Koenig, Rainer

PY - 2022/3/1

Y1 - 2022/3/1

N2 - The current risk stratification in prostate cancer (PCa) is frequently insufficient to adequately predict disease development and outcome. One hallmark of cancer is telomere maintenance. For telomere maintenance, PCa cells exclusively employ telomerase, making it essential for this cancer entity. However, TERT, the catalytic protein component of the reverse transcriptase telomerase, itself does not suit as a prognostic marker for prostate cancer as it is rather low expressed. We investigated if, instead of TERT, transcription factors regulating TERT may suit as prognostic markers. To identify transcription factors regulating TERT, we developed and applied a new gene regulatory modeling strategy to a comprehensive transcriptome dataset of 445 primary PCa. Six transcription factors were predicted as TERT regulators, and most prominently, the developmental morphogenic factor PITX1. PITX1 expression positively correlated with telomere staining intensity in PCa tumor samples. Functional assays and chromatin immune-precipitation showed that PITX1 activates TERT expression in PCa cells. Clinically, we observed that PITX1 is an excellent prognostic marker, as concluded from an analysis of more than 15,000 PCa samples. PITX1 expression in tumor samples associated with (i) increased Ki67 expression indicating increased tumor growth, (ii) a worse prognosis, and (iii) correlated with telomere length.

AB - The current risk stratification in prostate cancer (PCa) is frequently insufficient to adequately predict disease development and outcome. One hallmark of cancer is telomere maintenance. For telomere maintenance, PCa cells exclusively employ telomerase, making it essential for this cancer entity. However, TERT, the catalytic protein component of the reverse transcriptase telomerase, itself does not suit as a prognostic marker for prostate cancer as it is rather low expressed. We investigated if, instead of TERT, transcription factors regulating TERT may suit as prognostic markers. To identify transcription factors regulating TERT, we developed and applied a new gene regulatory modeling strategy to a comprehensive transcriptome dataset of 445 primary PCa. Six transcription factors were predicted as TERT regulators, and most prominently, the developmental morphogenic factor PITX1. PITX1 expression positively correlated with telomere staining intensity in PCa tumor samples. Functional assays and chromatin immune-precipitation showed that PITX1 activates TERT expression in PCa cells. Clinically, we observed that PITX1 is an excellent prognostic marker, as concluded from an analysis of more than 15,000 PCa samples. PITX1 expression in tumor samples associated with (i) increased Ki67 expression indicating increased tumor growth, (ii) a worse prognosis, and (iii) correlated with telomere length.

U2 - 10.3390/cancers14051267

DO - 10.3390/cancers14051267

M3 - SCORING: Journal article

C2 - 35267575

VL - 14

JO - CANCERS

JF - CANCERS

SN - 2072-6694

IS - 5

M1 - 1267

ER -