Physician-reported Clinical Unmet Needs, Burden and Treatment Patterns of Paediatric Psoriasis Patients: A US and EU Real-world Evidence Study
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Physician-reported Clinical Unmet Needs, Burden and Treatment Patterns of Paediatric Psoriasis Patients: A US and EU Real-world Evidence Study. / Seyger, Marieke M B; Augustin, Matthias; Sticherling, Michael; Bachhuber, Teresa; Fang, Juanzhi; Hetherington, James; Lucas, James; Meakin, Sophie; Richardson, Craig; Paller, Amy S.
in: ACTA DERM-VENEREOL, Jahrgang 102, adv00660, 28.02.2022.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Physician-reported Clinical Unmet Needs, Burden and Treatment Patterns of Paediatric Psoriasis Patients: A US and EU Real-world Evidence Study
AU - Seyger, Marieke M B
AU - Augustin, Matthias
AU - Sticherling, Michael
AU - Bachhuber, Teresa
AU - Fang, Juanzhi
AU - Hetherington, James
AU - Lucas, James
AU - Meakin, Sophie
AU - Richardson, Craig
AU - Paller, Amy S
PY - 2022/2/28
Y1 - 2022/2/28
N2 - This study is a retrospective analysis using data collected from the Adelphi Paediatric Psoriasis Disease-Specific Programme cross-sectional survey. Despite being treated for their psoriasis, a substantial proportion of paediatric patients presented with moderate (18.3%) or severe (1.3%) disease at sampling; 42.9% and 92.0% had a body surface area (BSA) of >10%, and 38.8% and 100.0% had a Psoriasis Area Severity Index (PASI) score >10, respectively. Overall, 69.9% of patients had only ever been treated with a topical therapy for their psoriasis. For patients with moderate or severe disease at sampling, 16.3% and 14.4% were currently receiving conventional systemics or biologic therapy, respectively. There is a clinical unmet need in this paediatric population; a considerable percentage of patients still experienced moderate or severe disease and persistent psoriasis symptoms, with numerous body areas affected. A significant proportion of patients were undertreated, which may explain the high burden of disease observed.
AB - This study is a retrospective analysis using data collected from the Adelphi Paediatric Psoriasis Disease-Specific Programme cross-sectional survey. Despite being treated for their psoriasis, a substantial proportion of paediatric patients presented with moderate (18.3%) or severe (1.3%) disease at sampling; 42.9% and 92.0% had a body surface area (BSA) of >10%, and 38.8% and 100.0% had a Psoriasis Area Severity Index (PASI) score >10, respectively. Overall, 69.9% of patients had only ever been treated with a topical therapy for their psoriasis. For patients with moderate or severe disease at sampling, 16.3% and 14.4% were currently receiving conventional systemics or biologic therapy, respectively. There is a clinical unmet need in this paediatric population; a considerable percentage of patients still experienced moderate or severe disease and persistent psoriasis symptoms, with numerous body areas affected. A significant proportion of patients were undertreated, which may explain the high burden of disease observed.
KW - Child
KW - Cross-Sectional Studies
KW - Humans
KW - Physicians
KW - Psoriasis/diagnosis
KW - Retrospective Studies
KW - Severity of Illness Index
U2 - 10.2340/actadv.v101.981
DO - 10.2340/actadv.v101.981
M3 - SCORING: Journal article
C2 - 34935993
VL - 102
JO - ACTA DERM-VENEREOL
JF - ACTA DERM-VENEREOL
SN - 0001-5555
M1 - adv00660
ER -
