Physical exercise in multiple sclerosis: supportive care or a putative disease-modifying treatment.
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Physical exercise in multiple sclerosis: supportive care or a putative disease-modifying treatment. / Heesen, Christoph; Romberg, Anders; Gold, Stefan; Schulz, Karl-Heinz.
in: EXPERT REV NEUROTHER, Jahrgang 6, Nr. 3, 3, 2006, S. 347-355.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Physical exercise in multiple sclerosis: supportive care or a putative disease-modifying treatment.
AU - Heesen, Christoph
AU - Romberg, Anders
AU - Gold, Stefan
AU - Schulz, Karl-Heinz
PY - 2006
Y1 - 2006
N2 - Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease affecting young adults and leading to considerable disability. For many years, patients have been advised to avoid physical activity. Today, however, an increasing number of studies have shown beneficial effects of exercise training in MS. It has been reported that such programs not only improve fitness parameters but can also enhance quality of life and beneficially affect some suggestive disability measures. Pilot studies even indicate a neuroprotective potential. This review summarizes the findings of the major clinical trials on exercise in MS. Possible biological effect mediators, such as neurotrophic factors or anti-inflammatory cytokines, will be discussed. Exercise management guidelines will be proposed and possible further research strategies are presented.
AB - Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease affecting young adults and leading to considerable disability. For many years, patients have been advised to avoid physical activity. Today, however, an increasing number of studies have shown beneficial effects of exercise training in MS. It has been reported that such programs not only improve fitness parameters but can also enhance quality of life and beneficially affect some suggestive disability measures. Pilot studies even indicate a neuroprotective potential. This review summarizes the findings of the major clinical trials on exercise in MS. Possible biological effect mediators, such as neurotrophic factors or anti-inflammatory cytokines, will be discussed. Exercise management guidelines will be proposed and possible further research strategies are presented.
M3 - SCORING: Zeitschriftenaufsatz
VL - 6
SP - 347
EP - 355
JO - EXPERT REV NEUROTHER
JF - EXPERT REV NEUROTHER
SN - 1473-7175
IS - 3
M1 - 3
ER -
