Photodynamic therapy in the upper aerodigestive tract. Overview and outlook
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Photodynamic therapy in the upper aerodigestive tract. Overview and outlook. / Volgger, Veronika; Betz, Christian Stephan.
in: J BIOPHOTONICS, Jahrgang 9, Nr. 11-12, 12.2016, S. 1302-1313.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Photodynamic therapy in the upper aerodigestive tract. Overview and outlook
AU - Volgger, Veronika
AU - Betz, Christian Stephan
N1 - © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2016/12
Y1 - 2016/12
N2 - The gold standard in the treatment of (pre)malignancies of the upper aerodigestive tract (UADT) is either surgery or (chemo)radiotherapy. Nevertheless, there are special indications where an alternative treatment, such as photodynamic therapy (PDT), might be as effective for and better tolerated by the patients concerned. This article aims to present a contemporary and comprehensive review on the role of photodynamic therapy in the treatment of (pre)malignancies of the UADT. PubMed was searched for "photodynamic therapy larynx/oral cavity/oropharynx/head and neck" in 01/2016. PDT can be efficient in the treatment of recurrent, residual or multiple carcinomas of the UADT without other treatment options. It has also been used with success in the treatment of early oral or laryngeal carcinomas, widespread precancerous lesions or "difficult-to-treat" skin cancer, even though these treatments are off-label. For now, unsolved scientific and economical challenges hinder the methods spread. In special cases, PDT is a highly effective method to treat head and neck (pre)malignancies. Nevertheless, further clinical studies are needed to better define its true value in head and neck oncology.
AB - The gold standard in the treatment of (pre)malignancies of the upper aerodigestive tract (UADT) is either surgery or (chemo)radiotherapy. Nevertheless, there are special indications where an alternative treatment, such as photodynamic therapy (PDT), might be as effective for and better tolerated by the patients concerned. This article aims to present a contemporary and comprehensive review on the role of photodynamic therapy in the treatment of (pre)malignancies of the UADT. PubMed was searched for "photodynamic therapy larynx/oral cavity/oropharynx/head and neck" in 01/2016. PDT can be efficient in the treatment of recurrent, residual or multiple carcinomas of the UADT without other treatment options. It has also been used with success in the treatment of early oral or laryngeal carcinomas, widespread precancerous lesions or "difficult-to-treat" skin cancer, even though these treatments are off-label. For now, unsolved scientific and economical challenges hinder the methods spread. In special cases, PDT is a highly effective method to treat head and neck (pre)malignancies. Nevertheless, further clinical studies are needed to better define its true value in head and neck oncology.
KW - Head and Neck Neoplasms
KW - Humans
KW - Laryngeal Neoplasms
KW - Mouth Neoplasms
KW - Photochemotherapy
KW - Skin Neoplasms
KW - Journal Article
KW - Review
U2 - 10.1002/jbio.201600036
DO - 10.1002/jbio.201600036
M3 - SCORING: Review article
C2 - 27010591
VL - 9
SP - 1302
EP - 1313
JO - J BIOPHOTONICS
JF - J BIOPHOTONICS
SN - 1864-063X
IS - 11-12
ER -