Pharmacokinetics and immunodynamics of basiliximab in pediatric renal transplant recipients on mycophenolate mofetil comedication.
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Pharmacokinetics and immunodynamics of basiliximab in pediatric renal transplant recipients on mycophenolate mofetil comedication. / Höcker, Britta; Kovarik, John M; Daniel, Volker; Opelz, Gerhard; Fehrenbach, Henry; Holder, Martin; Hoppe, Bernd; Hoyer, Peter; Jungraithmayr, Therese C; Köpf-Shakib, Sabine; Laube, Guido F; Müller-Wiefel, Dirk E.; Offner, Gisela; Plank, Christian; Schröder, Monika; Weber, Lutz T; Zimmerhackl, Lothar B; Tönshoff, Burkhard.
in: TRANSPLANTATION, Jahrgang 86, Nr. 9, 9, 2008, S. 1234-1240.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Pharmacokinetics and immunodynamics of basiliximab in pediatric renal transplant recipients on mycophenolate mofetil comedication.
AU - Höcker, Britta
AU - Kovarik, John M
AU - Daniel, Volker
AU - Opelz, Gerhard
AU - Fehrenbach, Henry
AU - Holder, Martin
AU - Hoppe, Bernd
AU - Hoyer, Peter
AU - Jungraithmayr, Therese C
AU - Köpf-Shakib, Sabine
AU - Laube, Guido F
AU - Müller-Wiefel, Dirk E.
AU - Offner, Gisela
AU - Plank, Christian
AU - Schröder, Monika
AU - Weber, Lutz T
AU - Zimmerhackl, Lothar B
AU - Tönshoff, Burkhard
PY - 2008
Y1 - 2008
N2 - BACKGROUND: The aim of this substudy within a prospective, multicenter, placebo-controlled trial was to assess the pharmacokinetics and immunodynamics of basiliximab in pediatric renal transplant recipients on comedication with mycophenolate mofetil (MMF). METHODS: Eighty-two patients aged 3 to 18 years, receiving cyclosporine microemulsion, MMF, corticosteroids, and basiliximab or placebo were investigated. Basiliximab serum concentrations were determined by ELISA, CD25+, and CD122+ T lymphocytes by flow cytometry. RESULTS: Basiliximab clearance adjusted to body surface area was significantly (P
AB - BACKGROUND: The aim of this substudy within a prospective, multicenter, placebo-controlled trial was to assess the pharmacokinetics and immunodynamics of basiliximab in pediatric renal transplant recipients on comedication with mycophenolate mofetil (MMF). METHODS: Eighty-two patients aged 3 to 18 years, receiving cyclosporine microemulsion, MMF, corticosteroids, and basiliximab or placebo were investigated. Basiliximab serum concentrations were determined by ELISA, CD25+, and CD122+ T lymphocytes by flow cytometry. RESULTS: Basiliximab clearance adjusted to body surface area was significantly (P
M3 - SCORING: Zeitschriftenaufsatz
VL - 86
SP - 1234
EP - 1240
JO - TRANSPLANTATION
JF - TRANSPLANTATION
SN - 0041-1337
IS - 9
M1 - 9
ER -