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PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

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PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis. / LeBleu, Valerie S; O'Connell, Joyce T; Gonzalez Herrera, Karina N; Wikman-Kocher, Harriet; Pantel, Klaus; Haigis, Marcia C; de Carvalho, Fernanda Machado; Damascena, Aline; Domingos Chinen, Ludmilla Thome; Rocha, Rafael M; Asara, John M; Kalluri, Raghu.

in: NAT CELL BIOL, Jahrgang 16, Nr. 10, 01.10.2014, S. 992-1003.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

LeBleu, VS, O'Connell, JT, Gonzalez Herrera, KN, Wikman-Kocher, H, Pantel, K, Haigis, MC, de Carvalho, FM, Damascena, A, Domingos Chinen, LT, Rocha, RM, Asara, JM & Kalluri, R 2014, 'PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis', NAT CELL BIOL, Jg. 16, Nr. 10, S. 992-1003. https://doi.org/10.1038/ncb3039

APA

LeBleu, V. S., O'Connell, J. T., Gonzalez Herrera, K. N., Wikman-Kocher, H., Pantel, K., Haigis, M. C., de Carvalho, F. M., Damascena, A., Domingos Chinen, L. T., Rocha, R. M., Asara, J. M., & Kalluri, R. (2014). PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis. NAT CELL BIOL, 16(10), 992-1003. https://doi.org/10.1038/ncb3039

Vancouver

LeBleu VS, O'Connell JT, Gonzalez Herrera KN, Wikman-Kocher H, Pantel K, Haigis MC et al. PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis. NAT CELL BIOL. 2014 Okt 1;16(10):992-1003. https://doi.org/10.1038/ncb3039

Bibtex

@article{222616a5d3b54d9880e07a42a6041a7c,
title = "PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis",
abstract = "Cancer cells can divert metabolites into anabolic pathways to support their rapid proliferation and to accumulate the cellular building blocks required for tumour growth. However, the specific bioenergetic profile of invasive and metastatic cancer cells is unknown. Here we report that migratory/invasive cancer cells specifically favour mitochondrial respiration and increased ATP production. Invasive cancer cells use the transcription coactivator peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PPARGC1A, also known as PGC-1α) to enhance oxidative phosphorylation, mitochondrial biogenesis and the oxygen consumption rate. Clinical analysis of human invasive breast cancers revealed a strong correlation between PGC-1α expression in invasive cancer cells and the formation of distant metastases. Silencing of PGC-1α in cancer cells suspended their invasive potential and attenuated metastasis without affecting proliferation, primary tumour growth or the epithelial-to-mesenchymal program. Inherent genetics of cancer cells can determine the transcriptome framework associated with invasion and metastasis, and mitochondrial biogenesis and respiration induced by PGC-1α are also essential for functional motility of cancer cells and metastasis.",
keywords = "Animals, Blotting, Western, Breast Neoplasms, Cell Line, Tumor, Cell Movement, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Nude, Microscopy, Electron, Transmission, Middle Aged, Mitochondria, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasms, Oxidative Phosphorylation, Oxygen Consumption, RNA Interference, Reverse Transcriptase Polymerase Chain Reaction, Transcription Factors",
author = "LeBleu, {Valerie S} and O'Connell, {Joyce T} and {Gonzalez Herrera}, {Karina N} and Harriet Wikman-Kocher and Klaus Pantel and Haigis, {Marcia C} and {de Carvalho}, {Fernanda Machado} and Aline Damascena and {Domingos Chinen}, {Ludmilla Thome} and Rocha, {Rafael M} and Asara, {John M} and Raghu Kalluri",
year = "2014",
month = oct,
day = "1",
doi = "10.1038/ncb3039",
language = "English",
volume = "16",
pages = "992--1003",
journal = "NAT CELL BIOL",
issn = "1465-7392",
publisher = "NATURE PUBLISHING GROUP",
number = "10",

}

RIS

TY - JOUR

T1 - PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

AU - LeBleu, Valerie S

AU - O'Connell, Joyce T

AU - Gonzalez Herrera, Karina N

AU - Wikman-Kocher, Harriet

AU - Pantel, Klaus

AU - Haigis, Marcia C

AU - de Carvalho, Fernanda Machado

AU - Damascena, Aline

AU - Domingos Chinen, Ludmilla Thome

AU - Rocha, Rafael M

AU - Asara, John M

AU - Kalluri, Raghu

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Cancer cells can divert metabolites into anabolic pathways to support their rapid proliferation and to accumulate the cellular building blocks required for tumour growth. However, the specific bioenergetic profile of invasive and metastatic cancer cells is unknown. Here we report that migratory/invasive cancer cells specifically favour mitochondrial respiration and increased ATP production. Invasive cancer cells use the transcription coactivator peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PPARGC1A, also known as PGC-1α) to enhance oxidative phosphorylation, mitochondrial biogenesis and the oxygen consumption rate. Clinical analysis of human invasive breast cancers revealed a strong correlation between PGC-1α expression in invasive cancer cells and the formation of distant metastases. Silencing of PGC-1α in cancer cells suspended their invasive potential and attenuated metastasis without affecting proliferation, primary tumour growth or the epithelial-to-mesenchymal program. Inherent genetics of cancer cells can determine the transcriptome framework associated with invasion and metastasis, and mitochondrial biogenesis and respiration induced by PGC-1α are also essential for functional motility of cancer cells and metastasis.

AB - Cancer cells can divert metabolites into anabolic pathways to support their rapid proliferation and to accumulate the cellular building blocks required for tumour growth. However, the specific bioenergetic profile of invasive and metastatic cancer cells is unknown. Here we report that migratory/invasive cancer cells specifically favour mitochondrial respiration and increased ATP production. Invasive cancer cells use the transcription coactivator peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PPARGC1A, also known as PGC-1α) to enhance oxidative phosphorylation, mitochondrial biogenesis and the oxygen consumption rate. Clinical analysis of human invasive breast cancers revealed a strong correlation between PGC-1α expression in invasive cancer cells and the formation of distant metastases. Silencing of PGC-1α in cancer cells suspended their invasive potential and attenuated metastasis without affecting proliferation, primary tumour growth or the epithelial-to-mesenchymal program. Inherent genetics of cancer cells can determine the transcriptome framework associated with invasion and metastasis, and mitochondrial biogenesis and respiration induced by PGC-1α are also essential for functional motility of cancer cells and metastasis.

KW - Animals

KW - Blotting, Western

KW - Breast Neoplasms

KW - Cell Line, Tumor

KW - Cell Movement

KW - Female

KW - Gene Expression Profiling

KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - Immunohistochemistry

KW - Male

KW - Mice, Inbred BALB C

KW - Mice, Inbred C57BL

KW - Mice, Nude

KW - Microscopy, Electron, Transmission

KW - Middle Aged

KW - Mitochondria

KW - Neoplasm Invasiveness

KW - Neoplasm Metastasis

KW - Neoplasms

KW - Oxidative Phosphorylation

KW - Oxygen Consumption

KW - RNA Interference

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Transcription Factors

U2 - 10.1038/ncb3039

DO - 10.1038/ncb3039

M3 - SCORING: Journal article

C2 - 25241037

VL - 16

SP - 992

EP - 1003

JO - NAT CELL BIOL

JF - NAT CELL BIOL

SN - 1465-7392

IS - 10

ER -