Perspectives on sipuleucel-T: Its role in the prostate cancer treatment paradigm
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Perspectives on sipuleucel-T: Its role in the prostate cancer treatment paradigm. / Gulley, James L; Mulders, Peter; Albers, Peter; Banchereau, Jacques; Bolla, Michel; Pantel, Klaus; Powles, Thomas.
in: ONCOIMMUNOLOGY, Jahrgang 5, Nr. 4, 04.2016, S. e1107698.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Perspectives on sipuleucel-T: Its role in the prostate cancer treatment paradigm
AU - Gulley, James L
AU - Mulders, Peter
AU - Albers, Peter
AU - Banchereau, Jacques
AU - Bolla, Michel
AU - Pantel, Klaus
AU - Powles, Thomas
PY - 2016/4
Y1 - 2016/4
N2 - Sipuleucel-T is an autologous cellular immunotherapy approved in the US for patients with asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC). This significant advance for mCRPC treatment provides healthcare professionals with another effective therapy to extend survival. As an immunotherapy, sipuleucel-T possesses specific characteristics differentiating it from traditional therapies. At a roundtable meeting of experts, sipuleucel-T data were discussed, focusing on interpretation and clinical implications. Important differences between immunotherapies and traditional therapies were explored, e.g., mode of action, outcomes, data consistency and robustness, timing of sipuleucel-T treatment, and future perspectives in areas such as short-term markers of long-term benefit.
AB - Sipuleucel-T is an autologous cellular immunotherapy approved in the US for patients with asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC). This significant advance for mCRPC treatment provides healthcare professionals with another effective therapy to extend survival. As an immunotherapy, sipuleucel-T possesses specific characteristics differentiating it from traditional therapies. At a roundtable meeting of experts, sipuleucel-T data were discussed, focusing on interpretation and clinical implications. Important differences between immunotherapies and traditional therapies were explored, e.g., mode of action, outcomes, data consistency and robustness, timing of sipuleucel-T treatment, and future perspectives in areas such as short-term markers of long-term benefit.
U2 - 10.1080/2162402X.2015.1107698
DO - 10.1080/2162402X.2015.1107698
M3 - SCORING: Journal article
C2 - 27141392
VL - 5
SP - e1107698
JO - ONCOIMMUNOLOGY
JF - ONCOIMMUNOLOGY
SN - 2162-402X
IS - 4
ER -