Persistence of microscopic human cancers in mice: alterations in the angiogenic balance accompanies loss of tumor dormancy.
Standard
Persistence of microscopic human cancers in mice: alterations in the angiogenic balance accompanies loss of tumor dormancy. / Udagawa, Taturo; Fernandez, Antonio; Achilles, Eike-Gert; Folkman, Judah; D'Amato, Robert J.
in: FASEB J, Jahrgang 16, Nr. 11, 11, 2002, S. 1361-1370.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Persistence of microscopic human cancers in mice: alterations in the angiogenic balance accompanies loss of tumor dormancy.
AU - Udagawa, Taturo
AU - Fernandez, Antonio
AU - Achilles, Eike-Gert
AU - Folkman, Judah
AU - D'Amato, Robert J
PY - 2002
Y1 - 2002
N2 - Some human tumor lines do not form visible tumors when inoculated into immunosuppressed mice. The fate of these human tumor lines was followed by transfecting them with green fluorescence protein before inoculating them into mice. Although the tumor lines failed to grow progressively, they formed small dormant microscopic foci maintained at constant mass by balanced proliferation and apoptosis. Transfecting the cells with either VEGF165 or activated c-Ha-ras induced loss of dormancy, which correlated with a shift in the angiogenic balance toward increased vascularity with reduced tumor cell apoptosis. These results support a model in which loss of dormancy is controlled in part by a switch to an angiogenic phenotype. These tumor lines may serve as models for investigating the cellular mechanisms controlling dormancy and identifying those factors that promote the loss of balanced proliferation and apoptosis. Finally, these models may prove useful in the design and testing of therapies directed toward eradicating dormant tumors and preventing tumor recurrence.
AB - Some human tumor lines do not form visible tumors when inoculated into immunosuppressed mice. The fate of these human tumor lines was followed by transfecting them with green fluorescence protein before inoculating them into mice. Although the tumor lines failed to grow progressively, they formed small dormant microscopic foci maintained at constant mass by balanced proliferation and apoptosis. Transfecting the cells with either VEGF165 or activated c-Ha-ras induced loss of dormancy, which correlated with a shift in the angiogenic balance toward increased vascularity with reduced tumor cell apoptosis. These results support a model in which loss of dormancy is controlled in part by a switch to an angiogenic phenotype. These tumor lines may serve as models for investigating the cellular mechanisms controlling dormancy and identifying those factors that promote the loss of balanced proliferation and apoptosis. Finally, these models may prove useful in the design and testing of therapies directed toward eradicating dormant tumors and preventing tumor recurrence.
M3 - SCORING: Zeitschriftenaufsatz
VL - 16
SP - 1361
EP - 1370
JO - FASEB J
JF - FASEB J
SN - 0892-6638
IS - 11
M1 - 11
ER -
