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Peroxiredoxins 3 and 4 are overexpressed in prostate cancer tissue and affect the proliferation of prostate cancer cells in vitro.

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Peroxiredoxins 3 and 4 are overexpressed in prostate cancer tissue and affect the proliferation of prostate cancer cells in vitro. / Ummanni, Ramesh; Barreto, Frederico; Venz, Simone; Scharf, Christian; Barett, Christine; Mannsperger, Heiko A; Brase, Jan Christoph; Kuner, Ruprecht; Schlomm, Thorsten; Sauter, Guido; Sültmann, Holger; Korf, Ulrike; Bokemeyer, Carsten; Walther, Reinhard; Brümmendorf, Tim; Balabanov, Stefan.

in: J PROTEOME RES, Jahrgang 11, Nr. 4, 4, 2012, S. 2452-2466.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Ummanni, R, Barreto, F, Venz, S, Scharf, C, Barett, C, Mannsperger, HA, Brase, JC, Kuner, R, Schlomm, T, Sauter, G, Sültmann, H, Korf, U, Bokemeyer, C, Walther, R, Brümmendorf, T & Balabanov, S 2012, 'Peroxiredoxins 3 and 4 are overexpressed in prostate cancer tissue and affect the proliferation of prostate cancer cells in vitro.', J PROTEOME RES, Jg. 11, Nr. 4, 4, S. 2452-2466. <http://www.ncbi.nlm.nih.gov/pubmed/22424448?dopt=Citation>

APA

Ummanni, R., Barreto, F., Venz, S., Scharf, C., Barett, C., Mannsperger, H. A., Brase, J. C., Kuner, R., Schlomm, T., Sauter, G., Sültmann, H., Korf, U., Bokemeyer, C., Walther, R., Brümmendorf, T., & Balabanov, S. (2012). Peroxiredoxins 3 and 4 are overexpressed in prostate cancer tissue and affect the proliferation of prostate cancer cells in vitro. J PROTEOME RES, 11(4), 2452-2466. [4]. http://www.ncbi.nlm.nih.gov/pubmed/22424448?dopt=Citation

Vancouver

Ummanni R, Barreto F, Venz S, Scharf C, Barett C, Mannsperger HA et al. Peroxiredoxins 3 and 4 are overexpressed in prostate cancer tissue and affect the proliferation of prostate cancer cells in vitro. J PROTEOME RES. 2012;11(4):2452-2466. 4.

Bibtex

@article{078ccca9eff8430a827678c66bf599a5,
title = "Peroxiredoxins 3 and 4 are overexpressed in prostate cancer tissue and affect the proliferation of prostate cancer cells in vitro.",
abstract = "The present study aimed to investigate the proteome profiling of surgically treated prostate cancers. Hereto, 2D-DIGE and mass spectrometry were performed for protein identification, and data validation for peroxiredoxin 3 and 4 (PRDX3 and PRDX4) was accomplished by reverse phase protein arrays (RPPA). The Formal Concept Analysis (FCA) method was applied to assess whether the TMPRSS2-ERG gene fusion could influence the degree of overexpression of PRDX3 and PRDX4 in prostate cancer. Lastly, we performed an in vitro functional characterization of both PRDX3 and PRDX4 using the classical human prostate cancer cell lines DU145 and LNCaP. Reverse phase protein arrays verified that the overexpression of both PRDX3 and PRDX4 in tumor samples is negatively correlated with the presence of the TMPRSS2-ERG gene fusion. Functional characterization of PRDX3 and PRDX4 activity in PCa cell lines suggests a role of these members of the peroxiredoxin family in the pathophysiology of this tumor entity.",
keywords = "Humans, Male, Cell Line, Tumor, Gene Fusion, Gene Expression Regulation, Neoplastic, Proteomics, Cell Growth Processes/physiology, Peroxiredoxin III/*biosynthesis/genetics/metabolism, Peroxiredoxins/*biosynthesis/genetics/metabolism, Prostate/chemistry/metabolism, Prostatic Neoplasms/chemistry/genetics/*metabolism/*pathology, Proteome/analysis, Humans, Male, Cell Line, Tumor, Gene Fusion, Gene Expression Regulation, Neoplastic, Proteomics, Cell Growth Processes/physiology, Peroxiredoxin III/*biosynthesis/genetics/metabolism, Peroxiredoxins/*biosynthesis/genetics/metabolism, Prostate/chemistry/metabolism, Prostatic Neoplasms/chemistry/genetics/*metabolism/*pathology, Proteome/analysis",
author = "Ramesh Ummanni and Frederico Barreto and Simone Venz and Christian Scharf and Christine Barett and Mannsperger, {Heiko A} and Brase, {Jan Christoph} and Ruprecht Kuner and Thorsten Schlomm and Guido Sauter and Holger S{\"u}ltmann and Ulrike Korf and Carsten Bokemeyer and Reinhard Walther and Tim Br{\"u}mmendorf and Stefan Balabanov",
year = "2012",
language = "English",
volume = "11",
pages = "2452--2466",
journal = "J PROTEOME RES",
issn = "1535-3893",
publisher = "American Chemical Society",
number = "4",

}

RIS

TY - JOUR

T1 - Peroxiredoxins 3 and 4 are overexpressed in prostate cancer tissue and affect the proliferation of prostate cancer cells in vitro.

AU - Ummanni, Ramesh

AU - Barreto, Frederico

AU - Venz, Simone

AU - Scharf, Christian

AU - Barett, Christine

AU - Mannsperger, Heiko A

AU - Brase, Jan Christoph

AU - Kuner, Ruprecht

AU - Schlomm, Thorsten

AU - Sauter, Guido

AU - Sültmann, Holger

AU - Korf, Ulrike

AU - Bokemeyer, Carsten

AU - Walther, Reinhard

AU - Brümmendorf, Tim

AU - Balabanov, Stefan

PY - 2012

Y1 - 2012

N2 - The present study aimed to investigate the proteome profiling of surgically treated prostate cancers. Hereto, 2D-DIGE and mass spectrometry were performed for protein identification, and data validation for peroxiredoxin 3 and 4 (PRDX3 and PRDX4) was accomplished by reverse phase protein arrays (RPPA). The Formal Concept Analysis (FCA) method was applied to assess whether the TMPRSS2-ERG gene fusion could influence the degree of overexpression of PRDX3 and PRDX4 in prostate cancer. Lastly, we performed an in vitro functional characterization of both PRDX3 and PRDX4 using the classical human prostate cancer cell lines DU145 and LNCaP. Reverse phase protein arrays verified that the overexpression of both PRDX3 and PRDX4 in tumor samples is negatively correlated with the presence of the TMPRSS2-ERG gene fusion. Functional characterization of PRDX3 and PRDX4 activity in PCa cell lines suggests a role of these members of the peroxiredoxin family in the pathophysiology of this tumor entity.

AB - The present study aimed to investigate the proteome profiling of surgically treated prostate cancers. Hereto, 2D-DIGE and mass spectrometry were performed for protein identification, and data validation for peroxiredoxin 3 and 4 (PRDX3 and PRDX4) was accomplished by reverse phase protein arrays (RPPA). The Formal Concept Analysis (FCA) method was applied to assess whether the TMPRSS2-ERG gene fusion could influence the degree of overexpression of PRDX3 and PRDX4 in prostate cancer. Lastly, we performed an in vitro functional characterization of both PRDX3 and PRDX4 using the classical human prostate cancer cell lines DU145 and LNCaP. Reverse phase protein arrays verified that the overexpression of both PRDX3 and PRDX4 in tumor samples is negatively correlated with the presence of the TMPRSS2-ERG gene fusion. Functional characterization of PRDX3 and PRDX4 activity in PCa cell lines suggests a role of these members of the peroxiredoxin family in the pathophysiology of this tumor entity.

KW - Humans

KW - Male

KW - Cell Line, Tumor

KW - Gene Fusion

KW - Gene Expression Regulation, Neoplastic

KW - Proteomics

KW - Cell Growth Processes/physiology

KW - Peroxiredoxin III/biosynthesis/genetics/metabolism

KW - Peroxiredoxins/biosynthesis/genetics/metabolism

KW - Prostate/chemistry/metabolism

KW - Prostatic Neoplasms/chemistry/genetics/metabolism/pathology

KW - Proteome/analysis

KW - Humans

KW - Male

KW - Cell Line, Tumor

KW - Gene Fusion

KW - Gene Expression Regulation, Neoplastic

KW - Proteomics

KW - Cell Growth Processes/physiology

KW - Peroxiredoxin III/biosynthesis/genetics/metabolism

KW - Peroxiredoxins/biosynthesis/genetics/metabolism

KW - Prostate/chemistry/metabolism

KW - Prostatic Neoplasms/chemistry/genetics/metabolism/pathology

KW - Proteome/analysis

M3 - SCORING: Journal article

VL - 11

SP - 2452

EP - 2466

JO - J PROTEOME RES

JF - J PROTEOME RES

SN - 1535-3893

IS - 4

M1 - 4

ER -