Perioperative chemotherapy in upper tract urothelial carcinoma: a comprehensive review
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Perioperative chemotherapy in upper tract urothelial carcinoma: a comprehensive review. / Aziz, Atiqullah; Dobruch, Jakub; Hendricksen, Kees; Kluth, Luis A; Necchi, Andrea; Noon, Aidan; Rink, Michael; Roghmann, Florian; Seiler, Roland; Gontero, Paolo; Kassouf, Wassim; Shariat, Shahrokh F; Xylinas, Evanguelos; Young Academic Urologists Urothelial Carcinoma Group of the European Association of Urology.
in: WORLD J UROL, Jahrgang 35, Nr. 9, 09.2017, S. 1401-1407.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Perioperative chemotherapy in upper tract urothelial carcinoma: a comprehensive review
AU - Aziz, Atiqullah
AU - Dobruch, Jakub
AU - Hendricksen, Kees
AU - Kluth, Luis A
AU - Necchi, Andrea
AU - Noon, Aidan
AU - Rink, Michael
AU - Roghmann, Florian
AU - Seiler, Roland
AU - Gontero, Paolo
AU - Kassouf, Wassim
AU - Shariat, Shahrokh F
AU - Xylinas, Evanguelos
AU - Young Academic Urologists Urothelial Carcinoma Group of the European Association of Urology
PY - 2017/9
Y1 - 2017/9
N2 - PURPOSE: To evaluate the role of neoadjuvant (NAC) and adjuvant chemotherapy (AC) in patients with upper tract urothelial carcinoma (UTUC) treated with radical nephroureterectomy (RNU).METHODS: A comprehensive review of the current literature was performed searching for all studies investigating NAC and AC in UTUC in MEDLINE and https://clinicaltrials.gov , prior to April 2016. The following keywords were used: "ureteral neoplasms," "urothelium," "ureter," "upper tract urothelial," "chemotherapy," "adjuvant," "neoadjuvant" and relevant variants.RESULTS: No randomized trials investigated the role of AC or NAC for UTUC. There was one prospective study with n = 36 patients investigating AC with carboplatin-paclitaxel. We included 14 retrospective studies (four in the NAC and ten in the AC setting), with a total of 694 patients receiving cisplatin-based or non-cisplatin-based AC after RNU and 1437 patients undergoing RNU alone. We found that the current literature, mainly based on retrospective studies, suggests significant overall and cancer-specific survival benefits for AC in UTUC. NAC appears promising, with favorable pathologic response rates up to 14%.CONCLUSIONS: Evidence is scarce for both NAC and AC use in UTUC. This comprehensive review suggests promising response rates for NAC and a survival benefit for patients treated with AC. Prospective randomized trials are needed to establish the role of AC and NAC in UTUC.
AB - PURPOSE: To evaluate the role of neoadjuvant (NAC) and adjuvant chemotherapy (AC) in patients with upper tract urothelial carcinoma (UTUC) treated with radical nephroureterectomy (RNU).METHODS: A comprehensive review of the current literature was performed searching for all studies investigating NAC and AC in UTUC in MEDLINE and https://clinicaltrials.gov , prior to April 2016. The following keywords were used: "ureteral neoplasms," "urothelium," "ureter," "upper tract urothelial," "chemotherapy," "adjuvant," "neoadjuvant" and relevant variants.RESULTS: No randomized trials investigated the role of AC or NAC for UTUC. There was one prospective study with n = 36 patients investigating AC with carboplatin-paclitaxel. We included 14 retrospective studies (four in the NAC and ten in the AC setting), with a total of 694 patients receiving cisplatin-based or non-cisplatin-based AC after RNU and 1437 patients undergoing RNU alone. We found that the current literature, mainly based on retrospective studies, suggests significant overall and cancer-specific survival benefits for AC in UTUC. NAC appears promising, with favorable pathologic response rates up to 14%.CONCLUSIONS: Evidence is scarce for both NAC and AC use in UTUC. This comprehensive review suggests promising response rates for NAC and a survival benefit for patients treated with AC. Prospective randomized trials are needed to establish the role of AC and NAC in UTUC.
U2 - 10.1007/s00345-016-1995-z
DO - 10.1007/s00345-016-1995-z
M3 - SCORING: Journal article
C2 - 28074261
VL - 35
SP - 1401
EP - 1407
JO - WORLD J UROL
JF - WORLD J UROL
SN - 0724-4983
IS - 9
ER -