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Percentage of high-grade tumour volume does not meaningfully improve prediction of early biochemical recurrence after radical prostatectomy compared with Gleason score

Standard

Percentage of high-grade tumour volume does not meaningfully improve prediction of early biochemical recurrence after radical prostatectomy compared with Gleason score. / Hansen, Jens; Bianchi, Marco; Sun, Maxine; Rink, Michael; Castiglione, Fabio; Abdollah, Firas; Steuber, Thomas; Ahyai, Sascha A; Steurer, Stefan; Göbel, Cosima; Freschi, Massimo; Montorsi, Francesco; Shariat, Shahrokh F; Fisch, Margit; Graefen, Markus; Karakiewicz, Pierre I; Briganti, Alberto; Chun, Felix K-H.

in: BJU INT, Jahrgang 113, Nr. 3, 01.03.2014, S. 399-407.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Hansen, J, Bianchi, M, Sun, M, Rink, M, Castiglione, F, Abdollah, F, Steuber, T, Ahyai, SA, Steurer, S, Göbel, C, Freschi, M, Montorsi, F, Shariat, SF, Fisch, M, Graefen, M, Karakiewicz, PI, Briganti, A & Chun, FK-H 2014, 'Percentage of high-grade tumour volume does not meaningfully improve prediction of early biochemical recurrence after radical prostatectomy compared with Gleason score', BJU INT, Jg. 113, Nr. 3, S. 399-407. https://doi.org/10.1111/bju.12424

APA

Hansen, J., Bianchi, M., Sun, M., Rink, M., Castiglione, F., Abdollah, F., Steuber, T., Ahyai, S. A., Steurer, S., Göbel, C., Freschi, M., Montorsi, F., Shariat, S. F., Fisch, M., Graefen, M., Karakiewicz, P. I., Briganti, A., & Chun, F. K-H. (2014). Percentage of high-grade tumour volume does not meaningfully improve prediction of early biochemical recurrence after radical prostatectomy compared with Gleason score. BJU INT, 113(3), 399-407. https://doi.org/10.1111/bju.12424

Vancouver

Hansen J, Bianchi M, Sun M, Rink M, Castiglione F, Abdollah F et al. Percentage of high-grade tumour volume does not meaningfully improve prediction of early biochemical recurrence after radical prostatectomy compared with Gleason score. BJU INT. 2014 Mär 1;113(3):399-407. https://doi.org/10.1111/bju.12424

Bibtex

@article{fc8f135ee9bc448e91b7d508d8ad3151,
title = "Percentage of high-grade tumour volume does not meaningfully improve prediction of early biochemical recurrence after radical prostatectomy compared with Gleason score",
abstract = "OBJECTIVE: To examine whether percentage of tumour volume (%TV) and percentage of high-grade tumour volume (%HGTV) help to better identify men at higher risk of early biochemical recurrence (BCR) after radical prostatectomy (RP) for non-metastatic high-risk prostate cancer, as early BCR after RP might be associated with higher risk of metastases and cancer-specific mortality.PATIENTS AND METHODS: We examined the data of 595 men treated with RP for non-metastatic high-risk prostate cancer between 1992 and 2011 at two European tertiary care centres. Kaplan-Meier analyses were used to graphically depict 2-year BCR-free survival. Multivariable Cox regression models addressed early BCR. We tested whether addition of %TV and %HGTV to a multivariable Cox regression model helps to increase a model's predictive accuracy (PA) for prediction of early BCR.RESULTS: In all, 32 men (10%) with specimen-confined prostate cancer (pT2-pT3a, negative surgical margin, pN0) and 67 men (24%) with non-specimen-confined prostate cancer had early BCR. After stratification according to %HGTV (%HGTV threshold: ≤33.33 vs >33.33%), the 2-year BCR-free survival rates were respectively 93 vs 60% (log-rank P < 0.001). In multivariable Cox regression models %HGTV emerged as an independent predictor of early BCR (P < 0.001), whereas %TV did not (P > 0.05). However, adding %HGTV (regardless of its coding) to other covariates in multivariable Cox regression analysis did not increase the model's PA in a meaningful fashion compared with the use of the detailed Gleason grading system (6 vs 7a vs 7b vs 8 vs 9-10).CONCLUSIONS: In a large cohort of patients with high-risk prostate cancer, %HGTV and %TV did not improve prediction of early BCR after RP substantially, although %HGTV was an independent predictor of early BCR. Therefore, sophisticated TV/HGTV measurements do not seem to have additional benefit for early BCR prediction relative to the use of Gleason grading. However, these results need to be confirmed in larger, prospective studies.",
author = "Jens Hansen and Marco Bianchi and Maxine Sun and Michael Rink and Fabio Castiglione and Firas Abdollah and Thomas Steuber and Ahyai, {Sascha A} and Stefan Steurer and Cosima G{\"o}bel and Massimo Freschi and Francesco Montorsi and Shariat, {Shahrokh F} and Margit Fisch and Markus Graefen and Karakiewicz, {Pierre I} and Alberto Briganti and Chun, {Felix K-H}",
note = "{\textcopyright} 2013 The Authors. BJU International {\textcopyright} 2013 BJU International.",
year = "2014",
month = mar,
day = "1",
doi = "10.1111/bju.12424",
language = "English",
volume = "113",
pages = "399--407",
journal = "BJU INT",
issn = "1464-4096",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Percentage of high-grade tumour volume does not meaningfully improve prediction of early biochemical recurrence after radical prostatectomy compared with Gleason score

AU - Hansen, Jens

AU - Bianchi, Marco

AU - Sun, Maxine

AU - Rink, Michael

AU - Castiglione, Fabio

AU - Abdollah, Firas

AU - Steuber, Thomas

AU - Ahyai, Sascha A

AU - Steurer, Stefan

AU - Göbel, Cosima

AU - Freschi, Massimo

AU - Montorsi, Francesco

AU - Shariat, Shahrokh F

AU - Fisch, Margit

AU - Graefen, Markus

AU - Karakiewicz, Pierre I

AU - Briganti, Alberto

AU - Chun, Felix K-H

N1 - © 2013 The Authors. BJU International © 2013 BJU International.

PY - 2014/3/1

Y1 - 2014/3/1

N2 - OBJECTIVE: To examine whether percentage of tumour volume (%TV) and percentage of high-grade tumour volume (%HGTV) help to better identify men at higher risk of early biochemical recurrence (BCR) after radical prostatectomy (RP) for non-metastatic high-risk prostate cancer, as early BCR after RP might be associated with higher risk of metastases and cancer-specific mortality.PATIENTS AND METHODS: We examined the data of 595 men treated with RP for non-metastatic high-risk prostate cancer between 1992 and 2011 at two European tertiary care centres. Kaplan-Meier analyses were used to graphically depict 2-year BCR-free survival. Multivariable Cox regression models addressed early BCR. We tested whether addition of %TV and %HGTV to a multivariable Cox regression model helps to increase a model's predictive accuracy (PA) for prediction of early BCR.RESULTS: In all, 32 men (10%) with specimen-confined prostate cancer (pT2-pT3a, negative surgical margin, pN0) and 67 men (24%) with non-specimen-confined prostate cancer had early BCR. After stratification according to %HGTV (%HGTV threshold: ≤33.33 vs >33.33%), the 2-year BCR-free survival rates were respectively 93 vs 60% (log-rank P < 0.001). In multivariable Cox regression models %HGTV emerged as an independent predictor of early BCR (P < 0.001), whereas %TV did not (P > 0.05). However, adding %HGTV (regardless of its coding) to other covariates in multivariable Cox regression analysis did not increase the model's PA in a meaningful fashion compared with the use of the detailed Gleason grading system (6 vs 7a vs 7b vs 8 vs 9-10).CONCLUSIONS: In a large cohort of patients with high-risk prostate cancer, %HGTV and %TV did not improve prediction of early BCR after RP substantially, although %HGTV was an independent predictor of early BCR. Therefore, sophisticated TV/HGTV measurements do not seem to have additional benefit for early BCR prediction relative to the use of Gleason grading. However, these results need to be confirmed in larger, prospective studies.

AB - OBJECTIVE: To examine whether percentage of tumour volume (%TV) and percentage of high-grade tumour volume (%HGTV) help to better identify men at higher risk of early biochemical recurrence (BCR) after radical prostatectomy (RP) for non-metastatic high-risk prostate cancer, as early BCR after RP might be associated with higher risk of metastases and cancer-specific mortality.PATIENTS AND METHODS: We examined the data of 595 men treated with RP for non-metastatic high-risk prostate cancer between 1992 and 2011 at two European tertiary care centres. Kaplan-Meier analyses were used to graphically depict 2-year BCR-free survival. Multivariable Cox regression models addressed early BCR. We tested whether addition of %TV and %HGTV to a multivariable Cox regression model helps to increase a model's predictive accuracy (PA) for prediction of early BCR.RESULTS: In all, 32 men (10%) with specimen-confined prostate cancer (pT2-pT3a, negative surgical margin, pN0) and 67 men (24%) with non-specimen-confined prostate cancer had early BCR. After stratification according to %HGTV (%HGTV threshold: ≤33.33 vs >33.33%), the 2-year BCR-free survival rates were respectively 93 vs 60% (log-rank P < 0.001). In multivariable Cox regression models %HGTV emerged as an independent predictor of early BCR (P < 0.001), whereas %TV did not (P > 0.05). However, adding %HGTV (regardless of its coding) to other covariates in multivariable Cox regression analysis did not increase the model's PA in a meaningful fashion compared with the use of the detailed Gleason grading system (6 vs 7a vs 7b vs 8 vs 9-10).CONCLUSIONS: In a large cohort of patients with high-risk prostate cancer, %HGTV and %TV did not improve prediction of early BCR after RP substantially, although %HGTV was an independent predictor of early BCR. Therefore, sophisticated TV/HGTV measurements do not seem to have additional benefit for early BCR prediction relative to the use of Gleason grading. However, these results need to be confirmed in larger, prospective studies.

U2 - 10.1111/bju.12424

DO - 10.1111/bju.12424

M3 - SCORING: Journal article

C2 - 24053339

VL - 113

SP - 399

EP - 407

JO - BJU INT

JF - BJU INT

SN - 1464-4096

IS - 3

ER -