Patterns of subjective memory impairment in the elderly: association with memory performance.
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Patterns of subjective memory impairment in the elderly: association with memory performance. / Jessen, Frank; Wiese, Birgitt; Cvetanovska, Gabriela; Fuchs, Angela; Kaduszkiewicz, Hanna; Kölsch, Heike; Luck, Tobias; Mösch, Edelgard; Pentzek, Michael; Riedel-Heller, Steffi G; Werle, Jochen; Weyerer, Siegfried; Zimmermann, Thomas; Maier, Wolfgang; Bickel, Horst.
in: PSYCHOL MED, Jahrgang 37, Nr. 12, 12, 2007, S. 1753-1762.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Patterns of subjective memory impairment in the elderly: association with memory performance.
AU - Jessen, Frank
AU - Wiese, Birgitt
AU - Cvetanovska, Gabriela
AU - Fuchs, Angela
AU - Kaduszkiewicz, Hanna
AU - Kölsch, Heike
AU - Luck, Tobias
AU - Mösch, Edelgard
AU - Pentzek, Michael
AU - Riedel-Heller, Steffi G
AU - Werle, Jochen
AU - Weyerer, Siegfried
AU - Zimmermann, Thomas
AU - Maier, Wolfgang
AU - Bickel, Horst
PY - 2007
Y1 - 2007
N2 - BACKGROUND: The association of subjective memory impairment (SMI) with cognitive performance in healthy elderly subjects is poor because of confounds such as depression. However, SMI is also a predictor for future dementia. Thus, there is a need to identify subtypes of SMI that are particularly related to inferior memory performance and may represent at-risk stages for cognitive decline.METHOD: A total of 2389 unimpaired subjects were recruited from the German Study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe), as part of the German Competence Network on Dementia. Clusters of SMI according to patterns of response to SMI questions were identified. Gender, age, depressive symptoms, apolipoprotein E (apoE) genotype, delayed recall and verbal fluency were included in a Classification and Regression Tree (CART) analysis to identify discriminators between the clusters. RESULTS: We identified three clusters. Cluster 1 contained subjects without memory complaints. Cluster 2 contained subjects with general memory complaints, but mainly without memory complaints on individual tasks of daily living. Cluster 3 contained subjects with general memory complaints and complaints on individual tasks of daily living. Depressive symptoms, as the first-level discriminator, distinguished between clusters 1 and 2 versus cluster 3. In subjects with only a few depressive symptoms, delayed recall discriminated between cluster 1 versus clusters 2 and 3. CONCLUSIONS: In SMI subjects with only a minor number of depressive symptoms, memory complaints are associated with delayed recall. As delayed recall is a sensitive predictor for future cognitive decline, SMI may be the first manifestation of future dementia in elderly subjects without depression.
AB - BACKGROUND: The association of subjective memory impairment (SMI) with cognitive performance in healthy elderly subjects is poor because of confounds such as depression. However, SMI is also a predictor for future dementia. Thus, there is a need to identify subtypes of SMI that are particularly related to inferior memory performance and may represent at-risk stages for cognitive decline.METHOD: A total of 2389 unimpaired subjects were recruited from the German Study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe), as part of the German Competence Network on Dementia. Clusters of SMI according to patterns of response to SMI questions were identified. Gender, age, depressive symptoms, apolipoprotein E (apoE) genotype, delayed recall and verbal fluency were included in a Classification and Regression Tree (CART) analysis to identify discriminators between the clusters. RESULTS: We identified three clusters. Cluster 1 contained subjects without memory complaints. Cluster 2 contained subjects with general memory complaints, but mainly without memory complaints on individual tasks of daily living. Cluster 3 contained subjects with general memory complaints and complaints on individual tasks of daily living. Depressive symptoms, as the first-level discriminator, distinguished between clusters 1 and 2 versus cluster 3. In subjects with only a few depressive symptoms, delayed recall discriminated between cluster 1 versus clusters 2 and 3. CONCLUSIONS: In SMI subjects with only a minor number of depressive symptoms, memory complaints are associated with delayed recall. As delayed recall is a sensitive predictor for future cognitive decline, SMI may be the first manifestation of future dementia in elderly subjects without depression.
M3 - SCORING: Zeitschriftenaufsatz
VL - 37
SP - 1753
EP - 1762
JO - PSYCHOL MED
JF - PSYCHOL MED
SN - 0033-2917
IS - 12
M1 - 12
ER -
