Patterns of bidirectional communication between cortex and basal ganglia during movement in patients with Parkinson disease.
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Patterns of bidirectional communication between cortex and basal ganglia during movement in patients with Parkinson disease. / Lalo, Elodie; Thobois, Stéphane; Sharott, Andrew; Polo, Gustavo; Mertens, Patrick; Pogosyan, Alek; Brown, Peter.
in: J NEUROSCI, Jahrgang 28, Nr. 12, 12, 2008, S. 3008-3016.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Patterns of bidirectional communication between cortex and basal ganglia during movement in patients with Parkinson disease.
AU - Lalo, Elodie
AU - Thobois, Stéphane
AU - Sharott, Andrew
AU - Polo, Gustavo
AU - Mertens, Patrick
AU - Pogosyan, Alek
AU - Brown, Peter
PY - 2008
Y1 - 2008
N2 - Cortico-basal ganglia networks are considered to comprise several parallel and mostly segregated loops, where segregation is achieved in space through topographic connectivity. Recently, it has been suggested that functional segregation may also be achieved in the frequency domain, by selective coupling of related activities at different frequencies. So far, however, any coupling across frequency in the human has only been modeled in terms of unidirectional influences, a misplaced assumption given the looped architecture of the basal ganglia, and has been considered in static terms. Here, we investigate the pattern of bidirectional coupling between mesial and lateral cortical areas and the subthalamic nucleus (STN) at rest and during movement, with and without pharmacological dopaminergic input, in patients with Parkinson's disease. We simultaneously recorded scalp electroencephalographic activity and local field potentials from depth electrodes and deduced patterns of directed coherence between cortical and STN levels across three frequency bands [sub-beta (3-13 Hz), beta (14-35 Hz), gamma (65-90 Hz)] in the different states. Our results show (1) asymmetric bidirectional coupling between STN and both mesial and lateral cortical areas with greater drives from cortex to STN at frequencies
AB - Cortico-basal ganglia networks are considered to comprise several parallel and mostly segregated loops, where segregation is achieved in space through topographic connectivity. Recently, it has been suggested that functional segregation may also be achieved in the frequency domain, by selective coupling of related activities at different frequencies. So far, however, any coupling across frequency in the human has only been modeled in terms of unidirectional influences, a misplaced assumption given the looped architecture of the basal ganglia, and has been considered in static terms. Here, we investigate the pattern of bidirectional coupling between mesial and lateral cortical areas and the subthalamic nucleus (STN) at rest and during movement, with and without pharmacological dopaminergic input, in patients with Parkinson's disease. We simultaneously recorded scalp electroencephalographic activity and local field potentials from depth electrodes and deduced patterns of directed coherence between cortical and STN levels across three frequency bands [sub-beta (3-13 Hz), beta (14-35 Hz), gamma (65-90 Hz)] in the different states. Our results show (1) asymmetric bidirectional coupling between STN and both mesial and lateral cortical areas with greater drives from cortex to STN at frequencies
M3 - SCORING: Zeitschriftenaufsatz
VL - 28
SP - 3008
EP - 3016
JO - J NEUROSCI
JF - J NEUROSCI
SN - 0270-6474
IS - 12
M1 - 12
ER -
