Partition of metals in the maternal/fetal unit and lead-associated decreases of fetal iron and manganese: an observational biomonitoring approach.
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Partition of metals in the maternal/fetal unit and lead-associated decreases of fetal iron and manganese: an observational biomonitoring approach. / Kopp, Ricarda S; Kumbartski, Michael; Harth, Volker; Brüning, Thomas; Käfferlein, Heiko U.
in: ARCH TOXICOL, Jahrgang 86, Nr. 10, 10, 2012, S. 1571-1581.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Partition of metals in the maternal/fetal unit and lead-associated decreases of fetal iron and manganese: an observational biomonitoring approach.
AU - Kopp, Ricarda S
AU - Kumbartski, Michael
AU - Harth, Volker
AU - Brüning, Thomas
AU - Käfferlein, Heiko U
PY - 2012
Y1 - 2012
N2 - To systematically study the partition of environmental metals including lead, mercury, and cadmium and essential minerals such as iron, manganese, copper, and zinc in the maternal/fetal unit of healthy pregnant women, we analyzed blood and umbilical cord blood samples of 50 healthy mother/child pairs using a biomonitoring approach. The levels of essential minerals in healthy pregnant women were significantly different from those of the general population. The partition of essential minerals and environmental metals and their associations between maternal and umbilical cord blood were metal-specific. Lead entered the fetal environment nearly unaffected. The median fetal level was only 10 % lower than the corresponding maternal concentration (10.3 vs. 11.5 ?g/l, P = 0.0038). Mercury accumulated in the fetal unit resulting in more than a threefold increase in fetal compared to maternal exposure (1.48 vs. 0.44 ?g/l, P <0.0001). In contrast, placental transfer of Cd was limited, and median fetal exposure was
AB - To systematically study the partition of environmental metals including lead, mercury, and cadmium and essential minerals such as iron, manganese, copper, and zinc in the maternal/fetal unit of healthy pregnant women, we analyzed blood and umbilical cord blood samples of 50 healthy mother/child pairs using a biomonitoring approach. The levels of essential minerals in healthy pregnant women were significantly different from those of the general population. The partition of essential minerals and environmental metals and their associations between maternal and umbilical cord blood were metal-specific. Lead entered the fetal environment nearly unaffected. The median fetal level was only 10 % lower than the corresponding maternal concentration (10.3 vs. 11.5 ?g/l, P = 0.0038). Mercury accumulated in the fetal unit resulting in more than a threefold increase in fetal compared to maternal exposure (1.48 vs. 0.44 ?g/l, P <0.0001). In contrast, placental transfer of Cd was limited, and median fetal exposure was
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Adolescent
KW - Young Adult
KW - Cross-Sectional Studies
KW - Infant, Newborn
KW - Pregnancy
KW - Environmental Exposure/analysis
KW - Fetal Blood/chemistry
KW - Iron/blood
KW - Manganese/blood
KW - Maternal-Fetal Exchange
KW - Metals, Heavy/blood
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Adolescent
KW - Young Adult
KW - Cross-Sectional Studies
KW - Infant, Newborn
KW - Pregnancy
KW - Environmental Exposure/analysis
KW - Fetal Blood/chemistry
KW - Iron/blood
KW - Manganese/blood
KW - Maternal-Fetal Exchange
KW - Metals, Heavy/blood
M3 - SCORING: Journal article
VL - 86
SP - 1571
EP - 1581
JO - ARCH TOXICOL
JF - ARCH TOXICOL
SN - 0340-5761
IS - 10
M1 - 10
ER -
