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Parkinson's disease uncovers an underlying sensitivity of subthalamic nucleus neurons to beta-frequency cortical input in vivo

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Parkinson's disease uncovers an underlying sensitivity of subthalamic nucleus neurons to beta-frequency cortical input in vivo. / Baaske, Magdalena K.; Kormann, Eszter; Holt, Abbey B.; Gulberti, Alessandro; McNamara, Colin G.; Pötter-Nerger, Monika; Westphal, Manfred; Engel, Andreas K.; Hamel, Wolfgang; Brown, Peter; Moll, Christian K.E.; Sharott, Andrew.

in: NEUROBIOL DIS, Jahrgang 146, Nr. 146, 12.2020, S. 105119.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Baaske, MK, Kormann, E, Holt, AB, Gulberti, A, McNamara, CG, Pötter-Nerger, M, Westphal, M, Engel, AK, Hamel, W, Brown, P, Moll, CKE & Sharott, A 2020, 'Parkinson's disease uncovers an underlying sensitivity of subthalamic nucleus neurons to beta-frequency cortical input in vivo', NEUROBIOL DIS, Jg. 146, Nr. 146, S. 105119. https://doi.org/10.1016/j.nbd.2020.105119

APA

Baaske, M. K., Kormann, E., Holt, A. B., Gulberti, A., McNamara, C. G., Pötter-Nerger, M., Westphal, M., Engel, A. K., Hamel, W., Brown, P., Moll, C. K. E., & Sharott, A. (2020). Parkinson's disease uncovers an underlying sensitivity of subthalamic nucleus neurons to beta-frequency cortical input in vivo. NEUROBIOL DIS, 146(146), 105119. https://doi.org/10.1016/j.nbd.2020.105119

Vancouver

Baaske MK, Kormann E, Holt AB, Gulberti A, McNamara CG, Pötter-Nerger M et al. Parkinson's disease uncovers an underlying sensitivity of subthalamic nucleus neurons to beta-frequency cortical input in vivo. NEUROBIOL DIS. 2020 Dez;146(146):105119. https://doi.org/10.1016/j.nbd.2020.105119

Bibtex

@article{dbd45af17b754fcbb3ff5e0af2ce195c,
title = "Parkinson's disease uncovers an underlying sensitivity of subthalamic nucleus neurons to beta-frequency cortical input in vivo",
abstract = "Abnormally sustained beta-frequency synchronisation between the motor cortex and subthalamic nucleus (STN) is associated with motor symptoms in Parkinson's disease (PD). It is currently unclear whether STN neurons have a preference for beta-frequency input (12-35 Hz), rather than cortical input at other frequencies, and how such a preference would arise following dopamine depletion. To address this question, we combined analysis of cortical and STN recordings from awake human PD patients undergoing deep brain stimulation surgery with recordings of identified STN neurons in anaesthetised rats. In these patients, we demonstrate that a subset of putative STN neurons is strongly and selectively sensitive to magnitude fluctuations of cortical beta oscillations over time, linearly increasing their phase-locking strength with respect to the full range of instantaneous amplitude in the beta-frequency range. In rats, we probed the frequency response of STN neurons in the cortico-basal-ganglia-network more precisely, by recording spikes evoked by short bursts of cortical stimulation with variable frequency (4-40 Hz) and constant amplitude. In both healthy and dopamine-depleted rats, only beta-frequency stimulation led to a progressive reduction in the variability of spike timing through the stimulation train. This suggests, that the interval of beta-frequency input provides an optimal window for eliciting the next spike with high fidelity. We hypothesize, that abnormal activation of the indirect pathway, via dopamine depletion and/or cortical stimulation, could trigger an underlying sensitivity of the STN microcircuit to beta-frequency input.",
keywords = "Animals, Behavior, Animal/physiology, Beta Rhythm/physiology, Deep Brain Stimulation/methods, Motor Cortex/physiopathology, Neurons/physiology, Parkinson Disease/physiopathology, Rats, Subthalamic Nucleus/physiology",
author = "Baaske, {Magdalena K.} and Eszter Kormann and Holt, {Abbey B.} and Alessandro Gulberti and McNamara, {Colin G.} and Monika P{\"o}tter-Nerger and Manfred Westphal and Engel, {Andreas K.} and Wolfgang Hamel and Peter Brown and Moll, {Christian K.E.} and Andrew Sharott",
note = "Copyright {\textcopyright} 2020 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2020",
month = dec,
doi = "10.1016/j.nbd.2020.105119",
language = "English",
volume = "146",
pages = "105119",
journal = "NEUROBIOL DIS",
issn = "0969-9961",
publisher = "Academic Press Inc.",
number = "146",

}

RIS

TY - JOUR

T1 - Parkinson's disease uncovers an underlying sensitivity of subthalamic nucleus neurons to beta-frequency cortical input in vivo

AU - Baaske, Magdalena K.

AU - Kormann, Eszter

AU - Holt, Abbey B.

AU - Gulberti, Alessandro

AU - McNamara, Colin G.

AU - Pötter-Nerger, Monika

AU - Westphal, Manfred

AU - Engel, Andreas K.

AU - Hamel, Wolfgang

AU - Brown, Peter

AU - Moll, Christian K.E.

AU - Sharott, Andrew

N1 - Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2020/12

Y1 - 2020/12

N2 - Abnormally sustained beta-frequency synchronisation between the motor cortex and subthalamic nucleus (STN) is associated with motor symptoms in Parkinson's disease (PD). It is currently unclear whether STN neurons have a preference for beta-frequency input (12-35 Hz), rather than cortical input at other frequencies, and how such a preference would arise following dopamine depletion. To address this question, we combined analysis of cortical and STN recordings from awake human PD patients undergoing deep brain stimulation surgery with recordings of identified STN neurons in anaesthetised rats. In these patients, we demonstrate that a subset of putative STN neurons is strongly and selectively sensitive to magnitude fluctuations of cortical beta oscillations over time, linearly increasing their phase-locking strength with respect to the full range of instantaneous amplitude in the beta-frequency range. In rats, we probed the frequency response of STN neurons in the cortico-basal-ganglia-network more precisely, by recording spikes evoked by short bursts of cortical stimulation with variable frequency (4-40 Hz) and constant amplitude. In both healthy and dopamine-depleted rats, only beta-frequency stimulation led to a progressive reduction in the variability of spike timing through the stimulation train. This suggests, that the interval of beta-frequency input provides an optimal window for eliciting the next spike with high fidelity. We hypothesize, that abnormal activation of the indirect pathway, via dopamine depletion and/or cortical stimulation, could trigger an underlying sensitivity of the STN microcircuit to beta-frequency input.

AB - Abnormally sustained beta-frequency synchronisation between the motor cortex and subthalamic nucleus (STN) is associated with motor symptoms in Parkinson's disease (PD). It is currently unclear whether STN neurons have a preference for beta-frequency input (12-35 Hz), rather than cortical input at other frequencies, and how such a preference would arise following dopamine depletion. To address this question, we combined analysis of cortical and STN recordings from awake human PD patients undergoing deep brain stimulation surgery with recordings of identified STN neurons in anaesthetised rats. In these patients, we demonstrate that a subset of putative STN neurons is strongly and selectively sensitive to magnitude fluctuations of cortical beta oscillations over time, linearly increasing their phase-locking strength with respect to the full range of instantaneous amplitude in the beta-frequency range. In rats, we probed the frequency response of STN neurons in the cortico-basal-ganglia-network more precisely, by recording spikes evoked by short bursts of cortical stimulation with variable frequency (4-40 Hz) and constant amplitude. In both healthy and dopamine-depleted rats, only beta-frequency stimulation led to a progressive reduction in the variability of spike timing through the stimulation train. This suggests, that the interval of beta-frequency input provides an optimal window for eliciting the next spike with high fidelity. We hypothesize, that abnormal activation of the indirect pathway, via dopamine depletion and/or cortical stimulation, could trigger an underlying sensitivity of the STN microcircuit to beta-frequency input.

KW - Animals

KW - Behavior, Animal/physiology

KW - Beta Rhythm/physiology

KW - Deep Brain Stimulation/methods

KW - Motor Cortex/physiopathology

KW - Neurons/physiology

KW - Parkinson Disease/physiopathology

KW - Rats

KW - Subthalamic Nucleus/physiology

U2 - 10.1016/j.nbd.2020.105119

DO - 10.1016/j.nbd.2020.105119

M3 - SCORING: Journal article

C2 - 32991998

VL - 146

SP - 105119

JO - NEUROBIOL DIS

JF - NEUROBIOL DIS

SN - 0969-9961

IS - 146

ER -