Parietal epithelial cell dysfunction in crescentic glomerulonephritis

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Parietal epithelial cell dysfunction in crescentic glomerulonephritis. / Wong, Milagros N; Tharaux, Pierre-Louis; Grahammer, Florian; Puelles, Victor G.

in: CELL TISSUE RES, Jahrgang 385, Nr. 2, 08.2021, S. 345-354.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ReviewForschung

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@article{2521f7f7d3c5448eb8a5cd1874953987,
title = "Parietal epithelial cell dysfunction in crescentic glomerulonephritis",
abstract = "Crescentic glomerulonephritis represents a group of kidney diseases characterized by rapid loss of kidney function and the formation of glomerular crescents. While the role of the immune system has been extensively studied in relation to the development of crescents, recent findings show that parietal epithelial cells play a key role in the pathophysiology of crescent formation, even in the absence of immune modulation. This review highlights our current understanding of parietal epithelial cell biology and the reported physiological and pathological roles that these cells play in glomerular lesion formation, especially in the context of crescentic glomerulonephritis.",
keywords = "Animals, Epithelial Cells/pathology, Glomerulonephritis/pathology, Humans, Kidney Glomerulus/pathology",
author = "Wong, {Milagros N} and Pierre-Louis Tharaux and Florian Grahammer and Puelles, {Victor G}",
note = "{\textcopyright} 2021. The Author(s).",
year = "2021",
month = aug,
doi = "10.1007/s00441-021-03513-9",
language = "English",
volume = "385",
pages = "345--354",
journal = "CELL TISSUE RES",
issn = "0302-766X",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Parietal epithelial cell dysfunction in crescentic glomerulonephritis

AU - Wong, Milagros N

AU - Tharaux, Pierre-Louis

AU - Grahammer, Florian

AU - Puelles, Victor G

N1 - © 2021. The Author(s).

PY - 2021/8

Y1 - 2021/8

N2 - Crescentic glomerulonephritis represents a group of kidney diseases characterized by rapid loss of kidney function and the formation of glomerular crescents. While the role of the immune system has been extensively studied in relation to the development of crescents, recent findings show that parietal epithelial cells play a key role in the pathophysiology of crescent formation, even in the absence of immune modulation. This review highlights our current understanding of parietal epithelial cell biology and the reported physiological and pathological roles that these cells play in glomerular lesion formation, especially in the context of crescentic glomerulonephritis.

AB - Crescentic glomerulonephritis represents a group of kidney diseases characterized by rapid loss of kidney function and the formation of glomerular crescents. While the role of the immune system has been extensively studied in relation to the development of crescents, recent findings show that parietal epithelial cells play a key role in the pathophysiology of crescent formation, even in the absence of immune modulation. This review highlights our current understanding of parietal epithelial cell biology and the reported physiological and pathological roles that these cells play in glomerular lesion formation, especially in the context of crescentic glomerulonephritis.

KW - Animals

KW - Epithelial Cells/pathology

KW - Glomerulonephritis/pathology

KW - Humans

KW - Kidney Glomerulus/pathology

U2 - 10.1007/s00441-021-03513-9

DO - 10.1007/s00441-021-03513-9

M3 - SCORING: Review article

C2 - 34453566

VL - 385

SP - 345

EP - 354

JO - CELL TISSUE RES

JF - CELL TISSUE RES

SN - 0302-766X

IS - 2

ER -