Parietal epithelial cell dysfunction in crescentic glomerulonephritis
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Parietal epithelial cell dysfunction in crescentic glomerulonephritis. / Wong, Milagros N; Tharaux, Pierre-Louis; Grahammer, Florian; Puelles, Victor G.
in: CELL TISSUE RES, Jahrgang 385, Nr. 2, 08.2021, S. 345-354.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Parietal epithelial cell dysfunction in crescentic glomerulonephritis
AU - Wong, Milagros N
AU - Tharaux, Pierre-Louis
AU - Grahammer, Florian
AU - Puelles, Victor G
N1 - © 2021. The Author(s).
PY - 2021/8
Y1 - 2021/8
N2 - Crescentic glomerulonephritis represents a group of kidney diseases characterized by rapid loss of kidney function and the formation of glomerular crescents. While the role of the immune system has been extensively studied in relation to the development of crescents, recent findings show that parietal epithelial cells play a key role in the pathophysiology of crescent formation, even in the absence of immune modulation. This review highlights our current understanding of parietal epithelial cell biology and the reported physiological and pathological roles that these cells play in glomerular lesion formation, especially in the context of crescentic glomerulonephritis.
AB - Crescentic glomerulonephritis represents a group of kidney diseases characterized by rapid loss of kidney function and the formation of glomerular crescents. While the role of the immune system has been extensively studied in relation to the development of crescents, recent findings show that parietal epithelial cells play a key role in the pathophysiology of crescent formation, even in the absence of immune modulation. This review highlights our current understanding of parietal epithelial cell biology and the reported physiological and pathological roles that these cells play in glomerular lesion formation, especially in the context of crescentic glomerulonephritis.
KW - Animals
KW - Epithelial Cells/pathology
KW - Glomerulonephritis/pathology
KW - Humans
KW - Kidney Glomerulus/pathology
U2 - 10.1007/s00441-021-03513-9
DO - 10.1007/s00441-021-03513-9
M3 - SCORING: Review article
C2 - 34453566
VL - 385
SP - 345
EP - 354
JO - CELL TISSUE RES
JF - CELL TISSUE RES
SN - 0302-766X
IS - 2
ER -