Panicogens in patients with Post-Traumatic Stress Disorder (PTSD).
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Panicogens in patients with Post-Traumatic Stress Disorder (PTSD). / Muhtz, Christoph; Wiedemann, Klaus; Kellner, Michael.
in: CURR PHARM DESIGN, Jahrgang 18, Nr. 35, 35, 2012, S. 5608-5618.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Panicogens in patients with Post-Traumatic Stress Disorder (PTSD).
AU - Muhtz, Christoph
AU - Wiedemann, Klaus
AU - Kellner, Michael
PY - 2012
Y1 - 2012
N2 - Symptom provocation has proved its worth for understanding the pathophysiology of diseases and in general for the development of new therapeutic approaches in the medical field. In the research of anxiety disorders, investigations using experimentally induced panic attacks by various agents, such as sodium lactate, carbon dioxide, cholezystokinine-tetrapetid etc., have a long tradition and allow the exploration of usually naturally occuring spontaneous psychopathological phenomena under controlled conditions. Post-Traumatic Stress Disorder (PTSD) is a prevalent disorder that can develop following exposure to an extreme traumatic event. In DSM-IV it is currently classified as an anxiety disorder and shares phenomenological similarities with panic disorder. The use of panicogenic challenge tests is also an interesting neurobiological approach to learn more about the nature of PTSD and may be a possibility to develop new therapeutic strategies for the treatment of PTSD symptoms. Not only panic anxiety, but also flashbacks and other dissociative symptoms can be provoked by several panicogens in PTSD. The purpose of this review is to evaluate studies using panicogens in PTSD. Methodological short-comings of current studies and needed directions of further research are discussed.
AB - Symptom provocation has proved its worth for understanding the pathophysiology of diseases and in general for the development of new therapeutic approaches in the medical field. In the research of anxiety disorders, investigations using experimentally induced panic attacks by various agents, such as sodium lactate, carbon dioxide, cholezystokinine-tetrapetid etc., have a long tradition and allow the exploration of usually naturally occuring spontaneous psychopathological phenomena under controlled conditions. Post-Traumatic Stress Disorder (PTSD) is a prevalent disorder that can develop following exposure to an extreme traumatic event. In DSM-IV it is currently classified as an anxiety disorder and shares phenomenological similarities with panic disorder. The use of panicogenic challenge tests is also an interesting neurobiological approach to learn more about the nature of PTSD and may be a possibility to develop new therapeutic strategies for the treatment of PTSD symptoms. Not only panic anxiety, but also flashbacks and other dissociative symptoms can be provoked by several panicogens in PTSD. The purpose of this review is to evaluate studies using panicogens in PTSD. Methodological short-comings of current studies and needed directions of further research are discussed.
KW - Animals
KW - Humans
KW - Mental Recall
KW - Research Design
KW - Drug Design
KW - Neurobiology/methods
KW - Stress Disorders, Post-Traumatic/drug therapy/etiology/physiopathology
KW - Animals
KW - Humans
KW - Mental Recall
KW - Research Design
KW - Drug Design
KW - Neurobiology/methods
KW - Stress Disorders, Post-Traumatic/drug therapy/etiology/physiopathology
M3 - SCORING: Journal article
VL - 18
SP - 5608
EP - 5618
JO - CURR PHARM DESIGN
JF - CURR PHARM DESIGN
SN - 1381-6128
IS - 35
M1 - 35
ER -
