Pancreatic exocrine function and cardiac iron in patients with iron overload and with thalassemia.
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Pancreatic exocrine function and cardiac iron in patients with iron overload and with thalassemia. / Yamamura, Jin; Grosse, Regine; Jarisch, Andrea; Janka-Schaub, Gritta; Nielsen, Peter; Adam, Gerhard; Fischer, Roland.
in: PEDIATR BLOOD CANCER, Jahrgang 57, Nr. 4, 4, 2011, S. 674-676.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Pancreatic exocrine function and cardiac iron in patients with iron overload and with thalassemia.
AU - Yamamura, Jin
AU - Grosse, Regine
AU - Jarisch, Andrea
AU - Janka-Schaub, Gritta
AU - Nielsen, Peter
AU - Adam, Gerhard
AU - Fischer, Roland
PY - 2011
Y1 - 2011
N2 - Patients with ?-thalassemia major at risk of cardiac iron overload have to be identified to undergo myocardial iron measurements by magnetic resonance imaging (MRI), especially, in areas and centers with restricted access to MRI. Measurements of heart iron, liver iron, and pancreatic exocrine function were performed in 44 patients by MRI-R2* [the transverse relaxation rate R2* (= 1/T2*) characterizes the magnetic resonance decay from protons not being in phase with each other in contrast to R2 (= 1/T2)], biomagnetic liver susceptometry (LIC), and pancreatic serum amylase (PAM) and lipase (LIP), respectively. ROC analysis (area: 0.88) for detecting patients with cardiac R2*?> 50 sec(-1) (T2*?<20 msec) by LIP revealed a cut-off level of 19 U/L. In conclusion, patients at risk of elevated cardiac iron levels could be identified by the exocrine pancreatic lipase and amylase function parameters.
AB - Patients with ?-thalassemia major at risk of cardiac iron overload have to be identified to undergo myocardial iron measurements by magnetic resonance imaging (MRI), especially, in areas and centers with restricted access to MRI. Measurements of heart iron, liver iron, and pancreatic exocrine function were performed in 44 patients by MRI-R2* [the transverse relaxation rate R2* (= 1/T2*) characterizes the magnetic resonance decay from protons not being in phase with each other in contrast to R2 (= 1/T2)], biomagnetic liver susceptometry (LIC), and pancreatic serum amylase (PAM) and lipase (LIP), respectively. ROC analysis (area: 0.88) for detecting patients with cardiac R2*?> 50 sec(-1) (T2*?<20 msec) by LIP revealed a cut-off level of 19 U/L. In conclusion, patients at risk of elevated cardiac iron levels could be identified by the exocrine pancreatic lipase and amylase function parameters.
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Adolescent
KW - Young Adult
KW - Child
KW - ROC Curve
KW - Magnetic Resonance Imaging
KW - Electrocardiography
KW - Amylases/blood
KW - Iron/analysis
KW - Iron Overload/blood/etiology
KW - Lipase/blood
KW - Liver/chemistry
KW - Myocardium/chemistry
KW - Pancreas, Exocrine/metabolism
KW - Thalassemia/blood/complications
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Adolescent
KW - Young Adult
KW - Child
KW - ROC Curve
KW - Magnetic Resonance Imaging
KW - Electrocardiography
KW - Amylases/blood
KW - Iron/analysis
KW - Iron Overload/blood/etiology
KW - Lipase/blood
KW - Liver/chemistry
KW - Myocardium/chemistry
KW - Pancreas, Exocrine/metabolism
KW - Thalassemia/blood/complications
M3 - SCORING: Journal article
VL - 57
SP - 674
EP - 676
JO - PEDIATR BLOOD CANCER
JF - PEDIATR BLOOD CANCER
SN - 1545-5009
IS - 4
M1 - 4
ER -
