Pallidopenillines: Polyketides from the Alga-Derived Fungus Penicillium thomii Maire KMM 4675
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Pallidopenillines: Polyketides from the Alga-Derived Fungus Penicillium thomii Maire KMM 4675. / Sobolevskaya, Maria P; Leshchenko, Elena V; Hoai, Trinh P T; Denisenko, Vladimir A; Dyshlovoy, Sergey A; Kirichuk, Natalya N; Khudyakova, Yuliya V; Kim, Natalya Yu; Berdyshev, Dmitrii V; Pislyagin, Evgeny A; Kuzmich, Aleksandra S; Gerasimenko, Andrey V; Popov, Roman S; von Amsberg, Gunhild; Antonov, Alexandr S; Afiyatullov, Shamil Sh.
in: J NAT PROD, Jahrgang 79, Nr. 12, 23.12.2016, S. 3031-3038.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Pallidopenillines: Polyketides from the Alga-Derived Fungus Penicillium thomii Maire KMM 4675
AU - Sobolevskaya, Maria P
AU - Leshchenko, Elena V
AU - Hoai, Trinh P T
AU - Denisenko, Vladimir A
AU - Dyshlovoy, Sergey A
AU - Kirichuk, Natalya N
AU - Khudyakova, Yuliya V
AU - Kim, Natalya Yu
AU - Berdyshev, Dmitrii V
AU - Pislyagin, Evgeny A
AU - Kuzmich, Aleksandra S
AU - Gerasimenko, Andrey V
AU - Popov, Roman S
AU - von Amsberg, Gunhild
AU - Antonov, Alexandr S
AU - Afiyatullov, Shamil Sh
PY - 2016/12/23
Y1 - 2016/12/23
N2 - Eleven new polyketides, pallidopenillines 1-11, were isolated from the alga-derived fungus Penicillium thomii. The structures of these compounds were established based on spectroscopic methods. The absolute configuration of pallidopenilline A (1) as 4R, 5S, 8S, 9R, 10R, 13R was established using a combination of the modified Mosher's method, X-ray analysis, and NOESY data. The absolute configurations of 2-5 were determined by time-dependent density functional theory calculations of the ECD spectra and ECD and NOESY data. It was shown that 1-acetylpallidopenilline A (2) and pallidopenilline G (10) inhibit the growth of colonies of 22Rv1 cells by 40% at 2 and 1 μM, respectively.
AB - Eleven new polyketides, pallidopenillines 1-11, were isolated from the alga-derived fungus Penicillium thomii. The structures of these compounds were established based on spectroscopic methods. The absolute configuration of pallidopenilline A (1) as 4R, 5S, 8S, 9R, 10R, 13R was established using a combination of the modified Mosher's method, X-ray analysis, and NOESY data. The absolute configurations of 2-5 were determined by time-dependent density functional theory calculations of the ECD spectra and ECD and NOESY data. It was shown that 1-acetylpallidopenilline A (2) and pallidopenilline G (10) inhibit the growth of colonies of 22Rv1 cells by 40% at 2 and 1 μM, respectively.
U2 - 10.1021/acs.jnatprod.6b00624
DO - 10.1021/acs.jnatprod.6b00624
M3 - SCORING: Journal article
C2 - 28006908
VL - 79
SP - 3031
EP - 3038
JO - J NAT PROD
JF - J NAT PROD
SN - 0163-3864
IS - 12
ER -