PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS
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PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS. / Southey, Melissa C; Goldgar, David E; Winqvist, Robert; Pylkäs, Katri; Couch, Fergus; Tischkowitz, Marc; Foulkes, William D; Dennis, Joe; Michailidou, Kyriaki; van Rensburg, Elizabeth J; Heikkinen, Tuomas; Nevanlinna, Heli; Hopper, John L; Dörk, Thilo; Claes, Kathleen Bm; Reis-Filho, Jorge S; Teo, Zhi Ling; Radice, Paolo; Catucci, Irene; Peterlongo, Paolo; Tsimiklis, Helen; Odefrey, Fabrice A; Dowty, James G; Schmidt, Marjanka K; Broeks, Annegien; Hogervorst, Frans B L; Verhoef, Senno; Carpenter, Jane E; Clarke, Christine L; Scott, Rodney J; Fasching, Peter A; Haeberle, Lothar; Ekici, Arif B; Peto, Julian; Dos-Santos-Silva, Isabel; Fletcher, Olivia; Johnson, Nichola; Bolla, Manjeet K; Sawyer, Elinor J; Tomlinson, Ian; Kerin, Michael J; Miller, Nicola; Marme, Federik; Burwinkel, Barbara; Yang, Rongxi; Guénel, Pascal; Truong, Thérèse; Menegaux, Florence; Sanchez, Marie; Bojesen, Stig E; Nielsen, Sune F; Flyger, Henrik; Benitez, Javier; Zamora, M Pilar; Perez, Jose Ignacio Arias; Menéndez, Primitiva; Anton-Culver, Hoda; Neuhausen, Susan L; Ziogas, Argyrios; Clarke, Christina A; Brenner, Hermann; Arndt, Volker; Stegmaier, Christa; Brauch, Hiltrud; Brüning, Thomas; Ko, Yon-Dschun; Muranen, Taru A; Aittomäki, Kristiina; Blomqvist, Carl; Bogdanova, Natalia V; Antonenkova, Natalia; Lindblom, Annika; Margolin, Sara; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M; Spurdle, Amanda B; Investigators, Kconfab; Wauters, Els; Smeets, Dominiek; Beuselinck, Benoit; Floris, Giuseppe; Chang-Claude, Jenny; Rudolph, Anja; Seibold, Petra; Flesch-Janys, Dieter; Olson, Janet E; Vachon, Celine; Pankratz, Vernon S; McLean, Catriona; Haiman, Christopher A; Henderson, Brian E; Schumacher, Fredrick; Le Marchand, Loic; Kristensen, Vessela; Alnæs, Grethe Grenaker; Zheng, Wei; Hunter, David J; Lindstrom, Sara; Hankinson, Susan E; Kraft, Peter; Andrulis, Irene L; Knight, Julia A; Glendon, Gord; Mulligan, Anna Marie; Jukkola-Vuorinen, Arja; Grip, Mervi; Kauppila, Saila; Devilee, Peter; Tollenaar, Robert A E M; Seynaeve, Caroline; Hollestelle, Antoinette; Garcia-Closas, Montserrat; Figueroa, Jonine; Chanock, Stephen J; Lissowska, Jolanta; Czene, Kamila; Darabi, Hatef; Eriksson, Mikael; Eccles, Diana M; Rafiq, Sajjad; Tapper, William J; Gerty, Sue M; Hooning, Maartje J; Martens, John W M; Collée, J Margriet; Tilanus-Linthorst, Madeleine; Hall, Per; Li, Jingmei; Brand, Judith S; Humphreys, Keith; Cox, Angela; Reed, Malcolm W R; Luccarini, Craig; Baynes, Caroline; Dunning, Alison M; Hamann, Ute; Torres, Diana; Ulmer, Hans Ulrich; Rüdiger, Thomas; Jakubowska, Anna; Lubinski, Jan; Jaworska, Katarzyna; Durda, Katarzyna; Slager, Susan; Toland, Amanda E; Ambrosone, Christine B; Yannoukakos, Drakoulis; Swerdlow, Anthony; Ashworth, Alan; Orr, Nick; Jones, Michael; González-Neira, Anna; Pita, Guillermo; Alonso, M Rosario; Álvarez, Nuria; Herrero, Daniel; Tessier, Daniel C; Vincent, Daniel; Bacot, Francois; Simard, Jacques; Dumont, Martine; Soucy, Penny; Eeles, Rosalind; Muir, Kenneth; Wiklund, Fredrik; Gronberg, Henrik; Schleutker, Johanna; Nordestgaard, Børge G; Weischer, Maren; Travis, Ruth C; Neal, David E; Donovan, Jenny L; Hamdy, Freddie C; Khaw, Kay-Tee; Stanford, Janet L; Blot, William J; Thibodeau, Stephen N; Schaid, Daniel J; Kelley, Joseph L; Maier, Christiane; Kibel, Adam S; Cybulski, Cezary; Cannon-Albright, Lisa A; Butterbach, Katja; Park, Jong-Sung; Kaneva, Radka; Batra, Jyotsna; Teixeira, Manuel R; Kote-Jarai, ZSofia; Olama, Ali Amin Al; Benlloch, Sara; Renner, Stefan P; Hartmann, Arndt; Hein, Alexander; Ruebner, Matthias; Lambrechts, Diether; van Nieuwenhuysen, Els; Vergote, Ignace; Lambretchs, Sandrina; Doherty, Jennifer A; Rossing, Mary Anne; Nickels, Stefan; Eilber, Ursula; Wang-Gohrke, Shan; Odunsi, Kunle; Sucheston-Campbell, Lara E; Friel, Grace; Lurie, Galina; Killeen, Jeffrey L; Wilkens, Lynne R; Goodman, Marc T; Runnebaum, Ingo; Hillemanns, Peter A; Pelttari, Liisa M; Butzow, Ralf; Modugno, Francesmary; Edwards, Robert P; Ness, Roberta B; Moysich, Kirsten B; du Bois, Andreas; Heitz, Florian; Harter, Philipp; Kommoss, Stefan; Karlan, Beth Y; Walsh, Christine; Lester, Jenny; Jensen, Allan; Kjaer, Susanne Krüger; Høgdall, Estrid; Peissel, Bernard; Bonanni, Bernardo; Bernard, Loris; Goode, Ellen L; Fridley, Brooke L; Vierkant, Robert A; Cunningham, Julie M; Larson, Melissa C; Fogarty, Zachary C; Kalli, Kimberly R; Liang, Dong; Lu, Karen H; T Hildebrandt, Michelle A; Wu, Xifeng; Levine, Douglas A; Dao, Fanny; Bisogna, Maria; Berchuck, Andrew; Iversen, Edwin S; Marks, Jeffrey R; Akushevich, Lucy; Cramer, Daniel W; Schildkraut, Joellen M; Terry, Kathryn L; Poole, Elizabeth M; Stampfer, Meir J; Tworoger, Shelley S; Bandera, Elisa V; Orlow, Irene; Olson, Sara H; Bjorge, Line; Salvesen, Helga B; Altena, Anne Mvan; Aben, Katja K H; Kiemeney, Lambertus A; Massuger, Leon F A G; Pejovic, Tanja; Bean, Yukie T; Brooks-Wilson, Angela; Kelemen, Linda E; Cook, Linda S; Le, Nhu D; Górski, Bohdan; Gronwald, Jacek; Menkiszak, Janusz; Høgdall, Claus K; Lundvall, Lene; Nedergaard, Lotte; Engelholm, Svend Aage; Dicks, Ed; Tyrer, Jonathan; Campbell, Ian; McNeish, Iain; Paul, James; Siddiqui, Nadeem; Glasspool, Rosalind; Whittemore, Alice S; Rothstein, Joseph H; McGuire, Valerie; Sieh, Weiva; Cai, Hui; Shu, Xiao-Ou; Teten, Rachel T; Sutphen, Rebecca; McLaughlin, John R; Narod, Steven A; Phelan, Catherine M; Monteiro, Alvaro N A; Fenstermacher, David; Lin, Hui-Yi; Permuth, Jennifer B; Sellers, Thomas A; Chen, Ann Y; Tsai, Ya-Yu; Chen, Zhihua; Gentry-Maharaj, Aleksandra; Gayther, Simon A; Ramus, Susan J; Menon, Usha; Wu, Anna H; Pearce, Celeste L; van den Berg, David; Pike, Malcolm C; Dansonka-Mieszkowska, Agnieszka; Plisiecka-Halasa, Joanna; Moes-Sosnowska, Joanna; Kupryjanczyk, Jolanta; Pharoah, Paul Dp; Song, Honglin; Winship, Ingrid; Chenevix-Trench, Georgia; Giles, Graham; Tavtigian, Sean V; Easton, Doug F; Milne, Roger L; Australian Ovarian Cancer Study.
in: J MED GENET, Jahrgang 53, Nr. 12, 12.2016, S. 800-811.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS
AU - Southey, Melissa C
AU - Goldgar, David E
AU - Winqvist, Robert
AU - Pylkäs, Katri
AU - Couch, Fergus
AU - Tischkowitz, Marc
AU - Foulkes, William D
AU - Dennis, Joe
AU - Michailidou, Kyriaki
AU - van Rensburg, Elizabeth J
AU - Heikkinen, Tuomas
AU - Nevanlinna, Heli
AU - Hopper, John L
AU - Dörk, Thilo
AU - Claes, Kathleen Bm
AU - Reis-Filho, Jorge S
AU - Teo, Zhi Ling
AU - Radice, Paolo
AU - Catucci, Irene
AU - Peterlongo, Paolo
AU - Tsimiklis, Helen
AU - Odefrey, Fabrice A
AU - Dowty, James G
AU - Schmidt, Marjanka K
AU - Broeks, Annegien
AU - Hogervorst, Frans B L
AU - Verhoef, Senno
AU - Carpenter, Jane E
AU - Clarke, Christine L
AU - Scott, Rodney J
AU - Fasching, Peter A
AU - Haeberle, Lothar
AU - Ekici, Arif B
AU - Peto, Julian
AU - Dos-Santos-Silva, Isabel
AU - Fletcher, Olivia
AU - Johnson, Nichola
AU - Bolla, Manjeet K
AU - Sawyer, Elinor J
AU - Tomlinson, Ian
AU - Kerin, Michael J
AU - Miller, Nicola
AU - Marme, Federik
AU - Burwinkel, Barbara
AU - Yang, Rongxi
AU - Guénel, Pascal
AU - Truong, Thérèse
AU - Menegaux, Florence
AU - Sanchez, Marie
AU - Bojesen, Stig E
AU - Nielsen, Sune F
AU - Flyger, Henrik
AU - Benitez, Javier
AU - Zamora, M Pilar
AU - Perez, Jose Ignacio Arias
AU - Menéndez, Primitiva
AU - Anton-Culver, Hoda
AU - Neuhausen, Susan L
AU - Ziogas, Argyrios
AU - Clarke, Christina A
AU - Brenner, Hermann
AU - Arndt, Volker
AU - Stegmaier, Christa
AU - Brauch, Hiltrud
AU - Brüning, Thomas
AU - Ko, Yon-Dschun
AU - Muranen, Taru A
AU - Aittomäki, Kristiina
AU - Blomqvist, Carl
AU - Bogdanova, Natalia V
AU - Antonenkova, Natalia
AU - Lindblom, Annika
AU - Margolin, Sara
AU - Mannermaa, Arto
AU - Kataja, Vesa
AU - Kosma, Veli-Matti
AU - Hartikainen, Jaana M
AU - Spurdle, Amanda B
AU - Investigators, Kconfab
AU - Wauters, Els
AU - Smeets, Dominiek
AU - Beuselinck, Benoit
AU - Floris, Giuseppe
AU - Chang-Claude, Jenny
AU - Rudolph, Anja
AU - Seibold, Petra
AU - Flesch-Janys, Dieter
AU - Olson, Janet E
AU - Vachon, Celine
AU - Pankratz, Vernon S
AU - McLean, Catriona
AU - Haiman, Christopher A
AU - Henderson, Brian E
AU - Schumacher, Fredrick
AU - Le Marchand, Loic
AU - Kristensen, Vessela
AU - Alnæs, Grethe Grenaker
AU - Zheng, Wei
AU - Hunter, David J
AU - Lindstrom, Sara
AU - Hankinson, Susan E
AU - Kraft, Peter
AU - Andrulis, Irene L
AU - Knight, Julia A
AU - Glendon, Gord
AU - Mulligan, Anna Marie
AU - Jukkola-Vuorinen, Arja
AU - Grip, Mervi
AU - Kauppila, Saila
AU - Devilee, Peter
AU - Tollenaar, Robert A E M
AU - Seynaeve, Caroline
AU - Hollestelle, Antoinette
AU - Garcia-Closas, Montserrat
AU - Figueroa, Jonine
AU - Chanock, Stephen J
AU - Lissowska, Jolanta
AU - Czene, Kamila
AU - Darabi, Hatef
AU - Eriksson, Mikael
AU - Eccles, Diana M
AU - Rafiq, Sajjad
AU - Tapper, William J
AU - Gerty, Sue M
AU - Hooning, Maartje J
AU - Martens, John W M
AU - Collée, J Margriet
AU - Tilanus-Linthorst, Madeleine
AU - Hall, Per
AU - Li, Jingmei
AU - Brand, Judith S
AU - Humphreys, Keith
AU - Cox, Angela
AU - Reed, Malcolm W R
AU - Luccarini, Craig
AU - Baynes, Caroline
AU - Dunning, Alison M
AU - Hamann, Ute
AU - Torres, Diana
AU - Ulmer, Hans Ulrich
AU - Rüdiger, Thomas
AU - Jakubowska, Anna
AU - Lubinski, Jan
AU - Jaworska, Katarzyna
AU - Durda, Katarzyna
AU - Slager, Susan
AU - Toland, Amanda E
AU - Ambrosone, Christine B
AU - Yannoukakos, Drakoulis
AU - Swerdlow, Anthony
AU - Ashworth, Alan
AU - Orr, Nick
AU - Jones, Michael
AU - González-Neira, Anna
AU - Pita, Guillermo
AU - Alonso, M Rosario
AU - Álvarez, Nuria
AU - Herrero, Daniel
AU - Tessier, Daniel C
AU - Vincent, Daniel
AU - Bacot, Francois
AU - Simard, Jacques
AU - Dumont, Martine
AU - Soucy, Penny
AU - Eeles, Rosalind
AU - Muir, Kenneth
AU - Wiklund, Fredrik
AU - Gronberg, Henrik
AU - Schleutker, Johanna
AU - Nordestgaard, Børge G
AU - Weischer, Maren
AU - Travis, Ruth C
AU - Neal, David E
AU - Donovan, Jenny L
AU - Hamdy, Freddie C
AU - Khaw, Kay-Tee
AU - Stanford, Janet L
AU - Blot, William J
AU - Thibodeau, Stephen N
AU - Schaid, Daniel J
AU - Kelley, Joseph L
AU - Maier, Christiane
AU - Kibel, Adam S
AU - Cybulski, Cezary
AU - Cannon-Albright, Lisa A
AU - Butterbach, Katja
AU - Park, Jong-Sung
AU - Kaneva, Radka
AU - Batra, Jyotsna
AU - Teixeira, Manuel R
AU - Kote-Jarai, ZSofia
AU - Olama, Ali Amin Al
AU - Benlloch, Sara
AU - Renner, Stefan P
AU - Hartmann, Arndt
AU - Hein, Alexander
AU - Ruebner, Matthias
AU - Lambrechts, Diether
AU - van Nieuwenhuysen, Els
AU - Vergote, Ignace
AU - Lambretchs, Sandrina
AU - Doherty, Jennifer A
AU - Rossing, Mary Anne
AU - Nickels, Stefan
AU - Eilber, Ursula
AU - Wang-Gohrke, Shan
AU - Odunsi, Kunle
AU - Sucheston-Campbell, Lara E
AU - Friel, Grace
AU - Lurie, Galina
AU - Killeen, Jeffrey L
AU - Wilkens, Lynne R
AU - Goodman, Marc T
AU - Runnebaum, Ingo
AU - Hillemanns, Peter A
AU - Pelttari, Liisa M
AU - Butzow, Ralf
AU - Modugno, Francesmary
AU - Edwards, Robert P
AU - Ness, Roberta B
AU - Moysich, Kirsten B
AU - du Bois, Andreas
AU - Heitz, Florian
AU - Harter, Philipp
AU - Kommoss, Stefan
AU - Karlan, Beth Y
AU - Walsh, Christine
AU - Lester, Jenny
AU - Jensen, Allan
AU - Kjaer, Susanne Krüger
AU - Høgdall, Estrid
AU - Peissel, Bernard
AU - Bonanni, Bernardo
AU - Bernard, Loris
AU - Goode, Ellen L
AU - Fridley, Brooke L
AU - Vierkant, Robert A
AU - Cunningham, Julie M
AU - Larson, Melissa C
AU - Fogarty, Zachary C
AU - Kalli, Kimberly R
AU - Liang, Dong
AU - Lu, Karen H
AU - T Hildebrandt, Michelle A
AU - Wu, Xifeng
AU - Levine, Douglas A
AU - Dao, Fanny
AU - Bisogna, Maria
AU - Berchuck, Andrew
AU - Iversen, Edwin S
AU - Marks, Jeffrey R
AU - Akushevich, Lucy
AU - Cramer, Daniel W
AU - Schildkraut, Joellen M
AU - Terry, Kathryn L
AU - Poole, Elizabeth M
AU - Stampfer, Meir J
AU - Tworoger, Shelley S
AU - Bandera, Elisa V
AU - Orlow, Irene
AU - Olson, Sara H
AU - Bjorge, Line
AU - Salvesen, Helga B
AU - Altena, Anne Mvan
AU - Aben, Katja K H
AU - Kiemeney, Lambertus A
AU - Massuger, Leon F A G
AU - Pejovic, Tanja
AU - Bean, Yukie T
AU - Brooks-Wilson, Angela
AU - Kelemen, Linda E
AU - Cook, Linda S
AU - Le, Nhu D
AU - Górski, Bohdan
AU - Gronwald, Jacek
AU - Menkiszak, Janusz
AU - Høgdall, Claus K
AU - Lundvall, Lene
AU - Nedergaard, Lotte
AU - Engelholm, Svend Aage
AU - Dicks, Ed
AU - Tyrer, Jonathan
AU - Campbell, Ian
AU - McNeish, Iain
AU - Paul, James
AU - Siddiqui, Nadeem
AU - Glasspool, Rosalind
AU - Whittemore, Alice S
AU - Rothstein, Joseph H
AU - McGuire, Valerie
AU - Sieh, Weiva
AU - Cai, Hui
AU - Shu, Xiao-Ou
AU - Teten, Rachel T
AU - Sutphen, Rebecca
AU - McLaughlin, John R
AU - Narod, Steven A
AU - Phelan, Catherine M
AU - Monteiro, Alvaro N A
AU - Fenstermacher, David
AU - Lin, Hui-Yi
AU - Permuth, Jennifer B
AU - Sellers, Thomas A
AU - Chen, Ann Y
AU - Tsai, Ya-Yu
AU - Chen, Zhihua
AU - Gentry-Maharaj, Aleksandra
AU - Gayther, Simon A
AU - Ramus, Susan J
AU - Menon, Usha
AU - Wu, Anna H
AU - Pearce, Celeste L
AU - van den Berg, David
AU - Pike, Malcolm C
AU - Dansonka-Mieszkowska, Agnieszka
AU - Plisiecka-Halasa, Joanna
AU - Moes-Sosnowska, Joanna
AU - Kupryjanczyk, Jolanta
AU - Pharoah, Paul Dp
AU - Song, Honglin
AU - Winship, Ingrid
AU - Chenevix-Trench, Georgia
AU - Giles, Graham
AU - Tavtigian, Sean V
AU - Easton, Doug F
AU - Milne, Roger L
AU - Australian Ovarian Cancer Study
N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.
PY - 2016/12
Y1 - 2016/12
N2 - BACKGROUND: The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some of these mutations are associated with breast cancer risk as high as those associated with rare BRCA2 mutations. We aimed to estimate the relative risks associated with specific rare variants in PALB2, CHEK2 and ATM via a multicentre case-control study.METHODS: We genotyped 10 rare mutations using the custom iCOGS array: PALB2 c.1592delT, c.2816T>G and c.3113G>A, CHEK2 c.349A>G, c.538C>T, c.715G>A, c.1036C>T, c.1312G>T, and c.1343T>G and ATM c.7271T>G. We assessed associations with breast cancer risk (42 671 cases and 42 164 controls), as well as prostate (22 301 cases and 22 320 controls) and ovarian (14 542 cases and 23 491 controls) cancer risk, for each variant.RESULTS: For European women, strong evidence of association with breast cancer risk was observed for PALB2 c.1592delT OR 3.44 (95% CI 1.39 to 8.52, p=7.1×10(-5)), PALB2 c.3113G>A OR 4.21 (95% CI 1.84 to 9.60, p=6.9×10(-8)) and ATM c.7271T>G OR 11.0 (95% CI 1.42 to 85.7, p=0.0012). We also found evidence of association with breast cancer risk for three variants in CHEK2, c.349A>G OR 2.26 (95% CI 1.29 to 3.95), c.1036C>T OR 5.06 (95% CI 1.09 to 23.5) and c.538C>T OR 1.33 (95% CI 1.05 to 1.67) (p≤0.017). Evidence for prostate cancer risk was observed for CHEK2 c.1343T>G OR 3.03 (95% CI 1.53 to 6.03, p=0.0006) for African men and CHEK2 c.1312G>T OR 2.21 (95% CI 1.06 to 4.63, p=0.030) for European men. No evidence of association with ovarian cancer was found for any of these variants.CONCLUSIONS: This report adds to accumulating evidence that at least some variants in these genes are associated with an increased risk of breast cancer that is clinically important.
AB - BACKGROUND: The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some of these mutations are associated with breast cancer risk as high as those associated with rare BRCA2 mutations. We aimed to estimate the relative risks associated with specific rare variants in PALB2, CHEK2 and ATM via a multicentre case-control study.METHODS: We genotyped 10 rare mutations using the custom iCOGS array: PALB2 c.1592delT, c.2816T>G and c.3113G>A, CHEK2 c.349A>G, c.538C>T, c.715G>A, c.1036C>T, c.1312G>T, and c.1343T>G and ATM c.7271T>G. We assessed associations with breast cancer risk (42 671 cases and 42 164 controls), as well as prostate (22 301 cases and 22 320 controls) and ovarian (14 542 cases and 23 491 controls) cancer risk, for each variant.RESULTS: For European women, strong evidence of association with breast cancer risk was observed for PALB2 c.1592delT OR 3.44 (95% CI 1.39 to 8.52, p=7.1×10(-5)), PALB2 c.3113G>A OR 4.21 (95% CI 1.84 to 9.60, p=6.9×10(-8)) and ATM c.7271T>G OR 11.0 (95% CI 1.42 to 85.7, p=0.0012). We also found evidence of association with breast cancer risk for three variants in CHEK2, c.349A>G OR 2.26 (95% CI 1.29 to 3.95), c.1036C>T OR 5.06 (95% CI 1.09 to 23.5) and c.538C>T OR 1.33 (95% CI 1.05 to 1.67) (p≤0.017). Evidence for prostate cancer risk was observed for CHEK2 c.1343T>G OR 3.03 (95% CI 1.53 to 6.03, p=0.0006) for African men and CHEK2 c.1312G>T OR 2.21 (95% CI 1.06 to 4.63, p=0.030) for European men. No evidence of association with ovarian cancer was found for any of these variants.CONCLUSIONS: This report adds to accumulating evidence that at least some variants in these genes are associated with an increased risk of breast cancer that is clinically important.
KW - Journal Article
U2 - 10.1136/jmedgenet-2016-103839
DO - 10.1136/jmedgenet-2016-103839
M3 - SCORING: Journal article
C2 - 27595995
VL - 53
SP - 800
EP - 811
JO - J MED GENET
JF - J MED GENET
SN - 0022-2593
IS - 12
ER -