Pain in survivors of Ewing sarcoma: Prevalence, associated factors and prediction of recurrence

Melina Heinemann; Christiane Hoffmann; Jendrik Hardes; Wiebke Guder; Arne Streitbürger; Miriam Götte; Theresa Luisa Welz; Heribert Jürgens; Andreas Ranft; Volker Vieth; Matthias Weckesser; Michael Schäfers; Lars Stegger; Uta Dirksen

doi:10.1002/pbc.28801

Pain in survivors of Ewing sarcoma: Prevalence, associated factors and prediction of recurrence

Standard

Pain in survivors of Ewing sarcoma: Prevalence, associated factors and prediction of recurrence. / Heinemann, Melina; Hoffmann, Christiane; Hardes, Jendrik; Guder, Wiebke; Streitbürger, Arne; Götte, Miriam; Welz, Theresa Luisa; Jürgens, Heribert; Ranft, Andreas; Vieth, Volker; Weckesser, Matthias; Schäfers, Michael; Stegger, Lars; Dirksen, Uta.

in: PEDIATR BLOOD CANCER, Jahrgang 68, Nr. 3, e28801, 03.2021.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Heinemann, M, Hoffmann, C, Hardes, J, Guder, W, Streitbürger, A, Götte, M, Welz, TL, Jürgens, H, Ranft, A, Vieth, V, Weckesser, M, Schäfers, M, Stegger, L & Dirksen, U 2021, 'Pain in survivors of Ewing sarcoma: Prevalence, associated factors and prediction of recurrence', PEDIATR BLOOD CANCER, Jg. 68, Nr. 3, e28801. https://doi.org/10.1002/pbc.28801

APA

Heinemann, M., Hoffmann, C., Hardes, J., Guder, W., Streitbürger, A., Götte, M., Welz, T. L., Jürgens, H., Ranft, A., Vieth, V., Weckesser, M., Schäfers, M., Stegger, L., & Dirksen, U. (2021). Pain in survivors of Ewing sarcoma: Prevalence, associated factors and prediction of recurrence. PEDIATR BLOOD CANCER, 68(3), [e28801]. https://doi.org/10.1002/pbc.28801

Vancouver

Heinemann M, Hoffmann C, Hardes J, Guder W, Streitbürger A, Götte M et al. Pain in survivors of Ewing sarcoma: Prevalence, associated factors and prediction of recurrence. PEDIATR BLOOD CANCER. 2021 Mär;68(3). e28801. https://doi.org/10.1002/pbc.28801

Bibtex

@article{bcd7f5760ee5406aaa77cfef0027db74,

title = "Pain in survivors of Ewing sarcoma: Prevalence, associated factors and prediction of recurrence",

abstract = "BACKGROUND: While the prognosis of patients with Ewing sarcoma (EwS) is improving, little is known about the frequency of pain and its risk factors in survivors of EwS. This study aims to analyse the prevalence and risk factors of pain and its predictive value for recurrence.PATIENTS AND METHODS: In patients with remission after treatment of EwS, frequency and characteristics of pain within the first 5 years of follow up were assessed retrospectively.RESULTS: Of 80 patients, 37 (46%) presented with at least one episode of pain. Chronic pain (>3 months) was observed in 10 patients (13%). Experience of at least one episode of pain was associated with prior combined local treatment (surgery and radiation compared to surgery alone; odds ratio [OR] 5.83, 95% confidence interval [CI] 1.43-34.9, P = .007). A total of 59 episodes of pain were observed, including 47 acute and 12 chronic episodes. Lower limb pain accounted for 46% (27/59) of all episodes of pain, and was associated with primary tumour of the pelvis or lower extremity (OR 4.29, 95% CI 1.18-18.21, P = .025), which represented 64% (51/80) of all EwS. The positive predictive value of pain for recurrence was only 12%.CONCLUSION: Pain is a common problem in survivors of EwS, which mostly affects the lower extremity, and should be regularly assessed. Interventions to reduce pain may be particularly important in patients with combined local treatment with surgery and radiation, who seem to be at considerably increased risk for pain. Patients presenting with pain should be examined for recurrence.",

author = "Melina Heinemann and Christiane Hoffmann and Jendrik Hardes and Wiebke Guder and Arne Streitb{\"u}rger and Miriam G{\"o}tte and Welz, {Theresa Luisa} and Heribert J{\"u}rgens and Andreas Ranft and Volker Vieth and Matthias Weckesser and Michael Sch{\"a}fers and Lars Stegger and Uta Dirksen",

note = "{\textcopyright} 2020 Wiley Periodicals LLC.",

year = "2021",

month = mar,

doi = "10.1002/pbc.28801",

language = "English",

volume = "68",

journal = "PEDIATR BLOOD CANCER",

issn = "1545-5009",

publisher = "Wiley-Liss Inc.",

number = "3",

}

RIS

TY - JOUR

T1 - Pain in survivors of Ewing sarcoma: Prevalence, associated factors and prediction of recurrence

AU - Heinemann, Melina

AU - Hoffmann, Christiane

AU - Hardes, Jendrik

AU - Guder, Wiebke

AU - Streitbürger, Arne

AU - Götte, Miriam

AU - Welz, Theresa Luisa

AU - Jürgens, Heribert

AU - Ranft, Andreas

AU - Vieth, Volker

AU - Weckesser, Matthias

AU - Schäfers, Michael

AU - Stegger, Lars

AU - Dirksen, Uta

PY - 2021/3

Y1 - 2021/3

N2 - BACKGROUND: While the prognosis of patients with Ewing sarcoma (EwS) is improving, little is known about the frequency of pain and its risk factors in survivors of EwS. This study aims to analyse the prevalence and risk factors of pain and its predictive value for recurrence.PATIENTS AND METHODS: In patients with remission after treatment of EwS, frequency and characteristics of pain within the first 5 years of follow up were assessed retrospectively.RESULTS: Of 80 patients, 37 (46%) presented with at least one episode of pain. Chronic pain (>3 months) was observed in 10 patients (13%). Experience of at least one episode of pain was associated with prior combined local treatment (surgery and radiation compared to surgery alone; odds ratio [OR] 5.83, 95% confidence interval [CI] 1.43-34.9, P = .007). A total of 59 episodes of pain were observed, including 47 acute and 12 chronic episodes. Lower limb pain accounted for 46% (27/59) of all episodes of pain, and was associated with primary tumour of the pelvis or lower extremity (OR 4.29, 95% CI 1.18-18.21, P = .025), which represented 64% (51/80) of all EwS. The positive predictive value of pain for recurrence was only 12%.CONCLUSION: Pain is a common problem in survivors of EwS, which mostly affects the lower extremity, and should be regularly assessed. Interventions to reduce pain may be particularly important in patients with combined local treatment with surgery and radiation, who seem to be at considerably increased risk for pain. Patients presenting with pain should be examined for recurrence.

AB - BACKGROUND: While the prognosis of patients with Ewing sarcoma (EwS) is improving, little is known about the frequency of pain and its risk factors in survivors of EwS. This study aims to analyse the prevalence and risk factors of pain and its predictive value for recurrence.PATIENTS AND METHODS: In patients with remission after treatment of EwS, frequency and characteristics of pain within the first 5 years of follow up were assessed retrospectively.RESULTS: Of 80 patients, 37 (46%) presented with at least one episode of pain. Chronic pain (>3 months) was observed in 10 patients (13%). Experience of at least one episode of pain was associated with prior combined local treatment (surgery and radiation compared to surgery alone; odds ratio [OR] 5.83, 95% confidence interval [CI] 1.43-34.9, P = .007). A total of 59 episodes of pain were observed, including 47 acute and 12 chronic episodes. Lower limb pain accounted for 46% (27/59) of all episodes of pain, and was associated with primary tumour of the pelvis or lower extremity (OR 4.29, 95% CI 1.18-18.21, P = .025), which represented 64% (51/80) of all EwS. The positive predictive value of pain for recurrence was only 12%.CONCLUSION: Pain is a common problem in survivors of EwS, which mostly affects the lower extremity, and should be regularly assessed. Interventions to reduce pain may be particularly important in patients with combined local treatment with surgery and radiation, who seem to be at considerably increased risk for pain. Patients presenting with pain should be examined for recurrence.

U2 - 10.1002/pbc.28801

DO - 10.1002/pbc.28801

M3 - SCORING: Journal article

C2 - 33179838

VL - 68

JO - PEDIATR BLOOD CANCER

JF - PEDIATR BLOOD CANCER

SN - 1545-5009

IS - 3

M1 - e28801

ER -