[Pain contra pain : the concept of DNIC].
Standard
[Pain contra pain : the concept of DNIC]. / Sprenger, Christian; May, Arne; Büchel, Christian.
in: SCHMERZ, Jahrgang 24, Nr. 6, 6, 2010, S. 569-574.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - [Pain contra pain : the concept of DNIC].
AU - Sprenger, Christian
AU - May, Arne
AU - Büchel, Christian
PY - 2010
Y1 - 2010
N2 - Diffuse noxious inhibitory controls (DNIC) refer to the observation that the activity of multi-receptive neurons of the spinal cord and trigeminal system can be strongly suppressed by an intensive pain stimulus outside their peripheral receptive field. This effect represents a neurophysiologically well-established animal model of endogenous pain modulation that has been consistently demonstrated across different species. Electrophysiological and anatomical data support the view that DNIC are sustained by a largely independent spino-bulbo-spinal loop that critically involves the caudal medulla. It is assumed that, corresponding to the animal model, the perceptive effects of 'heterotopic noxious conditioning stimulations' (HNCS) in humans are predominantly based on the DNIC mechanism. This review focusses on DNIC and HNCS including similarities, divergences and their potential clinical relevance.
AB - Diffuse noxious inhibitory controls (DNIC) refer to the observation that the activity of multi-receptive neurons of the spinal cord and trigeminal system can be strongly suppressed by an intensive pain stimulus outside their peripheral receptive field. This effect represents a neurophysiologically well-established animal model of endogenous pain modulation that has been consistently demonstrated across different species. Electrophysiological and anatomical data support the view that DNIC are sustained by a largely independent spino-bulbo-spinal loop that critically involves the caudal medulla. It is assumed that, corresponding to the animal model, the perceptive effects of 'heterotopic noxious conditioning stimulations' (HNCS) in humans are predominantly based on the DNIC mechanism. This review focusses on DNIC and HNCS including similarities, divergences and their potential clinical relevance.
M3 - SCORING: Zeitschriftenaufsatz
VL - 24
SP - 569
EP - 574
JO - SCHMERZ
JF - SCHMERZ
SN - 0932-433X
IS - 6
M1 - 6
ER -
