p53 Predictive Value for pT1-2 N0 Disease at Radical Cystectomy.
Standard
p53 Predictive Value for pT1-2 N0 Disease at Radical Cystectomy. / Shariat, Shahrokh F; Lotan, Yair; Karakiewicz, Pierre I; Ashfaq, Raheela; Isbarn, Hendrik; Fradet, Yves; Bastian, Patrick J; Nielsen, Matthew E; Capitanio, Umberto; Jeldres, Claudio; Montorsi, Francesco; Müller, Stefan C; Karam, Jose A; Heukamp, Lukas C; Netto, George; Lerner, Seth P; Sagalowsky, Arthur I; Cote, Richard J.
in: J UROLOGY, 2009.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - p53 Predictive Value for pT1-2 N0 Disease at Radical Cystectomy.
AU - Shariat, Shahrokh F
AU - Lotan, Yair
AU - Karakiewicz, Pierre I
AU - Ashfaq, Raheela
AU - Isbarn, Hendrik
AU - Fradet, Yves
AU - Bastian, Patrick J
AU - Nielsen, Matthew E
AU - Capitanio, Umberto
AU - Jeldres, Claudio
AU - Montorsi, Francesco
AU - Müller, Stefan C
AU - Karam, Jose A
AU - Heukamp, Lukas C
AU - Netto, George
AU - Lerner, Seth P
AU - Sagalowsky, Arthur I
AU - Cote, Richard J
PY - 2009
Y1 - 2009
N2 - PURPOSE: Approximately 15% to 30% of patients with pT1-2N0M0 urothelial carcinoma of the bladder experience disease progression despite radical cystectomy with curative intent. We determined whether p53 expression would improve the prediction of disease progression after radical cystectomy for pT1-2N0M0 UCB. MATERIALS AND METHODS: In a multi-institutional retrospective cohort we identified 324 patients with pT1-2N0M0 urothelial carcinoma of the bladder who underwent radical cystectomy. Analysis focused on a testing cohort of 272 patients and an external validation of 52. Competing risks regression models were used to test the association of variables with cancer specific mortality after accounting for nonbladder cancer caused mortality. RESULTS: In the testing cohort 91 patients (33.5%) had altered p53 expression (p53alt). On multivariate competing risks regression analysis altered p53 achieved independent status for predicting disease recurrence and cancer specific mortality (each p
AB - PURPOSE: Approximately 15% to 30% of patients with pT1-2N0M0 urothelial carcinoma of the bladder experience disease progression despite radical cystectomy with curative intent. We determined whether p53 expression would improve the prediction of disease progression after radical cystectomy for pT1-2N0M0 UCB. MATERIALS AND METHODS: In a multi-institutional retrospective cohort we identified 324 patients with pT1-2N0M0 urothelial carcinoma of the bladder who underwent radical cystectomy. Analysis focused on a testing cohort of 272 patients and an external validation of 52. Competing risks regression models were used to test the association of variables with cancer specific mortality after accounting for nonbladder cancer caused mortality. RESULTS: In the testing cohort 91 patients (33.5%) had altered p53 expression (p53alt). On multivariate competing risks regression analysis altered p53 achieved independent status for predicting disease recurrence and cancer specific mortality (each p
M3 - SCORING: Zeitschriftenaufsatz
JO - J UROLOGY
JF - J UROLOGY
SN - 0022-5347
ER -