P-112 Virtual reality induced gait manipulation affects cortico- subthalamic networks in parkinsonian patients
Beteiligte Einrichtungen
Abstract
Methods: PD patients with chronically implanted subthalamic deep brain stimulation (STN DBS) systems with ‘‘sensing” neurostimula- tors (PerceptTM, Medtronic) performed a stepping task in a supine position on a custom-made stepping device in a first-person view VR presented via head-mounted display (Vive, HTC). The VR was exploited to modulate the step length by individually spaced mark- ers on the floor. Markers appeared either symmetrically or shortened to 65% for one leg to induce asymmetric stepping pattern. Simultaneous recordings of 24-channel EEG (Smarting, mBrainTrain), bilateral subthalamic LFPs, movement sensors attached to both legs (CMS20, Zebris) and pupillometry (VR binocu- lar Add-on, Pupil labs), were performed to capture multi-site net- work activity changes.
Clinical assessment consists of gait parameters measured using GAITRite! electronic walkway system, MDS_UPDRS III and Zieglers test performed in medication (Med) OFF/STN DBS (Stim) OFF, Med OFF/Stim ON and Med ON/Stim ON. Furthermore, questionnaires (MDS UPDRS I, II, IV, FOG-Q, FOG-C) and a cognitive test (MoCA) are conducted.
Oscillatory properties of LFPs, EEG and pupillometry are assessed referring to gait events.
In this ongoing trial, 7 PD patients (6 male, 1 female, age 64.4±6.2, disease duration 14.1±8.8 yrs.) were assessed 2.7±4.5 years after STN DBS implantation.
Results: MDS UPDRS improved in STIM ON MED ON (21.6±15.4) by 46% and STIM ON MED OFF (31±13.3) by 24.2% compared to STIM OFF MED OFF (40±14.6). Preliminary findings indicate a decrease in beta power between stepping and resting condition and a slight increase during stepping irregularities.
Conclusions: Simultaneous recording of synchronized LFPs, EEG, pupillometry and accelerometry is feasible in this experimental set- ting and the VR induced gait modulation seems to have an impact on beta-band gait network activities.
Bibliografische Daten
Originalsprache | Englisch |
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Aufsatznummer | P-112 |
ISSN | 1388-2457 |
DOIs | |
Status | Veröffentlicht - 04.2023 |
Veranstaltung | Kongress für Klinische Neurowissenschaften mit Fortbildungsakademie: Analyse, Modelle, Modulation - UKE Hamburg, Hamburg, Deutschland Dauer: 02.03.2023 → 04.03.2023 Konferenznummer: 23 https://www.kongress-dgkn.de/ |